Vinblastine Brand Name
Velban
What is Vinblastine
Vinblastine is a member of the vinca alkaloid class of naturally occurring cancer chemotherapy agents, which are extracted from the Catharanthus rosea or periwinkle plant.
Vinblastine is similar to vincristine in action and structure, but their toxicities and spectrum of activity differ significantly.
Vinblastine has the shortest terminal half-life and highest clearance of all available vinca alkaloids.
Vinblastine is a cell cycle-phase specific agent used in the management of many different malignancies including breast carcinoma, bladder carcinoma, Hodgkin lymphoma, melanoma, and testicular carcinoma. The FDA approved vinblastine in 1961.
Indications
- bladder cancer
- breast cancer
- choriocarcinoma
- cutaneous T-cell lymphoma (CTCL)
- desmoid tumor
- Hodgkin lymphoma
- Kaposi’s sarcoma
- Langerhans’ cell histiocytosis
- malignant melanoma
- mycosis fungoides
- non-Hodgkin’s lymphoma (NHL)
- non-small cell lung cancer (NSCLC)
- prostate cancer
- testicular cancer
Side Effects
- abdominal pain
- alopecia
- anemia
- angina
- anorexia
- bone pain
- bronchospasm
- constipation
- depression
- diarrhea
- dizziness
- dyspnea
- enterocolitis
- GI bleeding
- headache
- hearing loss
- hypertension
- ileus
- infection
- infertility
- injection site reaction
- leukopenia
- malaise
- muscle paralysis
- myocardial infarction
- nausea
- neuritis
- nystagmus
- oral ulceration
- paresthesias
- peptic ulcer
- pharyngitis
- phlebitis
- photosensitivity
- seizures
- SIADH
- skin irritation
- stomatitis
- stroke
- thrombocytopenia
- tissue necrosis
- vertigo
- vomiting
- weakness
Monitoring Parameters
- CBC
- LFTs
- serum bilirubin (total and direct)
- serum sodium
- serum uric acid
Contraindications
- accidental exposure
- anemia
- biliary tract disease
- bleeding
- bone marrow suppression
- breast-feeding
- dental disease
- dental work
- extravasation
- fungal infection
- hepatic disease
- herpes infection
- hyperkalemia
- hyperphosphatemia
- hyperuricemia
- hypocalcemia
- ileus
- infection
- intramuscular administration
- intramuscular injections
- intrathecal administration
- jaundice
- neurological disease
- neutropenia
- ocular exposure
- pregnancy
- radiation therapy
- requires an experienced clinician
- subcutaneous administration
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vaccination
- varicella
- viral infection
Interactions
- Acetaminophen; Propoxyphene
- Aldesleukin, IL-2
- Alpha interferons
- Amiodarone
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anticoagulants
- Antithrombin III
- Apixaban
- Aprepitant, Fosaprepitant
- Argatroban
- Atazanavir
- Atazanavir; Cobicistat
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Betrixaban
- Bivalirudin
- Bortezomib
- Budesonide
- Budesonide; Formoterol
- Carbamazepine
- Carvedilol
- Celecoxib
- Ceritinib
- Chloramphenicol
- Ciclesonide
- Clarithromycin
- Clozapine
- Cobicistat
- Conivaptan
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Crizotinib
- Cyclosporine
- Dabigatran
- Dalteparin
- Danaparoid
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Denileukin Diftitox
- Desirudin
- Dexamethasone
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diltiazem
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Echinacea
- Edoxaban
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enoxaparin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esomeprazole; Naproxen
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Etravirine
- Everolimus
- Famotidine; Ibuprofen
- Febuxostat
- Fedratinib
- Fenoprofen
- Filgrastim, G-CSF
- Fluconazole
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Gadobenate Dimeglumine
- Ganciclovir
- Glecaprevir; Pibrentasvir
- grapefruit juice
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Indinavir
- Indomethacin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interleukins
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ixabepilone
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lepirudin
- Letermovir
- Live Vaccines
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Methotrexate
- Methylprednisolone
- Mifepristone
- Mitomycin
- Mitotane
- Modafinil
- Mometasone
- Nabumetone
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nicardipine
- Nilotinib
- Nonsteroidal antiinflammatory drugs
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oprelvekin, rh-IL-11
- Oritavancin
- Oxaprozin
- Oxcarbazepine
- Palbociclib
- Palifermin
- Pazopanib
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pentosan
- Phenytoin
- Piroxicam
- Posaconazole
- Prednisolone
- Prednisone
- Propafenone
- Propoxyphene
- Quinidine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Rolapitant
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Simeprevir
- St. John’s Wort, Hypericum perforatum
- Sulindac
- Tbo-Filgrastim
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Testosterone
- Tinzaparin
- Tolmetin
- Trandolapril; Verapamil
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Tucatinib
- Valdecoxib
- Valganciclovir
- Vemurafenib
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast
