Reteplase (r PA)

What is Reteplase r PA

Reteplase is an intravenous recombinant plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of death and heart failure.

Brand Name

  • Retavase
  • Retavase Half-Kit

Indications & Dosage

  • acute myocardial infarction, STEMI
  • arterial thromboembolism
  • occluded arteriovenous (AV) cannula
  • occluded IV catheter

For the treatment of acute myocardial infarction, STEMI to reduce the risk of death and heart failure

Side Effects

  1. anaphylactoid reactions
  2. anemia
  3. bleeding
  4. cholesterol microembolization
  5. dyspnea
  6. edema
  7. erythema
  8. GI bleeding
  9. hypertension
  10. hypotension
  11. intracranial bleeding
  12. livedo reticularis
  13. myocardial infarction
  14. pancreatitis
  15. pruritus
  16. purple-toe syndrome
  17. rash
  18. renal failure (unspecified)
  19. rhabdomyolysis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • aneurysm
  • arteriovenous malformation
  • bleeding
  • brain tumor
  • breast-feeding
  • coagulopathy
  • head trauma
  • hypertension
  • intracranial mass
  • intramuscular injections
  • labor
  • laboratory test interference
  • obstetric delivery
  • pregnancy
  • stroke
  • surgery
  • venipuncture

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Alpha interferons
  • Altretamine
  • Aminocaproic Acid
  • Aminosalicylate sodium, Aminosalicylic acid
  • Anagrelide
  • Antimetabolites
  • Antithrombin III
  • Antithymocyte Globulin
  • Apixaban
  • Aprotinin
  • Argatroban
  • Arsenic Trioxide
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betrixaban
  • Bexarotene
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bivalirudin
  • Chlorambucil
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Clofarabine
  • Clopidogrel
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Danazol
  • Defibrotide
  • Denileukin Diftitox
  • Desirudin
  • Desvenlafaxine
  • Dipyridamole
  • Drotrecogin Alfa
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Estramustine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Folate analogs
  • Fondaparinux
  • Garlic, Allium sativum
  • Ginger, Zingiber officinale
  • Ginkgo, Ginkgo biloba
  • Green Tea
  • Heparin
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Icosapent ethyl
  • Intravenous Lipid Emulsions
  • Lepirudin
  • Levomilnacipran
  • Lomustine, CCNU
  • Magnesium Salicylate
  • Methoxsalen
  • Methylsulfonylmethane, MSM
  • Milnacipran
  • Nonsteroidal antiinflammatory drugs
  • Pegaspargase
  • Pentosan
  • Photosensitizing agents (topical)
  • Platelet Inhibitors
  • Prasugrel
  • Rivaroxaban
  • Salicylates
  • Salsalate
  • Selective serotonin reuptake inhibitors
  • Sodium Hyaluronate, Hyaluronic Acid
  • Sulfinpyrazone
  • Thrombin Inhibitors
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tranexamic Acid
  • Trazodone
  • Tretinoin, ATRA
  • Venlafaxine
  • Verteporfin
  • Vilazodone
  • Vorapaxar
  • Vorinostat
  • Vortioxetine
  • Warfarin
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