Tranylcypromine

What is Tranylcypromine

Tranylcypromine is an oral antidepressant of the monoamine oxidase inhibitor (MAOI) class.

Due to the dietary restrictions required for MAOI use, as well as their side effect profile and the potential for serious drug-drug and drug-food interactions, MAOIs are primarily considered an option for major depressive disorder (MDD) that is refractory to treatment with other antidepressants.

MAOIs are used to treat major depression in patients who have not responded to other antidepressant therapy and are either closely supervised or hospitalized.

MAOIs may be particularly effective for MDD with atypical features, and are recommended in some treatment guidelines for refractory cases of anxiety disorders such as social anxiety disorder and panic disorder. Tranylcypromine was approved by the FDA in 1961.

Brand Name

Parnate

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. agitation
  4. agranulocytosis
  5. akinesia
  6. alopecia
  7. anemia
  8. anorexia
  9. anxiety
  10. appetite stimulation
  11. ataxia
  12. blurred vision
  13. chills
  14. confusion
  15. constipation
  16. depression
  17. diarrhea
  18. dizziness
  19. drowsiness
  20. dysarthria
  21. ejaculation dysfunction
  22. elevated hepatic enzymes
  23. headache
  24. hepatitis
  25. hypertension
  26. hypertensive crisis
  27. hyperthyroidism
  28. hypoglycemia
  29. impotence (erectile dysfunction)
  30. increased urinary frequency
  31. insomnia
  32. intracranial bleeding
  33. jaundice
  34. leukopenia
  35. mania
  36. memory impairment
  37. myoclonia
  38. nausea
  39. orgasm dysfunction
  40. orthostatic hypotension
  41. palpitations
  42. paresthesias
  43. peripheral edema
  44. pseudoparkinsonism
  45. rash
  46. restlessness
  47. seizures
  48. serotonin syndrome
  49. SIADH
  50. sinus tachycardia
  51. suicidal ideation
  52. syncope
  53. thrombocytopenia
  54. tinnitus
  55. tremor
  56. urinary incontinence
  57. urinary retention
  58. urticaria
  59. vitamin B6 deficiency
  60. weakness
  61. weight gain
  62. withdrawal
  63. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate
  • LFTs
  • serum creatinine/BUN

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • alcoholism
  • angina
  • anticholinergic medications
  • anxiety
  • asthma
  • bipolar disorder
  • breast-feeding
  • bronchitis
  • cardiac disease
  • cerebrovascular disease
  • children
  • coadministration with other CNS depressants
  • dental work
  • diabetes mellitus
  • driving or operating machinery
  • ethanol ingestion
  • geriatric
  • head trauma
  • headache
  • hepatic disease
  • hepatitis
  • hypertension
  • hypertensive crisis
  • hyperthyroidism
  • increased intracranial pressure
  • intracranial bleeding
  • mania
  • MAOI therapy
  • pheochromocytoma
  • pregnancy
  • psychosis
  • radiographic contrast administration
  • schizophrenia
  • seizure disorder
  • seizures
  • spinal anesthesia
  • stroke
  • substance abuse
  • suicidal ideation
  • surgery

Tranylcypromine is contraindicated in patients with known hypersensitivity to tranylcypromine.

Interactions

  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Altretamine
  • Ambrisentan
  • Amide local anesthetics
  • Amifampridine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anxiolytics; Sedatives; and Hypnotics
  • Apraclonidine
  • Armodafinil
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzonatate
  • Beta-agonists
  • Beta-blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bretylium
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroprocaine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Clevidipine
  • Clomipramine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desflurane
  • Desipramine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diazoxide
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disulfiram
  • Dolasetron
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxepin
  • Dronabinol
  • Droperidol
  • Droxidopa
  • Duloxetine
  • Eletriptan
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esketamine
  • Eslicarbazepine
  • Esmolol
  • Estazolam
  • Ester local anesthetics
  • Ethanol
  • Etomidate
  • Felbamate
  • Felodipine
  • Fenoldopam
  • Fentanyl
  • Fluphenazine
  • Flurazepam
  • food
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Frovatriptan
  • Gabapentin
  • Gallium Ga 68 Dotatate
  • General anesthetics
  • Ginseng, Panax ginseng
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Granisetron
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Halothane
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Iloprost
  • Imipramine
  • Incretin Mimetics
  • Indapamide
  • Insulins
  • Iobenguane I 131
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Irbesartan
  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isosulfan Blue
  • Isradipine
  • Ketamine
  • Labetalol
  • Lamotrigine
  • Lasmiditan
  • Lemborexant
  • Levetiracetam
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levodopa
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Linagliptin
  • Linagliptin; Metformin
  • Lisinopril
  • Lithium
  • Loop diuretics
  • Lorazepam
  • Lorcaserin
  • Losartan
  • Loxapine
  • Magnesium Salts
  • Mannitol
  • Maprotiline
  • Meglitinides
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Mesoridazine
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyldopa
  • Methylene Blue
  • Metoclopramide
  • Metoprolol
  • Midazolam
  • Milnacipran
  • Minoxidil
  • Mirabegron
  • Mirtazapine
  • Modafinil
  • Moexipril
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nalbuphine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nateglinide
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Netupitant, Fosnetupitant; Palonosetron
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitroglycerin
  • Nitroprusside
  • Non-Ionic Contrast Media
  • Nortriptyline
  • Olmesartan
  • Ondansetron
  • Oxazepam
  • Oxcarbazepine
  • Oxycodone
  • Oxymetazoline
  • Oxymorphone
  • Ozanimod
  • Palonosetron
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine; Promethazine
  • Pindolol
  • Potassium-sparing diuretics
  • Pramlintide
  • Prazosin
  • Pregabalin
  • Primidone
  • Procaine
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Quazepam
  • Quinapril
  • Ramelteon
  • Ramipril
  • Rasagiline
  • Remifentanil
  • Repaglinide
  • Reserpine
  • Rizatriptan
  • Sacubitril; Valsartan
  • Safinamide
  • Saxagliptin
  • Secobarbital
  • Sedating H1-blockers
  • Selective norepinephrine reuptake inhibitors
  • Selective serotonin reuptake inhibitors
  • Serotonin norepinephrine reuptake inhibitors
  • Sevoflurane
  • Sibutramine
  • Sildenafil
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium Oxybate
  • Solriamfetol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Succinimides
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Sympathomimetics
  • Tapentadol
  • Tedizolid
  • Telmisartan
  • Temazepam
  • Terazosin
  • Tetrabenazine
  • Tetracaine
  • Tetrahydrozoline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tiagabine
  • Timolol
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
  • Valbenazine
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vasodilators
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vortioxetine
  • Yohimbine
  • Zolmitriptan
  • Zonisamide
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