Vilazodone

Vilazodone Brand Name

VIIBRYD

What is Vilazodone

Vilazodone is an oral antidepressant that is a dual selective serotonin reuptake inhibitor and partial serotonin 5-HT1A agonist and is often described as a serotonin modulator.

Vilazodone is used for the treatment of major depressive disorder in adults.

Vilazodone is extensively metabolized in the liver, and dosage adjustments are recommended during concurrent use with strong CYP3A4 inhibitors or inducers.

Similar to other antidepressants, product labels for all antidepressants contain a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy; therefore, the necessity of pharmacologic therapy versus the potential risks should be carefully considered in these populations.

Indications

  • depression

Side Effects

  1. abnormal dreams
  2. akathisia
  3. anorexia
  4. anxiety
  5. appetite stimulation
  6. arthralgia
  7. bleeding
  8. blurred vision
  9. cataracts
  10. depression
  11. diarrhea
  12. dizziness
  13. drowsiness
  14. dysgeusia
  15. dyspepsia
  16. ecchymosis
  17. ejaculation dysfunction
  18. epistaxis
  19. fatigue
  20. flatulence
  21. GI bleeding
  22. hallucinations
  23. headache
  24. hematoma
  25. hyperhidrosis
  26. hyponatremia
  27. impotence (erectile dysfunction)
  28. insomnia
  29. irritability
  30. libido decrease
  31. mania
  32. migraine
  33. nausea
  34. neonatal abstinence syndrome
  35. night sweats
  36. ocular hypertension
  37. orgasm dysfunction
  38. palpitations
  39. pancreatitis
  40. paresthesias
  41. persistent pulmonary hypertension of the newborn
  42. petechiae
  43. platelet dysfunction
  44. rash
  45. restless legs syndrome (RLS)
  46. restlessness
  47. seizures
  48. serotonin syndrome
  49. SIADH
  50. sleep paralysis
  51. suicidal ideation
  52. tremor
  53. urticaria
  54. vomiting
  55. withdrawal
  56. xerophthalmia
  57. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • anticoagulant therapy
  • bipolar disorder
  • bleeding
  • breast-feeding
  • children
  • closed-angle glaucoma
  • dehydration
  • driving or operating machinery
  • electroconvulsive therapy (ECT)
  • ethanol ingestion
  • geriatric
  • hepatic disease
  • hyponatremia
  • hypovolemia
  • increased intraocular pressure
  • labor
  • mania
  • MAOI therapy
  • neonates
  • obstetric delivery
  • pregnancy
  • seizure disorder
  • seizures
  • substance abuse
  • suicidal ideation
  • thrombolytic therapy

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alprazolam
  • Alteplase
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamines
  • Anagrelide
  • Anticoagulants
  • Antithrombin III
  • Anxiolytics; Sedatives; and Hypnotics
  • Apalutamide
  • Apixaban
  • Argatroban
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betrixaban
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bivalirudin
  • Boceprevir
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Caffeine; Ergotamine
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Celecoxib
  • Ceritinib
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chloral Hydrate
  • Chloramphenicol
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clonazepam
  • Clopidogrel
  • Clorazepate
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desirudin
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
  • Dolasetron
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Edoxaban
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enoxaparin
  • Enzalutamide
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Escitalopram
  • Esomeprazole; Naproxen
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosamprenavir
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Furosemide
  • Granisetron
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Heparin
  • Homatropine; Hydrocodone
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Idelalisib
  • Indinavir
  • Indomethacin
  • Isocarboxazid
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lasmiditan
  • Lepirudin
  • Letermovir
  • Levorphanol
  • Linezolid
  • Lithium
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lumacaftor; Ivacaftor
  • Magnesium Salicylate
  • Meclizine
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methyclothiazide
  • Methylene Blue
  • Methylergonovine
  • Methylphenidate
  • Methysergide
  • Metolazone
  • Midazolam
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nabumetone
  • Nalbuphine
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nonsteroidal antiinflammatory drugs
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Oxaprozin
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Palonosetron
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentosan
  • Pergolide
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenytoin
  • Piroxicam
  • Platelet Inhibitors
  • Posaconazole
  • Potassium-sparing diuretics
  • Prasugrel
  • Primidone
  • Procarbazine
  • Propoxyphene
  • Quazepam
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Reteplase, r-PA
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Safinamide
  • Salicylates
  • Salsalate
  • Saquinavir
  • Sedating H1-blockers
  • Selegiline
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sibutramine
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptokinase
  • Sufentanil
  • Sulindac
  • Tapentadol
  • Tedizolid
  • Telaprevir
  • Telithromycin
  • Temazepam
  • Tenecteplase
  • Thiazide diuretics
  • Thioridazine
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tipranavir
  • Tirofiban
  • Tolmetin
  • Torsemide
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Triprolidine
  • Tucatinib
  • Urokinase
  • Valdecoxib
  • Valerian, Valeriana officinalis
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Warfarin
  • Zaleplon
  • Zolpidem
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