Vorinostat

Vorinostat Brand Name

Zolinza

What is Vorinostat

Vorinostat is a histone deacetylase (HDAC) inhibitor. It is indicated for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following 2 systemic therapies.

Pulmonary embolism (PE) and deep vein thrombosis (DVT) have been reported with vorinostat therapy; monitor patients for signs and symptoms of PE/DVT.

Indications

  • cutaneous T-cell lymphoma (CTCL)
  • multiple myeloma

For the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have progressive, persistent, or recurrent disease on or following 2 systemic therapies

Side Effects

  1. alopecia
  2. anemia
  3. anemia
  4. angioedema
  5. anorexia
  6. anorexia
  7. asthenia
  8. blurred vision
  9. chest pain (unspecified)
  10. chills
  11. chills
  12. cholecystitis
  13. constipation
  14. cough
  15. dehydration
  16. diarrhea
  17. dizziness
  18. dizziness
  19. dysgeusia
  20. exfoliative dermatitis
  21. fatigue
  22. fatigue
  23. fever
  24. fever
  25. gastrointestinal fistula
  26. GI bleeding
  27. GI perforation
  28. Guillain-Barre syndrome
  29. headache
  30. hemoptysis
  31. hyperglycemia
  32. hyperglycemia
  33. hypertension
  34. hypokalemia
  35. hyponatremia
  36. impaired wound healing
  37. infection
  38. lethargy
  39. leukopenia
  40. muscle cramps
  41. muscle cramps
  42. myocardial infarction
  43. nausea
  44. nausea
  45. neutropenia
  46. new primary malignancy
  47. peripheral edema
  48. proteinuria
  49. pruritus
  50. pruritus
  51. pulmonary embolism
  52. QT prolongation
  53. QT prolongation
  54. renal failure (unspecified)
  55. stroke
  56. syncope
  57. thrombocytopenia
  58. thrombocytopenia
  59. thrombosis
  60. urinary retention
  61. vasculitis
  62. vomiting
  63. vomiting
  64. weight loss
  65. weight loss
  66. xerosis

Monitoring Parameters

  • blood glucose
  • CBC with differential
  • LFTs
  • pregnancy testing
  • serum creatinine
  • serum electrolytes

Contraindications

  • accidental exposure
  • alcoholism
  • anemia
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • contraception requirements
  • coronary artery disease
  • dehydration
  • diabetes mellitus
  • diarrhea
  • electrolyte imbalance
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hyperglycemia
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • infertility
  • long QT syndrome
  • male-mediated teratogenicity
  • malnutrition
  • myocardial infarction
  • nausea/vomiting
  • pregnancy
  • pregnancy testing
  • QT prolongation
  • renal impairment
  • reproductive risk
  • thrombocytopenia
  • thromboembolic disease
  • thyroid disease

Interactions

  • Abarelix
  • Abciximab
  • Aclidinium; Formoterol
  • Albuterol
  • Albuterol; Ipratropium
  • Alfuzosin
  • Amiodarone
  • Amlodipine; Celecoxib
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Antithrombin III
  • Apixaban
  • Apomorphine
  • Ardeparin
  • Arformoterol
  • Argatroban
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Dipyridamole
  • Atomoxetine
  • Azithromycin
  • Bedaquiline
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bivalirudin
  • Budesonide; Formoterol
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Carbonic anhydrase inhibitors
  • Celecoxib
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Cilostazol
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clopidogrel
  • Clozapine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Corticosteroids
  • Crizotinib
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Desflurane
  • Desirudin
  • Deutetrabenazine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Digoxin
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Dronedarone
  • Droperidol
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Enflurane
  • Enoxaparin
  • Entrectinib
  • Eptifibatide
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esomeprazole; Naproxen
  • Etodolac
  • Ezogabine
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurbiprofen
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Fondaparinux
  • Formoterol
  • Formoterol; Mometasone
  • Foscarnet
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Glasdegib
  • Glycopyrrolate; Formoterol
  • Goserelin
  • Granisetron
  • Halofantrine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Histrelin
  • Hydrocodone; Ibuprofen
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Ibutilide
  • Iloperidone
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Inotuzumab Ozogamicin
  • Isoflurane
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Lepirudin
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levalbuterol
  • Levofloxacin
  • Levomethadyl
  • Lithium
  • Lofexidine
  • Long-acting beta-agonists
  • Loop diuretics
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Low Molecular Weight Heparins
  • Macimorelin
  • Maprotiline
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Meperidine; Promethazine
  • Mesoridazine
  • Metaproterenol
  • Methadone
  • Metronidazole
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Moxifloxacin
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nilotinib
  • Nonsteroidal antiinflammatory drugs
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olodaterol
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxaprozin
  • Ozanimod
  • Palifermin
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Penicillamine
  • Pentamidine
  • Pentosan
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenylephrine; Promethazine
  • Pimavanserin
  • Pimozide
  • Pirbuterol
  • Piroxicam
  • Pitolisant
  • Posaconazole
  • Prasugrel
  • Primaquine
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Romidepsin
  • Salmeterol
  • Saquinavir
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Short-acting beta-agonists
  • Siponimod
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Sulindac
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telavancin
  • Telithromycin
  • Terbutaline
  • Tetrabenazine
  • Thiazide diuretics
  • Thioridazine
  • Thrombin Inhibitors
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tiotropium; Olodaterol
  • Tolmetin
  • Tolterodine
  • Toremifene
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Triptorelin
  • Tuberculin Purified Protein Derivative, PPD
  • Umeclidinium; Vilanterol
  • Valdecoxib
  • Valproic Acid, Divalproex Sodium
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vorapaxar
  • Voriconazole
  • Warfarin
  • Ziprasidone
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