Trastuzumab

What is Trastuzumab

Indications

  • breast cancer
  • gastric cancer

For the treatment of patients with HER2-positive breast cancer

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. acute respiratory distress syndrome (ARDS)
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. anemia
  7. anemia
  8. angioedema
  9. anorexia
  10. antibody formation
  11. arthralgia
  12. asthenia
  13. back pain
  14. bone pain
  15. cardiomyopathy
  16. chills
  17. chills
  18. constipation
  19. cough
  20. depression
  21. diarrhea
  22. dizziness
  23. dysgeusia
  24. dyspepsia
  25. dysphagia
  26. dyspnea
  27. edema
  28. epistaxis
  29. fatigue
  30. fatigue
  31. fever
  32. fever
  33. glomerulonephritis
  34. headache
  35. heart failure
  36. hot flashes
  37. hyperphosphatemia
  38. hypertension
  39. hyperuricemia
  40. hypokalemia
  41. hypokalemia
  42. hypotension
  43. hypoxia
  44. infection
  45. infection
  46. influenza
  47. infusion-related reactions
  48. infusion-related reactions
  49. insomnia
  50. leukopenia
  51. myalgia
  52. myocardial infarction
  53. nausea
  54. nephrotic syndrome
  55. neuritis
  56. neutropenia
  57. neutropenia
  58. palpitations
  59. paresthesias
  60. peripheral edema
  61. peripheral neuropathy
  62. pharyngitis
  63. pleural effusion
  64. pneumonitis
  65. pruritus
  66. pulmonary edema
  67. pulmonary fibrosis
  68. pulmonary hypertension
  69. pulmonary toxicity
  70. rash
  71. renal failure (unspecified)
  72. rhinitis
  73. sinus tachycardia
  74. sinusitis
  75. stomatitis
  76. teratogenesis
  77. thrombocytopenia
  78. thrombocytopenia
  79. thrombosis
  80. tumor lysis syndrome (TLS)
  81. vomiting
  82. weight loss

Monitoring Parameters

  • ejection fraction
  • pregnancy testing

Contraindications

  • angioedema
  • asthma
  • benzyl alcohol hypersensitivity
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • chemotherapy
  • chronic lung disease (CLD)
  • chronic obstructive pulmonary disease (COPD)
  • contraception requirements
  • ensure correct formulation selection
  • geriatric
  • heart failure
  • human anti-human antibody (HAHA)
  • hypertension
  • hypotension
  • infusion-related reactions
  • neutropenia
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • pulmonary disease
  • pulmonary fibrosis
  • pulmonary toxicity
  • reproductive risk
  • respiratory distress syndrome
  • tumor lysis syndrome (TLS)
  • ventricular dysfunction

Interactions

  • Anthracyclines
  • Daunorubicin
  • Doxorubicin
  • Epirubicin
  • Idarubicin
  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD
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