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What is Streptozocin
Streptozocin is an alkylating agent of the nitrosurea family, which includes carmustine and lomustine. It is a natural product from Streptomyces achromogenes.
Streptozocin is used in the management of pancreatic islet cell carcinoma, carcinoid tumor, colorectal cancer, and pancreatic adenocarcinoma.
It seems to have specific activity only in pancreatic cancers and some gastrointestinal tumors. The generic name is sometimes spelled streptozotocin. Streptozocin was aproved by the FDA in 1982.
Brand Name
Zanosar
Indications
- carcinoid
- colorectal cancer
- pancreatic cancer
Side Effects
- anemia
- anuria
- azotemia
- bone marrow suppression
- diabetes insipidus
- diarrhea
- edema
- elevated hepatic enzymes
- erythema
- glycosuria
- hepatotoxicity
- hypoalbuminemia
- hypoglycemia
- hypophosphatemia
- injection site reaction
- insulin shock
- leukopenia
- nausea
- nephrotoxicity
- neutropenia
- proteinuria
- renal tubular acidosis (RTA)
- skin irritation
- thrombocytopenia
- tissue necrosis
- vomiting
Monitoring Parameters
- blood glucose
- CBC with differential
- LFTs
- platelet count
- serum creatinine/BUN
- serum electrolytes
- serum phosphate
- urinalysis
Contraindications
- accidental exposure
- bone marrow suppression
- breast-feeding
- chemotherapy-induced nausea/vomiting
- dental disease
- dental work
- diabetes mellitus
- diarrhea
- driving or operating machinery
- extravasation
- hepatic disease
- hepatotoxicity
- herpes infection
- hypophosphatemia
- infection
- intramuscular administration
- intramuscular injections
- nephrotoxicity
- neutropenia
- new primary malignancy
- ocular exposure
- pregnancy
- proteinuria
- renal disease
- renal failure
- renal impairment
- requires a specialized care setting
- requires an experienced clinician
- subcutaneous administration
- thrombocytopenia
- tumorigenicity
- vaccination
- varicella
- viral infection
Interactions
- Aldesleukin, IL-2
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Atenolol; Chlorthalidone
- Azilsartan; Chlorthalidone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bumetanide
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Celecoxib
- Chlorothiazide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cisplatin
- Clozapine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Doxorubicin
- Doxorubicin Liposomal
- Echinacea
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Etodolac
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Flucytosine
- Flurbiprofen
- Foscarnet
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Furosemide
- Gentamicin
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Immune Globulin IV, IVIG, IGIV
- Indomethacin
- Kanamycin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Live Vaccines
- Loop diuretics
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methyclothiazide
- Metolazone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Paromomycin
- Pegfilgrastim
- Penicillamine
- Phenytoin
- Piroxicam
- Plazomicin
- Potassium-sparing diuretics
- Rofecoxib
- Spironolactone
- Streptomycin
- Sulindac
- Telavancin
- Thiazide diuretics
- Tobramycin
- Tolmetin
- Torsemide
- Triamterene
- Tuberculin Purified Protein Derivative, PPD
- Valdecoxib
- Vancomycin
