Trastuzumab and Hyaluronidase oysk

What is Trastuzumab and Hyaluronidase combination medicine

Trastuzumab and hyaluronidase oysk is a combination of trastuzumab, a HER2/neu receptor antagonist, and hyaluronidase, an endoglycosidase indicated for the treatment of HER2-overexpressing breast cancer in adults.

Use should be limited to patients with documented overexpression of the HER2 protein, using FDA-approved tests specific for breast cancer; gene amplification and HER2 protein overexpression are not as well correlated in gastric cancer as they are in breast cancer.

Treatment with trastuzumab and hyaluronidase oysk can cause heart failure, with the highest incidence in patients receiving concomitant therapy with anthracyclines; monitor left ventricular function in all patients.

Brand Name

HERCEPTIN HYLECTA

Indications

  • breast cancer

For the treatment of HER2-positive breast cancer

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. acute respiratory distress syndrome (ARDS)
  4. alopecia
  5. alopecia
  6. amenorrhea
  7. anemia
  8. anemia
  9. anorexia
  10. anorexia
  11. antibody formation
  12. arrhythmia exacerbation
  13. arthralgia
  14. arthralgia
  15. back pain
  16. back pain
  17. bleeding
  18. bone pain
  19. bone pain
  20. constipation
  21. constipation
  22. cough
  23. cough
  24. diarrhea
  25. diarrhea
  26. dizziness
  27. dizziness
  28. dysgeusia
  29. dyspepsia
  30. dyspnea
  31. dyspnea
  32. edema
  33. edema
  34. elevated hepatic enzymes
  35. epistaxis
  36. erythema
  37. erythema
  38. fatigue
  39. fatigue
  40. fever
  41. fever
  42. flushing
  43. flushing
  44. glomerulonephritis
  45. headache
  46. headache
  47. heart failure
  48. hematoma
  49. hot flashes
  50. hypertension
  51. hypertension
  52. hypoxia
  53. infection
  54. infection
  55. injection site reaction
  56. injection site reaction
  57. insomnia
  58. insomnia
  59. leukopenia
  60. leukopenia
  61. myalgia
  62. myalgia
  63. nasal irritation
  64. nausea
  65. nausea
  66. neutropenia
  67. neutropenia
  68. oligomenorrhea
  69. paresthesias
  70. paresthesias
  71. peripheral edema
  72. peripheral neuropathy
  73. peripheral neuropathy
  74. pleural effusion
  75. pneumonitis
  76. pruritus
  77. pulmonary edema
  78. pulmonary fibrosis
  79. pulmonary toxicity
  80. rash
  81. rash
  82. serious hypersensitivity reactions or anaphylaxis
  83. sinus tachycardia
  84. skin discoloration
  85. teratogenesis
  86. thrombocytopenia
  87. tumor lysis syndrome (TLS)
  88. vomiting
  89. vomiting

Monitoring Parameters

  • echocardiogram
  • multi-gated radionuclide angiography (MUGA)
  • pregnancy testing

Contraindications

  • asthma
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • chemotherapy
  • chronic obstructive pulmonary disease (COPD)
  • contraception requirements
  • ensure correct formulation selection
  • geriatric
  • heart failure
  • hypertension
  • neutropenia
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • pulmonary fibrosis
  • pulmonary toxicity
  • reproductive risk
  • serious hypersensitivity reactions or anaphylaxis

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Amide local anesthetics
  • Aminosalicylate sodium, Aminosalicylic acid
  • Anthracyclines
  • Articaine; Epinephrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Chloroprocaine
  • Choline Salicylate; Magnesium Salicylate
  • Cocaine
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticotropin, ACTH
  • Cortisone
  • Daunorubicin
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Doxorubicin
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Epirubicin
  • Ester local anesthetics
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Idarubicin
  • Levobupivacaine
  • Lidocaine
  • Lidocaine; Prilocaine
  • Magnesium Salicylate
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Palifermin
  • Penicillamine
  • Prilocaine
  • Prilocaine; Epinephrine
  • Procaine
  • Ropivacaine
  • Salicylates
  • Salsalate
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Tetracaine
  • Tuberculin Purified Protein Derivative, PPD
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