Revefenacin

What is Revefenacin

Revefenacin is a respiratory antimuscarinic that acts as a bronchodilator.

It is used for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

Brand Name

YUPELRI

Indications

  • chronic bronchitis
  • chronic obstructive pulmonary disease (COPD)
  • emphysema

For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. back pain
  4. blurred vision
  5. bronchospasm
  6. cough
  7. cycloplegia
  8. dizziness
  9. dysuria
  10. headache
  11. hypertension
  12. infection
  13. mydriasis
  14. ocular hypertension
  15. pharyngitis
  16. pruritus
  17. urinary retention
  18. urticaria

Monitoring Parameters

  • pulmonary function tests (PFTs)

Contraindications

  • acute bronchospasm
  • anticholinergic medications
  • breast-feeding
  • cardiac disease
  • children
  • closed-angle glaucoma
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • infants
  • ocular exposure
  • paradoxical bronchospasm
  • pregnancy
  • prostatic hypertrophy
  • urinary retention
  • urinary tract obstruction

Interactions

  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anticholinergics
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Chlordiazepoxide; Clidinium
  • Clarithromycin
  • Cobicistat
  • Cyclosporine
  • Daclatasvir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dicyclomine
  • Elexacaftor; tezacaftor; ivacaftor
  • Eltrombopag
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Flavoxate
  • Gemfibrozil
  • Glecaprevir; Pibrentasvir
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Homatropine; Hydrocodone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indacaterol; Glycopyrrolate
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Leflunomide
  • Letermovir
  • Lopinavir; Ritonavir
  • Mepenzolate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Obeticholic Acid
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oxybutynin
  • Propantheline
  • Rifampin
  • Scopolamine
  • Simeprevir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Telithromycin
  • Teriflunomide
  • Trihexyphenidyl
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