Sulfacetamide

What is Sulfacetamide

Sulfacetamide is a synthetic sulfonamide antibiotic for ophthalmic or topical administration.

Sulfacetamide, because it is water soluble and because a 30% solution has a pH of 7.4, is an ideal sulfonamide for ophthalmic administration. Despite the favorable pharmaceutical properties, use of sulfonamides in general has declined due to development of resistance.

Sulfacetamide is used topically for the treatment of acne, scaling dermatoses such as seborrheic dermatitis and seborrheic sicca, and also for topical bacterial skin infection caused by susceptible organisms.

Sulfacetamide was approved by the FDA in 1946 for the treatment of conjunctivitis, corneal ulcers and other superficial eye infections caused by susceptible organisms.

Indications

  • acne vulgaris
  • Actinomyces sp.
  • Chlamydia trachomatis
  • chlamydial conjunctivitis
  • corneal ulcer
  • Enterobacter sp.
  • Escherichia coli
  • Haemophilus influenzae (beta-lactamase negative)
  • Haemophilus influenzae (beta-lactamase positive)
  • Klebsiella pneumoniae
  • Klebsiella sp.
  • Nocardia sp.
  • Proteus vulgaris
  • Salmonella sp.
  • seborrhea sicca
  • seborrheic dermatitis
  • skin and skin structure infections
  • Staphylococcus aureus (MSSA)
  • Streptococcus pneumoniae
  • Streptococcus pyogenes (group A beta-hemolytic streptococci)
  • Streptococcus sp.
  • Viridans streptococci

Side Effects

  1. agranulocytosis
  2. aplastic anemia
  3. conjunctival hyperemia
  4. conjunctivitis
  5. edema
  6. erythema
  7. hepatic necrosis
  8. lupus-like symptoms
  9. ocular irritation
  10. pruritus
  11. skin irritation
  12. Stevens-Johnson syndrome
  13. superinfection
  14. toxic epidermal necrolysis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • carbonic anhydrase inhibitor hypersensitivity
  • children
  • fungal infection
  • infants
  • neonates
  • ocular surgery
  • ocular trauma
  • pregnancy
  • renal disease
  • sulfonamide hypersensitivity
  • sulfonylurea hypersensitivity
  • sunlight (UV) exposure
  • thiazide diuretic hypersensitivity
  • viral infection

Interactions

  • Acetohexamide
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Atenolol; Chlorthalidone
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gentamicin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Methoxsalen
  • Methyclothiazide
  • Metolazone
  • Photosensitizing agents (topical)
  • Silver Nitrate
  • Silver Sulfadiazine
  • Sulfonylureas
  • Thiazide diuretics
  • Tolazamide
  • Tolbutamide
  • Voriconazole
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