Semaglutide

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What is Semaglutide

Brand Names

  • OZEMPIC
  • Rybelsus

Indications & Dosage

  • reduction of cardiovascular mortality
  • type 2 diabetes mellitus

For the treatment of type 2 diabetes mellitus in combination with diet and exercise

Side Effects

  1. abdominal pain
  2. antibody formation
  3. cholelithiasis
  4. constipation
  5. dehydration
  6. diarrhea
  7. dizziness
  8. dysgeusia
  9. dyspepsia
  10. eructation
  11. fatigue
  12. flatulence
  13. gastritis
  14. gastroesophageal reflux
  15. hyperamylasemia
  16. hypoglycemia
  17. injection site reaction
  18. nausea
  19. new primary malignancy
  20. pancreatitis
  21. renal failure (unspecified)
  22. retinopathy
  23. vomiting

Monitoring Parameters

  • blood glucose
  • glycosylated hemoglobin A1c (HbA1c)

Contraindications

  • breast-feeding
  • burns
  • children
  • diabetic ketoacidosis
  • diabetic retinopathy
  • diarrhea
  • fever
  • geriatric
  • history of angioedema
  • hypoglycemia
  • infants
  • infection
  • medullary thyroid carcinoma (MTC)
  • multiple endocrine neoplasia syndrome type 2 (MEN 2)
  • neonates
  • pancreatitis
  • pregnancy
  • renal impairment
  • reproductive risk
  • serious hypersensitivity reactions or anaphylaxis
  • surgery
  • thyroid C-cell tumors
  • thyroid cancer
  • thyroid disease
  • trauma
  • type 1 diabetes mellitus
  • vomiting

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetazolamide
  • Aliskiren; Valsartan
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Benazepril
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Androgens
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • atypical antipsychotic
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Beta-blockers
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bortezomib
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbonic anhydrase inhibitors
  • Chloroquine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Chromium
  • Clarithromycin
  • Clonidine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticosteroids
  • Cyclosporine
  • Daclatasvir
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dextromethorphan; Promethazine
  • Diazoxide
  • Dienogest; Estradiol valerate
  • Digoxin
  • Disopyramide
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esterified Estrogens; Methyltestosterone
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Ethanol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Etonogestrel
  • Fibric acid derivatives
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluoxymesterone
  • Fluphenazine
  • Fosamprenavir
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Garlic, Allium sativum
  • Glecaprevir; Pibrentasvir
  • Green Tea
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydroxychloroquine
  • Hydroxyprogesterone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indapamide
  • Indinavir
  • Irbesartan
  • Isocarboxazid
  • Lanreotide
  • Ledipasvir; Sofosbuvir
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linezolid
  • Liothyronine
  • Lisinopril
  • Lithium
  • Lomefloxacin
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lorcaserin
  • Losartan
  • Lovastatin; Niacin
  • Magnesium Salicylate
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Medroxyprogesterone
  • Meperidine; Promethazine
  • Mesoridazine
  • Mestranol; Norethindrone
  • Methazolamide
  • Methyltestosterone
  • Metyrapone
  • Moexipril
  • Monoamine oxidase inhibitors
  • Nandrolone Decanoate
  • Nebivolol; Valsartan
  • Nelfinavir
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nicotine
  • Norethindrone
  • Norgestrel
  • Octreotide
  • Olmesartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Orlistat
  • Oxandrolone
  • Oxymetholone
  • Pasireotide
  • Pegvisomant
  • Pentamidine
  • Pentoxifylline
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Phenytoin
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prochlorperazine
  • Progesterone
  • Progestins
  • Promethazine
  • Protease inhibitors
  • Quinapril
  • Quinolones
  • Ramipril
  • Reserpine
  • Ritonavir
  • Sacubitril; Valsartan
  • Salicylates
  • Salsalate
  • Saquinavir
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Somatropin, rh-GH
  • Sparfloxacin
  • Sulfonamides
  • Sympathomimetics
  • Tacrolimus
  • Tegaserod
  • Telmisartan
  • Testolactone
  • Testosterone
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiethylperazine
  • Thioridazine
  • Thyroid hormones
  • Tipranavir
  • tobacco
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Triamterene
  • Trifluoperazine
  • Valsartan
  • Warfarin

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