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Vorinostat Brand Name
Zolinza
What is Vorinostat
Vorinostat is a histone deacetylase (HDAC) inhibitor. It is indicated for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following 2 systemic therapies.
Pulmonary embolism (PE) and deep vein thrombosis (DVT) have been reported with vorinostat therapy; monitor patients for signs and symptoms of PE/DVT.
Indications
- cutaneous T-cell lymphoma (CTCL)
- multiple myeloma
For the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have progressive, persistent, or recurrent disease on or following 2 systemic therapies
Side Effects
- alopecia
- anemia
- anemia
- angioedema
- anorexia
- anorexia
- asthenia
- blurred vision
- chest pain (unspecified)
- chills
- chills
- cholecystitis
- constipation
- cough
- dehydration
- diarrhea
- dizziness
- dizziness
- dysgeusia
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- gastrointestinal fistula
- GI bleeding
- GI perforation
- Guillain-Barre syndrome
- headache
- hemoptysis
- hyperglycemia
- hyperglycemia
- hypertension
- hypokalemia
- hyponatremia
- impaired wound healing
- infection
- lethargy
- leukopenia
- muscle cramps
- muscle cramps
- myocardial infarction
- nausea
- nausea
- neutropenia
- new primary malignancy
- peripheral edema
- proteinuria
- pruritus
- pruritus
- pulmonary embolism
- QT prolongation
- QT prolongation
- renal failure (unspecified)
- stroke
- syncope
- thrombocytopenia
- thrombocytopenia
- thrombosis
- urinary retention
- vasculitis
- vomiting
- vomiting
- weight loss
- weight loss
- xerosis
Monitoring Parameters
- blood glucose
- CBC with differential
- LFTs
- pregnancy testing
- serum creatinine
- serum electrolytes
Contraindications
- accidental exposure
- alcoholism
- anemia
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- contraception requirements
- coronary artery disease
- dehydration
- diabetes mellitus
- diarrhea
- electrolyte imbalance
- females
- geriatric
- heart failure
- hepatic disease
- hyperglycemia
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infertility
- long QT syndrome
- male-mediated teratogenicity
- malnutrition
- myocardial infarction
- nausea/vomiting
- pregnancy
- pregnancy testing
- QT prolongation
- renal impairment
- reproductive risk
- thrombocytopenia
- thromboembolic disease
- thyroid disease
Interactions
- Abarelix
- Abciximab
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Antithrombin III
- Apixaban
- Apomorphine
- Ardeparin
- Arformoterol
- Argatroban
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Dipyridamole
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bivalirudin
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Carbonic anhydrase inhibitors
- Celecoxib
- Ceritinib
- Chloroquine
- Chlorpromazine
- Cilostazol
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clopidogrel
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Corticosteroids
- Crizotinib
- Dabigatran
- Dalteparin
- Danaparoid
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Desflurane
- Desirudin
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dronedarone
- Droperidol
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Enoxaparin
- Entrectinib
- Eptifibatide
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole; Naproxen
- Etodolac
- Ezogabine
- Famotidine; Ibuprofen
- Fenoprofen
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Heparin
- Histrelin
- Hydrocodone; Ibuprofen
- Hydroxychloroquine
- Hydroxyzine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Iloperidone
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indomethacin
- Inotuzumab Ozogamicin
- Isoflurane
- Itraconazole
- Ivosidenib
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Lefamulin
- Lenvatinib
- Lepirudin
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Levomethadyl
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Low Molecular Weight Heparins
- Macimorelin
- Maprotiline
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Meperidine; Promethazine
- Mesoridazine
- Metaproterenol
- Methadone
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Moxifloxacin
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nilotinib
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Ozanimod
- Palifermin
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penicillamine
- Pentamidine
- Pentosan
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Piroxicam
- Pitolisant
- Posaconazole
- Prasugrel
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Sulindac
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thiazide diuretics
- Thioridazine
- Thrombin Inhibitors
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tiotropium; Olodaterol
- Tolmetin
- Tolterodine
- Toremifene
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Triptorelin
- Tuberculin Purified Protein Derivative, PPD
- Umeclidinium; Vilanterol
- Valdecoxib
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vorapaxar
- Voriconazole
- Warfarin
- Ziprasidone