Tegaserod

What is Tegaserod

Tegaserod is a selective serotonin (5HT-4) partial agonist belonging to a chemical class known as the aminoguanidine indoles.

Tegaserod is indicated for the treatment of adult women less than 65 years of age with irritable bowel syndrome with constipation (IBS-C).

Tegaserod has been shown to be effective in treating abdominal pain, altered bowel habit (decreased stool frequency, hardened stool consistency, straining), and bloating associated with constipation-predominant IBS

Brand Name

Zelnorm

Indications

  • irritable bowel syndrome

For the treatment irritable bowel syndrome (IBS) in women whose predominant bowel symptom is constipation

Side Effects

  1. abdominal pain
  2. alopecia
  3. anaphylactoid reactions
  4. anemia
  5. appetite stimulation
  6. arthropathy
  7. asthenia
  8. bowel ischemia
  9. bowel necrosis
  10. chest pain (unspecified)
  11. cholecystitis
  12. cholelithiasis
  13. colitis
  14. depression
  15. diarrhea
  16. dizziness
  17. dyspepsia
  18. elevated hepatic enzymes
  19. flatulence
  20. GI bleeding
  21. headache
  22. hepatitis
  23. hypokalemia
  24. ischemic colitis
  25. migraine
  26. myocardial infarction
  27. nausea
  28. orthostatic hypotension
  29. stroke
  30. suicidal ideation
  31. syncope
  32. vertigo

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abdominal pain
  • angina
  • breast-feeding
  • cardiac disease
  • children
  • colitis
  • coronary artery disease
  • depression
  • diabetes mellitus
  • diarrhea
  • gallbladder disease
  • geriatric
  • GI bleeding
  • GI disease
  • GI obstruction
  • hepatic disease
  • hyperlipidemia
  • hypertension
  • hypotension
  • hypovolemia
  • infants
  • ischemic colitis
  • myocardial infarction
  • neonates
  • obesity
  • pregnancy
  • renal disease
  • renal impairment
  • stroke
  • suicidal ideation
  • syncope
  • tobacco smoking

Interactions

  • Acarbose
  • Acetohexamide
  • Albiglutide
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Anticholinergics
  • Atenolol; Chlorthalidone
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Digoxin
  • Dulaglutide
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Exenatide
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Incretin Mimetics
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Linagliptin
  • Linagliptin; Metformin
  • Liraglutide
  • Lixisenatide
  • Meglitinides
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methyclothiazide
  • Metolazone
  • Miglitol
  • Nateglinide
  • Pioglitazone
  • Repaglinide
  • Rosiglitazone
  • Saxagliptin
  • Semaglutide
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Solifenacin
  • Sulfonylureas
  • Thiazide diuretics
  • Tolazamide
  • Tolbutamide
  • Tolterodine
  • Trospium
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