Sodium Hyaluronate and Hyaluronic Acid

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What is Sodium Hyaluronate and Hyaluronic Acid

Sodium hyaluronate is the high molecular weight fractions of purified natural sodium hyaluronic acid.

It is used clinically as an intra-articular, intradermal, and ophthalmic viscoelastic agent and applied topically to protect against abrasion, friction, and desiccation

Indications & Dosage

  • atopic dermatitis
  • burns
  • contact dermatitis
  • decubitus ulcer
  • dermatitis
  • diabetic foot ulcer
  • facial wrinkles
  • ocular surgery
  • ophthalmic surgery
  • osteoarthritis
  • skin abrasion
  • wound management

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. anxiety
  5. arrhythmia exacerbation
  6. arthralgia
  7. arthropathy
  8. asthenia
  9. back pain
  10. chills
  11. corneal edema
  12. corneal opacification
  13. cystitis
  14. depression
  15. diarrhea
  16. dizziness
  17. dysgeusia
  18. dyspepsia
  19. ecchymosis
  20. edema
  21. erythema
  22. fatigue
  23. fever
  24. headache
  25. infection
  26. influenza
  27. injection site reaction
  28. iritis
  29. leukocytosis
  30. metallic taste
  31. muscle cramps
  32. musculoskeletal pain
  33. myalgia
  34. nausea
  35. ocular hypertension
  36. ocular infection
  37. ocular pain
  38. paresthesias
  39. peptic ulcer
  40. peripheral edema
  41. pharyngitis
  42. phlebitis
  43. pruritus
  44. purpura
  45. rash
  46. rhinitis
  47. sinusitis
  48. synovitis
  49. thrombocytopenia
  50. urticaria
  51. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticoagulant therapy
  • aphakia
  • breast-feeding
  • children
  • coagulopathy
  • diabetes mellitus
  • egg hypersensitivity
  • glaucoma
  • hemophilia
  • infants
  • infection
  • intraarterial administration
  • intravenous administration
  • neonates
  • pregnancy
  • skin disease
  • thrombocytopenia

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Alteplase
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Celecoxib
  • Anagrelide
  • Antithrombin III
  • Ardeparin
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Celecoxib
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Clopidogrel
  • Cranberry, Vaccinium macrocarpon Ait.
  • Dalteparin
  • Danaparoid
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Enoxaparin
  • Eptifibatide
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Flurbiprofen
  • Fondaparinux
  • Heparin
  • Hydrocodone; Ibuprofen
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Low Molecular Weight Heparins
  • Magnesium Salicylate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nonsteroidal antiinflammatory drugs
  • Oxaprozin
  • Pentosan
  • Piroxicam
  • Platelet Inhibitors
  • Prasugrel
  • Reteplase, r-PA
  • Rofecoxib
  • Salicylates
  • Salsalate
  • St. John’s Wort, Hypericum perforatum
  • Streptokinase
  • Sulindac
  • Tenecteplase
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolmetin
  • Urokinase
  • Valdecoxib
  • Vitamin E
  • Vitamin E
  • Vorapaxar
  • Warfarin

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