Ursodeoxycholic Acid and Ursodiol

What is Ursodeoxycholic Acid and Ursodiol

Ursodeoxycholic acid, ursodiol is an oral, naturally occurring bile acid agent. Ursodiol is FDA-approved to solubilize radiolucent (cholesterol) gallstones, prevent gallstone formation in obese patients experiencing rapid weight loss, and for the treatment of patients with primary biliary cirrhosis.

Brand Name

  • Actigall
  • Urso 250
  • Urso Forte

Indications

  • biliary cirrhosis
  • cholangitis
  • cholelithiasis
  • cholestasis
  • gallstone prophylaxis
  • intrahepatic cholestasis of pregnancy (ICP)
  • non-alcoholic steatosis-hepatitis (NASH)

Side Effects

  • abdominal pain
  • alopecia
  • anaphylactoid reactions
  • angioedema
  • anorexia
  • arthralgia
  • asthenia
  • chest pain (unspecified)
  • constipation
  • cough
  • diabetes mellitus
  • diarrhea
  • dizziness
  • dysmenorrhea
  • dyspepsia
  • elevated hepatic enzymes
  • esophagitis
  • fever
  • flatulence
  • headache
  • hyperbilirubinemia
  • hyperglycemia
  • hypertension
  • infection
  • jaundice
  • laryngeal edema
  • leukopenia
  • malaise
  • musculoskeletal pain
  • myalgia
  • nausea
  • peptic ulcer
  • peripheral edema
  • pharyngitis
  • pruritus
  • rash
  • rhinitis
  • thrombocytopenia
  • urticaria
  • vomiting

Monitoring Parameters

Monitoring Parameters

  • cholecystogram
  • gallbladder ultrasound
  • LFTs

Contraindications

  • ascites
  • bile acid agents hypersensitivity
  • biliary obstruction
  • biliary tract disease
  • biliary-GI fistula
  • bleeding
  • breast-feeding
  • cholangitis
  • encephalopathy
  • esophageal varices
  • geriatric
  • jaundice
  • pancreatitis
  • pregnancy

Interactions

  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Charcoal
  • Cholestyramine
  • Ciprofloxacin
  • Colesevelam
  • Colestipol
  • Estrogens
  • Fenofibrate
  • Fenofibric Acid
  • Fibric acid derivatives
  • Gemfibrozil
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