What is Ticarcillin
Ticarcillin is a parenteral, semisynthetic, extended-spectrum carboxypenicillin. Extended-spectrum penicillins are used mainly in the treatment of infections suspected or known to be caused by gram-negative bacteria and in combination with an aminoglycoside to treat systemic Pseudomonas infections.
Intravenous ticarcillin has replaced IV carbenicillin, which has a similar spectrum of activity but is less potent.
Ticarcillin is used in the treatment of intra-abdominal infections, respiratory and urinary tract infections, skin and soft-tissue infections, and other infections caused by susceptible organisms.
Ticarcillin was approved by the FDA in 1976.
Brand Name
Ticar
Indications
- Acinetobacter sp.
- Actinomyces sp.
- Bacillus anthracis
- bacteremia
- Bacteroides fragilis
- Bacteroides sp.
- Bifidobacterium sp.
- cellulitis
- Citrobacter sp.
- Clostridium perfringens
- Clostridium sp.
- diabetic foot ulcer
- Eikenella corrodens
- endometritis
- Enterobacter sp.
- Escherichia coli
- Eubacterium sp.
- Fusobacterium sp.
- Haemophilus influenzae (beta-lactamase negative)
- intraabdominal abscess
- intraabdominal infections
- Lactobacillus sp.
- lower respiratory tract infections
- lung abscess
- Moraxella sp.
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Pasteurella multocida
- pelvic abscess
- pelvic inflammatory disease (PID)
- Peptococcus sp.
- Peptostreptococcus sp.
- peritonitis
- pleural empyema
- Prevotella melaninogenica
- Propionibacterium sp.
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Pseudomonas aeruginosa
- Pseudomonas sp.
- Salmonella sp.
- sepsis
- Serratia sp.
- Shigella sp.
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Stenotrophomonas maltophilia
- Streptococcus agalactiae (group B streptococci)
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- urinary tract infection (UTI)
- Veillonella sp.
- Viridans streptococci
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- arthralgia
- bleeding
- bullous rash
- chills
- diarrhea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- erythema nodosum
- exfoliative dermatitis
- fever
- hypokalemia
- leukopenia
- maculopapular rash
- malaise
- myalgia
- nausea
- neutropenia
- phlebitis
- platelet dysfunction
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- purpura
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- thrombosis
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- cystic fibrosis
- diabetes mellitus
- diarrhea
- eczema
- electrolyte imbalance
- geriatric
- GI disease
- heart failure
- hemophilia
- hypokalemia
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- sexually transmitted disease
- sodium restriction
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Betrixaban
- Bivalirudin
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Edoxaban
- Elagolix; Estradiol; Norethindrone acetate
- Enoxaparin
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Fondaparinux
- Furosemide
- Heparin
- Indomethacin
- Lepirudin
- Leuprolide; Norethindrone
- Levonorgestrel
- Magnesium Salicylate
- Mestranol; Norethindrone
- Methotrexate
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Pentosan
- Probenecid
- Rivaroxaban
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tetracyclines
- Tinzaparin
- Typhoid Vaccine
- Warfarin
