What's on this Page
What is Rituximab and Hyaluronidase medicine combination
Rituximab and hyaluronidase is a subcutaneously administered rituximab product for the treatment of adults with follicular lymphoma, diffuse B-cell lymphoma, and chronic lymphocytic leukemia.
It is used as a single agent or in combination with other chemotherapy drugs.
Rituximab is a chimeric murine/human monoclonal IgG1 kappa antibody that binds to the antigen CD20 on the surface of certain types of B-cells.
Recombinant human hyaluronidase is an endoglycosidase that is used to increase the dispersion and absorption of other drugs when administered subcutaneously.
All patients must have received at least 1 full dose of an IV infusion rituximab product without experiencing a severe adverse reaction prior to receiving rituximab/hyaluronidase.
Severe mucocutaneous reactions, hepatitis B virus reactivation, and progressive multifocal leukoencephalopathy may occur with rituximab; hyaluronidase.
Brand Name
Rituxan Hycela
Indications
- chronic lymphocytic leukemia (CLL)
- non-Hodgkin’s lymphoma (NHL)
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- alopecia
- anaphylactoid reactions
- anemia
- anemia
- angioedema
- anorexia
- anorexia
- antibody formation
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- bone pain
- bone pain
- bronchiolitis obliterans
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- chest pain (unspecified)
- chills
- conjunctivitis
- constipation
- constipation
- cough
- cough
- cytokine release syndrome
- diarrhea
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- dyspnea
- erythema
- fatigue
- fatigue
- fever
- fever
- flushing
- GI perforation
- headache
- heart failure
- hepatic failure
- hepatitis
- hepatitis B exacerbation
- hypertension
- hypertension
- hypotension
- hypoxia
- infection
- infection
- influenza
- injection site reaction
- injection site reaction
- insomnia
- insomnia
- leukopenia
- leukopenia
- lupus-like symptoms
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- nausea
- nephrotoxicity
- neutropenia
- neutropenia
- oliguria
- optic neuritis
- pancytopenia
- paresthesias
- paresthesias
- pemphigus
- peripheral edema
- peripheral edema
- peripheral neuropathy
- peripheral neuropathy
- pharyngitis
- progressive multifocal leukoencephalopathy
- pruritus
- rash
- renal failure (unspecified)
- serum sickness
- sinusitis
- sinusitis
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- throat irritation
- thrombocytopenia
- thrombocytopenia
- toxic epidermal necrolysis
- tumor lysis syndrome (TLS)
- urticaria
- uveitis
- vasculitis
- ventricular fibrillation
- vomiting
- vomiting
Monitoring Parameters
- CBC with differential
- hepatitis B serology
- pregnancy testing
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- anemia
- angina
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- contraception requirements
- cytokine release syndrome
- fungal infection
- GI obstruction
- GI perforation
- hepatitis B exacerbation
- infection
- neutropenia
- pregnancy
- pregnancy testing
- progressive multifocal leukoencephalopathy
- pulmonary disease
- renal disease
- renal impairment
- reproductive risk
- serious rash
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vaccination
- viral infection
Interactions
- Abatacept
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Adalimumab
- Amide local anesthetics
- Aminosalicylate sodium, Aminosalicylic acid
- Anakinra
- Antithymocyte Globulin
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azathioprine
- Azelastine; Fluticasone
- Baricitinib
- Beclomethasone
- Belimumab
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Betamethasone
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Certolizumab pegol
- Chloroprocaine
- Choline Salicylate; Magnesium Salicylate
- Ciclesonide
- Cisplatin
- Cocaine
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Cyclophosphamide
- Deflazacort
- Dexamethasone
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Echinacea
- Elagolix; Estradiol; Norethindrone acetate
- Ester local anesthetics
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Etanercept
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Gold
- Golimumab
- Hydrocortisone
- Hydroxychloroquine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Infliximab
- Leflunomide
- Levobupivacaine
- Lidocaine
- Lidocaine; Prilocaine
- Live Vaccines
- Magnesium Salicylate
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Methotrexate
- Methylprednisolone
- Mometasone
- Natalizumab
- Ocrelizumab
- Palifermin
- Penicillamine
- Prednisolone
- Prednisone
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Ropivacaine
- Salicylates
- Salsalate
- Sarilumab
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Sipuleucel-T
- Sulfasalazine
- Tetracaine
- Tocilizumab
- Tofacitinib
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Upadacitinib