What is Tranylcypromine
Tranylcypromine is an oral antidepressant of the monoamine oxidase inhibitor (MAOI) class.
Due to the dietary restrictions required for MAOI use, as well as their side effect profile and the potential for serious drug-drug and drug-food interactions, MAOIs are primarily considered an option for major depressive disorder (MDD) that is refractory to treatment with other antidepressants.
MAOIs are used to treat major depression in patients who have not responded to other antidepressant therapy and are either closely supervised or hospitalized.
MAOIs may be particularly effective for MDD with atypical features, and are recommended in some treatment guidelines for refractory cases of anxiety disorders such as social anxiety disorder and panic disorder. Tranylcypromine was approved by the FDA in 1961.
Brand Name
Parnate
Side Effects
- abdominal pain
- acne vulgaris
- agitation
- agranulocytosis
- akinesia
- alopecia
- anemia
- anorexia
- anxiety
- appetite stimulation
- ataxia
- blurred vision
- chills
- confusion
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- dysarthria
- ejaculation dysfunction
- elevated hepatic enzymes
- headache
- hepatitis
- hypertension
- hypertensive crisis
- hyperthyroidism
- hypoglycemia
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- intracranial bleeding
- jaundice
- leukopenia
- mania
- memory impairment
- myoclonia
- nausea
- orgasm dysfunction
- orthostatic hypotension
- palpitations
- paresthesias
- peripheral edema
- pseudoparkinsonism
- rash
- restlessness
- seizures
- serotonin syndrome
- SIADH
- sinus tachycardia
- suicidal ideation
- syncope
- thrombocytopenia
- tinnitus
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vitamin B6 deficiency
- weakness
- weight gain
- withdrawal
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- LFTs
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- alcoholism
- angina
- anticholinergic medications
- anxiety
- asthma
- bipolar disorder
- breast-feeding
- bronchitis
- cardiac disease
- cerebrovascular disease
- children
- coadministration with other CNS depressants
- dental work
- diabetes mellitus
- driving or operating machinery
- ethanol ingestion
- geriatric
- head trauma
- headache
- hepatic disease
- hepatitis
- hypertension
- hypertensive crisis
- hyperthyroidism
- increased intracranial pressure
- intracranial bleeding
- mania
- MAOI therapy
- pheochromocytoma
- pregnancy
- psychosis
- radiographic contrast administration
- schizophrenia
- seizure disorder
- seizures
- spinal anesthesia
- stroke
- substance abuse
- suicidal ideation
- surgery
Tranylcypromine is contraindicated in patients with known hypersensitivity to tranylcypromine.
Interactions
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Altretamine
- Ambrisentan
- Amide local anesthetics
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anxiolytics; Sedatives; and Hypnotics
- Apraclonidine
- Armodafinil
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azilsartan
- Azilsartan; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Beta-agonists
- Beta-blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bretylium
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carteolol
- Carvedilol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Clevidipine
- Clomipramine
- Clonazepam
- Clonidine
- Clorazepate
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclobenzaprine
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desflurane
- Desipramine
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disulfiram
- Dolasetron
- Dorzolamide; Timolol
- Doxazosin
- Doxepin
- Dronabinol
- Droperidol
- Droxidopa
- Duloxetine
- Eletriptan
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esketamine
- Eslicarbazepine
- Esmolol
- Estazolam
- Ester local anesthetics
- Ethanol
- Etomidate
- Felbamate
- Felodipine
- Fenoldopam
- Fentanyl
- Fluphenazine
- Flurazepam
- food
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Frovatriptan
- Gabapentin
- Gallium Ga 68 Dotatate
- General anesthetics
- Ginseng, Panax ginseng
- Glipizide; Metformin
- Glyburide; Metformin
- Granisetron
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Guanfacine
- Halothane
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Iloprost
- Imipramine
- Incretin Mimetics
- Indapamide
- Insulins
- Iobenguane I 131
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Isradipine
- Ketamine
- Labetalol
- Lamotrigine
- Lasmiditan
- Lemborexant
- Levetiracetam
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levodopa
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Linagliptin
- Linagliptin; Metformin
- Lisinopril
- Lithium
- Loop diuretics
- Lorazepam
- Lorcaserin
- Losartan
- Loxapine
- Magnesium Salts
- Mannitol
- Maprotiline
- Meglitinides
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mesoridazine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methazolamide
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methyldopa
- Methylene Blue
- Metoclopramide
- Metoprolol
- Midazolam
- Milnacipran
- Minoxidil
- Mirabegron
- Mirtazapine
- Modafinil
- Moexipril
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nalbuphine
- Naproxen; Sumatriptan
- Naratriptan
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Netupitant, Fosnetupitant; Palonosetron
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nortriptyline
- Olmesartan
- Ondansetron
- Oxazepam
- Oxcarbazepine
- Oxycodone
- Oxymetazoline
- Oxymorphone
- Ozanimod
- Palonosetron
- Penbutolol
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenoxybenzamine
- Phentolamine
- Phenylephrine; Promethazine
- Pindolol
- Potassium-sparing diuretics
- Pramlintide
- Prazosin
- Pregabalin
- Primidone
- Procaine
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Quazepam
- Quinapril
- Ramelteon
- Ramipril
- Rasagiline
- Remifentanil
- Repaglinide
- Reserpine
- Rizatriptan
- Sacubitril; Valsartan
- Safinamide
- Saxagliptin
- Secobarbital
- Sedating H1-blockers
- Selective norepinephrine reuptake inhibitors
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Sevoflurane
- Sibutramine
- Sildenafil
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Oxybate
- Solriamfetol
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Succinimides
- Sufentanil
- Sulfonylureas
- Sumatriptan
- Sympathomimetics
- Tapentadol
- Tedizolid
- Telmisartan
- Temazepam
- Terazosin
- Tetrabenazine
- Tetracaine
- Tetrahydrozoline
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Tiagabine
- Timolol
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Trazodone
- Treprostinil
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Valbenazine
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vasodilators
- Venlafaxine
- Verapamil
- Vilazodone
- Vortioxetine
- Yohimbine
- Zolmitriptan
- Zonisamide