Travoprost

What is Travoprost

Travoprost, a synthetic analog of prostaglandin F2alpha, is a prodrug used to treat elevated intraocular pressure (IOP). The active component, travoprost free acid, is a selective FP prostanoid receptor agonist.

Travoprost is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

When studied as add-on therapy in patients being treated with timolol 0.5% twice daily, travoprost produced additional IOP reductions of 6—7 mmHg from mean baseline IOP pressures of 24—26 mmHg. In subgroup analyses of pre-marketing trials, the mean IOP reduction in black patients was up to 1.8 mmHg greater than in non-black patients; it is unknown whether this difference is due to race or to the presence of heavily pigmented tissues.

As with other ophthalmic prostaglandin analogs (e.g., latanoprost, bimatoprost), travoprost use has been associated with changes to pigmented tissues, including increased pigmentation and growth of eyelashes, and increased pigmentation of the iris and periorbital tissue.

Changes in pigmentation may be permanent. The FDA approved travoprost (Travatan) on March 16, 2001.

In September, 2006, the FDA approved Travatan Z; a formulation of travoprost preserved with sofZia, an ionic buffered system. SofZia is used as a less irritating alternative to the preservative benzalkonium chloride.

Brand Name

Travatan

Indications

  • glaucoma
  • ocular hypertension

For the reduction of elevated intraocular pressure (IOP) in patients with open angle glaucoma or ocular hypertension

Side Effects

  1. angina
  2. anxiety
  3. arrhythmia exacerbation
  4. back pain
  5. blepharitis
  6. blurred vision
  7. bradycardia
  8. cataracts
  9. chest pain (unspecified)
  10. conjunctival hyperemia
  11. conjunctivitis
  12. depression
  13. dyspepsia
  14. epistaxis
  15. foreign body sensation
  16. headache
  17. hypercholesterolemia
  18. hypertension
  19. hypertrichosis
  20. hypotension
  21. infection
  22. insomnia
  23. iridal discoloration
  24. iritis
  25. keratitis
  26. lacrimation
  27. ocular hemorrhage
  28. ocular irritation
  29. ocular pain
  30. ocular pruritus
  31. photophobia
  32. sinus tachycardia
  33. sinusitis
  34. urinary incontinence
  35. visual impairment
  36. vomiting
  37. xerophthalmia

Monitoring Parameters

  • intraocular pressure
  • ophthalmologic exam

Contraindications

  • aphakia
  • breast-feeding
  • children
  • closed-angle glaucoma
  • contact lenses
  • corneal abrasion
  • infants
  • iritis
  • keratitis
  • neonates
  • ocular infection
  • ocular surgery
  • ocular trauma
  • pregnancy
  • sunlight (UV) exposure
  • uveitis

Interactions

There are no drug interactions associated with Travoprost products.

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