Retapamulin

What is Retapamulin

Retapamulin is a topical pleuromutilin antibiotic indicated for the treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible isolates only) and Streptococcus pyogenes.

It is a semisynthetic derivative of the compound pleuromutilin, which is isolated through fermentation from Clitopilus passeckerianus.

Retapamulin ointment application twice daily for 5 days was shown to be at least as effective as 10 days of twice-daily oral cephalexin for the treatment of secondarily infected traumatic skin lesions.

Absorption in pediatric patients may be greater than adult patients. Safety in patients younger than 9 months has not been established.

Brand Name

ALTABAX

Indications

  • impetigo
  • Staphylococcus aureus (MSSA)
  • Streptococcus pyogenes (group A beta-hemolytic streptococci)

Side Effects

  1. contact dermatitis
  2. diarrhea
  3. eczema vaccinatum
  4. erythema
  5. fever
  6. headache
  7. nausea
  8. pharyngitis
  9. pruritus
  10. skin irritation

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • ophthalmic administration
  • pregnancy
  • vaginal administration

Interactions

  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Atazanavir
  • Atazanavir; Cobicistat
  • Ceritinib
  • Chloramphenicol
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Fosamprenavir
  • grapefruit juice
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lopinavir; Ritonavir
  • Mifepristone
  • Nefazodone
  • Nelfinavir
  • Ombitasvir; Paritaprevir; Ritonavir
  • Posaconazole
  • Ribociclib
  • Ribociclib; Letrozole
  • Ritonavir
  • Saquinavir
  • Telithromycin
  • Tipranavir
  • Tucatinib
  • Voriconazole