Vortioxetine

Vortioxetine Brand Names

  • BRINTELLIX
  • Trintellix

What is Vortioxetine

Vortioxetine is a pharmacologically distinct oral antidepressant and is sometimes called a serotonin modulator and stimulator.

Vortioxetine exerts its therapeutic effects through modulation of presynaptic and postsynaptic central serotonin receptor activity.

Vortioxetine is used for the treatment of major depressive disorder in adults.

Similar to other antidepressants, the product label of vortioxetine contains a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy when treating depression or other conditions; therefore, the necessity of pharmacologic therapy versus the potential risks should be carefully considered in these populations.

Indications

  • depression

Side Effects

  1. abnormal dreams
  2. anaphylactoid reactions
  3. angioedema
  4. bleeding
  5. constipation
  6. depression
  7. diarrhea
  8. dizziness
  9. dysgeusia
  10. dyspepsia
  11. ecchymosis
  12. ejaculation dysfunction
  13. epistaxis
  14. flatulence
  15. flushing
  16. GI bleeding
  17. hematoma
  18. hyponatremia
  19. impotence (erectile dysfunction)
  20. libido decrease
  21. mania
  22. nausea
  23. neonatal abstinence syndrome
  24. orgasm dysfunction
  25. pancreatitis
  26. persistent pulmonary hypertension of the newborn
  27. petechiae
  28. platelet dysfunction
  29. pruritus
  30. rash
  31. seizures
  32. serotonin syndrome
  33. SIADH
  34. suicidal ideation
  35. urticaria
  36. vertigo
  37. vomiting
  38. weight gain
  39. withdrawal
  40. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • anticoagulant therapy
  • bipolar disorder
  • bleeding
  • breast-feeding
  • children
  • closed-angle glaucoma
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • hyponatremia
  • hypovolemia
  • increased intraocular pressure
  • infants
  • mania
  • MAOI therapy
  • neonates
  • poor metabolizers
  • pregnancy
  • seizure disorder
  • seizures
  • suicidal ideation
  • thrombolytic therapy

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Alfentanil
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Almotriptan
  • Alteplase
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amobarbital
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Anagrelide
  • Anticoagulants
  • Antithrombin III
  • Apalutamide
  • Apixaban
  • Argatroban
  • Artemether; Lumefantrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atenolol; Chlorthalidone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Betrixaban
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bivalirudin
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine; Ergotamine
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Celecoxib
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Cinacalcet
  • Citalopram
  • Clomipramine
  • Clopidogrel
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dabigatran
  • Dacomitinib
  • Dalteparin
  • Danaparoid
  • Desipramine
  • Desirudin
  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Diuretics
  • Doxepin
  • Duloxetine
  • Edoxaban
  • Eletriptan
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enoxaparin
  • Enzalutamide
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Escitalopram
  • Esomeprazole; Naproxen
  • Ethacrynic Acid
  • Ethanol
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Frovatriptan
  • Furosemide
  • Granisetron
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Heparin
  • Homatropine; Hydrocodone
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Imipramine
  • Indapamide
  • Indomethacin
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lasmiditan
  • Lepirudin
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Magnesium Salicylate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyclothiazide
  • Methylene Blue
  • Methylergonovine
  • Methylphenidate
  • Methysergide
  • Metolazone
  • Milnacipran
  • Mirtazapine
  • Mitotane
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabumetone
  • Nalbuphine
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nefazodone
  • Nonsteroidal antiinflammatory drugs
  • Nortriptyline
  • Oxaprozin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Pentosan
  • Pergolide
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenytoin
  • Piroxicam
  • Platelet Inhibitors
  • Prasugrel
  • Primidone
  • Procarbazine
  • Protriptyline
  • Quinidine
  • Rasagiline
  • Remifentanil
  • Reteplase, r-PA
  • Rifampin
  • Rivaroxaban
  • Rizatriptan
  • Rofecoxib
  • Rolapitant
  • Safinamide
  • Salicylates
  • Salsalate
  • Secobarbital
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sibutramine
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptokinase
  • Sufentanil
  • Sulindac
  • Sumatriptan
  • Tapentadol
  • Tedizolid
  • Tenecteplase
  • Thiopental
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tipranavir
  • Tirofiban
  • Tolmetin
  • Torsemide
  • Tramadol
  • Trazodone
  • Triamterene
  • Tricyclic antidepressants
  • Trimipramine
  • Urokinase
  • Valdecoxib
  • Valerian, Valeriana officinalis
  • Venlafaxine
  • Vilazodone
  • Vorapaxar
  • Warfarin
  • Zolmitriptan
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top