What's on this Page
Vilazodone Brand Name
VIIBRYD
What is Vilazodone
Vilazodone is an oral antidepressant that is a dual selective serotonin reuptake inhibitor and partial serotonin 5-HT1A agonist and is often described as a serotonin modulator.
Vilazodone is used for the treatment of major depressive disorder in adults.
Vilazodone is extensively metabolized in the liver, and dosage adjustments are recommended during concurrent use with strong CYP3A4 inhibitors or inducers.
Similar to other antidepressants, product labels for all antidepressants contain a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy; therefore, the necessity of pharmacologic therapy versus the potential risks should be carefully considered in these populations.
Indications
- depression
Side Effects
- abnormal dreams
- akathisia
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- bleeding
- blurred vision
- cataracts
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- ecchymosis
- ejaculation dysfunction
- epistaxis
- fatigue
- flatulence
- GI bleeding
- hallucinations
- headache
- hematoma
- hyperhidrosis
- hyponatremia
- impotence (erectile dysfunction)
- insomnia
- irritability
- libido decrease
- mania
- migraine
- nausea
- neonatal abstinence syndrome
- night sweats
- ocular hypertension
- orgasm dysfunction
- palpitations
- pancreatitis
- paresthesias
- persistent pulmonary hypertension of the newborn
- petechiae
- platelet dysfunction
- rash
- restless legs syndrome (RLS)
- restlessness
- seizures
- serotonin syndrome
- SIADH
- sleep paralysis
- suicidal ideation
- tremor
- urticaria
- vomiting
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- anticoagulant therapy
- bipolar disorder
- bleeding
- breast-feeding
- children
- closed-angle glaucoma
- dehydration
- driving or operating machinery
- electroconvulsive therapy (ECT)
- ethanol ingestion
- geriatric
- hepatic disease
- hyponatremia
- hypovolemia
- increased intraocular pressure
- labor
- mania
- MAOI therapy
- neonates
- obstetric delivery
- pregnancy
- seizure disorder
- seizures
- substance abuse
- suicidal ideation
- thrombolytic therapy
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alprazolam
- Alteplase
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamines
- Anagrelide
- Anticoagulants
- Antithrombin III
- Anxiolytics; Sedatives; and Hypnotics
- Apalutamide
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Betrixaban
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bivalirudin
- Boceprevir
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butorphanol
- Caffeine; Ergotamine
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Celecoxib
- Ceritinib
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Citalopram
- Clarithromycin
- Clemastine
- Clonazepam
- Clopidogrel
- Clorazepate
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dabigatran
- Dalteparin
- Danaparoid
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desirudin
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Dolasetron
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Edoxaban
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Enzalutamide
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Escitalopram
- Esomeprazole; Naproxen
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Fosamprenavir
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Furosemide
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Heparin
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Indinavir
- Indomethacin
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lasmiditan
- Lepirudin
- Letermovir
- Levorphanol
- Linezolid
- Lithium
- Loop diuretics
- Lopinavir; Ritonavir
- Lorazepam
- Lumacaftor; Ivacaftor
- Magnesium Salicylate
- Meclizine
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Meperidine
- Meperidine; Promethazine
- Meprobamate
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methyclothiazide
- Methylene Blue
- Methylergonovine
- Methylphenidate
- Methysergide
- Metolazone
- Midazolam
- Mirabegron
- Mirtazapine
- Mitotane
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nabumetone
- Nalbuphine
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nonsteroidal antiinflammatory drugs
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Oxaprozin
- Oxazepam
- Oxycodone
- Oxymorphone
- Ozanimod
- Palonosetron
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pentosan
- Pergolide
- Phenelzine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenytoin
- Piroxicam
- Platelet Inhibitors
- Posaconazole
- Potassium-sparing diuretics
- Prasugrel
- Primidone
- Procarbazine
- Propoxyphene
- Quazepam
- Ramelteon
- Rasagiline
- Remifentanil
- Reteplase, r-PA
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Safinamide
- Salicylates
- Salsalate
- Saquinavir
- Sedating H1-blockers
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptokinase
- Sufentanil
- Sulindac
- Tapentadol
- Tedizolid
- Telaprevir
- Telithromycin
- Temazepam
- Tenecteplase
- Thiazide diuretics
- Thioridazine
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tipranavir
- Tirofiban
- Tolmetin
- Torsemide
- Tramadol
- Tranylcypromine
- Trazodone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Triprolidine
- Tucatinib
- Urokinase
- Valdecoxib
- Valerian, Valeriana officinalis
- Vorapaxar
- Voriconazole
- Vortioxetine
- Warfarin
- Zaleplon
- Zolpidem