Rituximab and Hyaluronidase

What is Rituximab and Hyaluronidase medicine combination

Rituximab and hyaluronidase is a subcutaneously administered rituximab product for the treatment of adults with follicular lymphoma, diffuse B-cell lymphoma, and chronic lymphocytic leukemia.

It is used as a single agent or in combination with other chemotherapy drugs.

Rituximab is a chimeric murine/human monoclonal IgG1 kappa antibody that binds to the antigen CD20 on the surface of certain types of B-cells.

Recombinant human hyaluronidase is an endoglycosidase that is used to increase the dispersion and absorption of other drugs when administered subcutaneously.

All patients must have received at least 1 full dose of an IV infusion rituximab product without experiencing a severe adverse reaction prior to receiving rituximab/hyaluronidase.

Severe mucocutaneous reactions, hepatitis B virus reactivation, and progressive multifocal leukoencephalopathy may occur with rituximab; hyaluronidase.

Brand Name

Rituxan Hycela

Indications

  • chronic lymphocytic leukemia (CLL)
  • non-Hodgkin’s lymphoma (NHL)

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. alopecia
  4. alopecia
  5. anaphylactoid reactions
  6. anemia
  7. anemia
  8. angioedema
  9. anorexia
  10. anorexia
  11. antibody formation
  12. arthralgia
  13. arthralgia
  14. asthenia
  15. asthenia
  16. back pain
  17. back pain
  18. bone pain
  19. bone pain
  20. bronchiolitis obliterans
  21. bronchospasm
  22. cardiac arrest
  23. chest pain (unspecified)
  24. chest pain (unspecified)
  25. chills
  26. conjunctivitis
  27. constipation
  28. constipation
  29. cough
  30. cough
  31. cytokine release syndrome
  32. diarrhea
  33. diarrhea
  34. dizziness
  35. dyspepsia
  36. dyspnea
  37. dyspnea
  38. erythema
  39. fatigue
  40. fatigue
  41. fever
  42. fever
  43. flushing
  44. GI perforation
  45. headache
  46. heart failure
  47. hepatic failure
  48. hepatitis
  49. hepatitis B exacerbation
  50. hypertension
  51. hypertension
  52. hypotension
  53. hypoxia
  54. infection
  55. infection
  56. influenza
  57. injection site reaction
  58. injection site reaction
  59. insomnia
  60. insomnia
  61. leukopenia
  62. leukopenia
  63. lupus-like symptoms
  64. muscle cramps
  65. myalgia
  66. myocardial infarction
  67. nausea
  68. nausea
  69. nephrotoxicity
  70. neutropenia
  71. neutropenia
  72. oliguria
  73. optic neuritis
  74. pancytopenia
  75. paresthesias
  76. paresthesias
  77. pemphigus
  78. peripheral edema
  79. peripheral edema
  80. peripheral neuropathy
  81. peripheral neuropathy
  82. pharyngitis
  83. progressive multifocal leukoencephalopathy
  84. pruritus
  85. rash
  86. renal failure (unspecified)
  87. serum sickness
  88. sinusitis
  89. sinusitis
  90. Stevens-Johnson syndrome
  91. stomatitis
  92. stomatitis
  93. throat irritation
  94. thrombocytopenia
  95. thrombocytopenia
  96. toxic epidermal necrolysis
  97. tumor lysis syndrome (TLS)
  98. urticaria
  99. uveitis
  100. vasculitis
  101. ventricular fibrillation
  102. vomiting
  103. vomiting

Monitoring Parameters

  • CBC with differential
  • hepatitis B serology
  • pregnancy testing
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid

Contraindications

  • anemia
  • angina
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • contraception requirements
  • cytokine release syndrome
  • fungal infection
  • GI obstruction
  • GI perforation
  • hepatitis B exacerbation
  • infection
  • neutropenia
  • pregnancy
  • pregnancy testing
  • progressive multifocal leukoencephalopathy
  • pulmonary disease
  • renal disease
  • renal impairment
  • reproductive risk
  • serious rash
  • thrombocytopenia
  • tumor lysis syndrome (TLS)
  • vaccination
  • viral infection

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Adalimumab
  • Amide local anesthetics
  • Aminosalicylate sodium, Aminosalicylic acid
  • Anakinra
  • Antithymocyte Globulin
  • Articaine; Epinephrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Azathioprine
  • Azelastine; Fluticasone
  • Baricitinib
  • Beclomethasone
  • Belimumab
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betamethasone
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Certolizumab pegol
  • Chloroprocaine
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Cisplatin
  • Cocaine
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Cyclophosphamide
  • Deflazacort
  • Dexamethasone
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Echinacea
  • Elagolix; Estradiol; Norethindrone acetate
  • Ester local anesthetics
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Etanercept
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Gold
  • Golimumab
  • Hydrocortisone
  • Hydroxychloroquine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Infliximab
  • Leflunomide
  • Levobupivacaine
  • Lidocaine
  • Lidocaine; Prilocaine
  • Live Vaccines
  • Magnesium Salicylate
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Methotrexate
  • Methylprednisolone
  • Mometasone
  • Natalizumab
  • Ocrelizumab
  • Palifermin
  • Penicillamine
  • Prednisolone
  • Prednisone
  • Prilocaine
  • Prilocaine; Epinephrine
  • Procaine
  • Ropivacaine
  • Salicylates
  • Salsalate
  • Sarilumab
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Sipuleucel-T
  • Sulfasalazine
  • Tetracaine
  • Tocilizumab
  • Tofacitinib
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Upadacitinib
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