Vortioxetine Brand Names
- BRINTELLIX
- Trintellix
What is Vortioxetine
Vortioxetine is a pharmacologically distinct oral antidepressant and is sometimes called a serotonin modulator and stimulator.
Vortioxetine exerts its therapeutic effects through modulation of presynaptic and postsynaptic central serotonin receptor activity.
Vortioxetine is used for the treatment of major depressive disorder in adults.
Similar to other antidepressants, the product label of vortioxetine contains a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy when treating depression or other conditions; therefore, the necessity of pharmacologic therapy versus the potential risks should be carefully considered in these populations.
Indications
- depression
Side Effects
- abnormal dreams
- anaphylactoid reactions
- angioedema
- bleeding
- constipation
- depression
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- ecchymosis
- ejaculation dysfunction
- epistaxis
- flatulence
- flushing
- GI bleeding
- hematoma
- hyponatremia
- impotence (erectile dysfunction)
- libido decrease
- mania
- nausea
- neonatal abstinence syndrome
- orgasm dysfunction
- pancreatitis
- persistent pulmonary hypertension of the newborn
- petechiae
- platelet dysfunction
- pruritus
- rash
- seizures
- serotonin syndrome
- SIADH
- suicidal ideation
- urticaria
- vertigo
- vomiting
- weight gain
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- anticoagulant therapy
- bipolar disorder
- bleeding
- breast-feeding
- children
- closed-angle glaucoma
- driving or operating machinery
- geriatric
- hepatic disease
- hyponatremia
- hypovolemia
- increased intraocular pressure
- infants
- mania
- MAOI therapy
- neonates
- poor metabolizers
- pregnancy
- seizure disorder
- seizures
- suicidal ideation
- thrombolytic therapy
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alteplase
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anagrelide
- Anticoagulants
- Antithrombin III
- Apalutamide
- Apixaban
- Argatroban
- Artemether; Lumefantrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Betrixaban
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bivalirudin
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine; Ergotamine
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Celecoxib
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Cinacalcet
- Citalopram
- Clomipramine
- Clopidogrel
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dabigatran
- Dacomitinib
- Dalteparin
- Danaparoid
- Desipramine
- Desirudin
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Diuretics
- Doxepin
- Duloxetine
- Edoxaban
- Eletriptan
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Enzalutamide
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Escitalopram
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Ethanol
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Frovatriptan
- Furosemide
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Heparin
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Imipramine
- Indapamide
- Indomethacin
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lasmiditan
- Lepirudin
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Magnesium Salicylate
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methyclothiazide
- Methylene Blue
- Methylergonovine
- Methylphenidate
- Methysergide
- Metolazone
- Milnacipran
- Mirtazapine
- Mitotane
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Nalbuphine
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nefazodone
- Nonsteroidal antiinflammatory drugs
- Nortriptyline
- Oxaprozin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Pentosan
- Pergolide
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenytoin
- Piroxicam
- Platelet Inhibitors
- Prasugrel
- Primidone
- Procarbazine
- Protriptyline
- Quinidine
- Rasagiline
- Remifentanil
- Reteplase, r-PA
- Rifampin
- Rivaroxaban
- Rizatriptan
- Rofecoxib
- Rolapitant
- Safinamide
- Salicylates
- Salsalate
- Secobarbital
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptokinase
- Sufentanil
- Sulindac
- Sumatriptan
- Tapentadol
- Tedizolid
- Tenecteplase
- Thiopental
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tipranavir
- Tirofiban
- Tolmetin
- Torsemide
- Tramadol
- Trazodone
- Triamterene
- Tricyclic antidepressants
- Trimipramine
- Urokinase
- Valdecoxib
- Valerian, Valeriana officinalis
- Venlafaxine
- Vilazodone
- Vorapaxar
- Warfarin
- Zolmitriptan
