Tranylcypromine

What is Tranylcypromine

Tranylcypromine is an oral antidepressant of the monoamine oxidase inhibitor (MAOI) class.

Due to the dietary restrictions required for MAOI use, as well as their side effect profile and the potential for serious drug-drug and drug-food interactions, MAOIs are primarily considered an option for major depressive disorder (MDD) that is refractory to treatment with other antidepressants.

MAOIs are used to treat major depression in patients who have not responded to other antidepressant therapy and are either closely supervised or hospitalized.

MAOIs may be particularly effective for MDD with atypical features, and are recommended in some treatment guidelines for refractory cases of anxiety disorders such as social anxiety disorder and panic disorder. Tranylcypromine was approved by the FDA in 1961.

Brand Name

Parnate

Side Effects

1. abdominal pain
2. acne vulgaris
3. agitation
4. agranulocytosis
5. akinesia
6. alopecia
7. anemia
8. anorexia
9. anxiety
10. appetite stimulation
11. ataxia
12. blurred vision
13. chills
14. confusion
15. constipation
16. depression
17. diarrhea
18. dizziness
19. drowsiness
20. dysarthria
21. ejaculation dysfunction
22. elevated hepatic enzymes
23. headache
24. hepatitis
25. hypertension
26. hypertensive crisis
27. hyperthyroidism
28. hypoglycemia
29. impotence (erectile dysfunction)
30. increased urinary frequency
31. insomnia
32. intracranial bleeding
33. jaundice
34. leukopenia
35. mania
36. memory impairment
37. myoclonia
38. nausea
39. orgasm dysfunction
40. orthostatic hypotension
41. palpitations
42. paresthesias
43. peripheral edema
44. pseudoparkinsonism
45. rash
46. restlessness
47. seizures
48. serotonin syndrome
49. SIADH
50. sinus tachycardia
51. suicidal ideation
52. syncope
53. thrombocytopenia
54. tinnitus
55. tremor
56. urinary incontinence
57. urinary retention
58. urticaria
59. vitamin B6 deficiency
60. weakness
61. weight gain
62. withdrawal
63. xerostomia

Monitoring Parameters

• blood pressure
• heart rate
• LFTs
• serum creatinine/BUN

Contraindications

• abrupt discontinuation
• acute myocardial infarction
• alcoholism
• angina
• anticholinergic medications
• anxiety
• asthma
• bipolar disorder
• breast-feeding
• bronchitis
• cardiac disease
• cerebrovascular disease
• children
• coadministration with other CNS depressants
• dental work
• diabetes mellitus
• driving or operating machinery
• ethanol ingestion
• geriatric
• head trauma
• headache
• hepatic disease
• hepatitis
• hypertension
• hypertensive crisis
• hyperthyroidism
• increased intracranial pressure
• intracranial bleeding
• mania
• MAOI therapy
• pheochromocytoma
• pregnancy
• psychosis
• radiographic contrast administration
• schizophrenia
• seizure disorder
• seizures
• spinal anesthesia
• stroke
• substance abuse
• suicidal ideation
• surgery

Tranylcypromine is contraindicated in patients with known hypersensitivity to tranylcypromine.

Interactions

• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Almotriptan
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Alprazolam
• Altretamine
• Ambrisentan
• Amide local anesthetics
• Amifampridine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anxiolytics; Sedatives; and Hypnotics
• Apraclonidine
• Armodafinil
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atenolol
• Atenolol; Chlorthalidone
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• atypical antipsychotic
• Azilsartan
• Azilsartan; Chlorthalidone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzonatate
• Beta-agonists
• Beta-blockers
• Betaxolol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bretylium
• Brimonidine
• Brimonidine; Brinzolamide
• Brimonidine; Timolol
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carteolol
• Carvedilol
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone; Clonidine
• Clevidipine
• Clomipramine
• Clonazepam
• Clonidine
• Clorazepate
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Cyclobenzaprine
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Desflurane
• Desipramine
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Diazoxide
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Diphenhydramine; Hydrocodone; Phenylephrine
• Disulfiram
• Dolasetron
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Dronabinol
• Droperidol
• Droxidopa
• Duloxetine
• Eletriptan
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esketamine
• Eslicarbazepine
• Esmolol
• Estazolam
• Ester local anesthetics
• Ethanol
• Etomidate
• Felbamate
• Felodipine
• Fenoldopam
• Fentanyl
• Fluphenazine
• Flurazepam
• food
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Frovatriptan
• Gabapentin
• Gallium Ga 68 Dotatate
• General anesthetics
• Ginseng, Panax ginseng
• Glipizide; Metformin
• Glyburide; Metformin
• Granisetron
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanabenz
• Guanfacine
• Halothane
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Iloprost
• Imipramine
• Incretin Mimetics
• Indapamide
• Insulins
• Iobenguane I 131
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Irbesartan
• Isoflurane
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Isradipine
• Ketamine
• Labetalol
• Lamotrigine
• Lasmiditan
• Lemborexant
• Levetiracetam
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levodopa
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Lisinopril
• Lithium
• Loop diuretics
• Lorazepam
• Lorcaserin
• Losartan
• Loxapine
• Magnesium Salts
• Mannitol
• Maprotiline
• Meglitinides
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Mesoridazine
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methazolamide
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methyldopa
• Methylene Blue
• Metoclopramide
• Metoprolol
• Midazolam
• Milnacipran
• Minoxidil
• Mirabegron
• Mirtazapine
• Modafinil
• Moexipril
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nalbuphine
• Naproxen; Sumatriptan
• Naratriptan
• Nateglinide
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Netupitant, Fosnetupitant; Palonosetron
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Nortriptyline
• Olmesartan
• Ondansetron
• Oxazepam
• Oxcarbazepine
• Oxycodone
• Oxymetazoline
• Oxymorphone
• Ozanimod
• Palonosetron
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phenoxybenzamine
• Phentolamine
• Phenylephrine; Promethazine
• Pindolol
• Potassium-sparing diuretics
• Pramlintide
• Prazosin
• Pregabalin
• Primidone
• Procaine
• Procarbazine
• Prochlorperazine
• Promethazine
• Propofol
• Propoxyphene
• Propranolol
• Protriptyline
• Quazepam
• Quinapril
• Ramelteon
• Ramipril
• Rasagiline
• Remifentanil
• Repaglinide
• Reserpine
• Rizatriptan
• Sacubitril; Valsartan
• Safinamide
• Saxagliptin
• Secobarbital
• Sedating H1-blockers
• Selective norepinephrine reuptake inhibitors
• Selective serotonin reuptake inhibitors
• Serotonin norepinephrine reuptake inhibitors
• Sevoflurane
• Sibutramine
• Sildenafil
• Simvastatin; Sitagliptin
• Sitagliptin
• Sodium Oxybate
• Solriamfetol
• Sotalol
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Succinimides
• Sufentanil
• Sulfonylureas
• Sumatriptan
• Sympathomimetics
• Tapentadol
• Tedizolid
• Telmisartan
• Temazepam
• Terazosin
• Tetrabenazine
• Tetracaine
• Tetrahydrozoline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Tiagabine
• Timolol
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Trazodone
• Treprostinil
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trimipramine
• Valbenazine
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Valsartan
• Vasodilators
• Venlafaxine
• Verapamil
• Vilazodone
• Vortioxetine
• Yohimbine
• Zolmitriptan
• Zonisamide