What is Travoprost
Travoprost, a synthetic analog of prostaglandin F2alpha, is a prodrug used to treat elevated intraocular pressure (IOP). The active component, travoprost free acid, is a selective FP prostanoid receptor agonist.
Travoprost is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
When studied as add-on therapy in patients being treated with timolol 0.5% twice daily, travoprost produced additional IOP reductions of 6—7 mmHg from mean baseline IOP pressures of 24—26 mmHg. In subgroup analyses of pre-marketing trials, the mean IOP reduction in black patients was up to 1.8 mmHg greater than in non-black patients; it is unknown whether this difference is due to race or to the presence of heavily pigmented tissues.
As with other ophthalmic prostaglandin analogs (e.g., latanoprost, bimatoprost), travoprost use has been associated with changes to pigmented tissues, including increased pigmentation and growth of eyelashes, and increased pigmentation of the iris and periorbital tissue.
Changes in pigmentation may be permanent. The FDA approved travoprost (Travatan) on March 16, 2001.
In September, 2006, the FDA approved Travatan Z; a formulation of travoprost preserved with sofZia, an ionic buffered system. SofZia is used as a less irritating alternative to the preservative benzalkonium chloride.
Brand Name
Travatan
Indications
- glaucoma
- ocular hypertension
For the reduction of elevated intraocular pressure (IOP) in patients with open angle glaucoma or ocular hypertension
Side Effects
- angina
- anxiety
- arrhythmia exacerbation
- back pain
- blepharitis
- blurred vision
- bradycardia
- cataracts
- chest pain (unspecified)
- conjunctival hyperemia
- conjunctivitis
- depression
- dyspepsia
- epistaxis
- foreign body sensation
- headache
- hypercholesterolemia
- hypertension
- hypertrichosis
- hypotension
- infection
- insomnia
- iridal discoloration
- iritis
- keratitis
- lacrimation
- ocular hemorrhage
- ocular irritation
- ocular pain
- ocular pruritus
- photophobia
- sinus tachycardia
- sinusitis
- urinary incontinence
- visual impairment
- vomiting
- xerophthalmia
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- aphakia
- breast-feeding
- children
- closed-angle glaucoma
- contact lenses
- corneal abrasion
- infants
- iritis
- keratitis
- neonates
- ocular infection
- ocular surgery
- ocular trauma
- pregnancy
- sunlight (UV) exposure
- uveitis
Interactions
There are no drug interactions associated with Travoprost products.
