What is Tranexamic Acid
Tranexamic acid is an oral and injectable antifibrinolytic agent indicated for short-term use to reduce or prevent hemorrhage and reduce the need for replacement therapy during and after tooth extraction in patients with hemophilia and for the treatment of cyclic heavy menstrual bleeding.
Tranexamic acid may increase the risk of thromboembolic events. Venous and arterial thrombosis or thromboembolism have been reported in patients treated with tranexamic acid.
Tranexamic acid is contraindicated in patients with active thromboembolic disease or a history or intrinsic risk of thrombosis or thromboembolism.
Tranexamic acid has actions similar to those of aminocaproic acid, but it is approximately 10 times more potent.
Brand Name
- Cyklokapron
- Lysteda
Indications
- angioedema prophylaxis
- bleeding prophylaxis
- epistaxis
- hemophilia A
- hemophilia B
- hyphema
- intracranial rebleeding prophylaxis
- menorrhagia
- subarachnoid hemorrhage
- surgical bleeding prophylaxis
For bleeding prophylaxis, including after ocular trauma (hyphema)†
for short-term use to reduce or prevent hemorrhage and reduce the need for replacement therapy during and after tooth extraction in hemophilia A and hemophilia B patients
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- anemia
- arthralgia
- back pain
- diarrhea
- dizziness
- dyschromatopsia
- dyspnea
- fatigue
- flushing
- headache
- hypotension
- migraine
- muscle cramps
- musculoskeletal pain
- myalgia
- nasal congestion
- nausea
- pulmonary embolism
- rash
- retinal thrombosis
- seizures
- sinusitis
- thromboembolism
- thrombosis
- visual impairment
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- driving or operating machinery
- geriatric
- intracranial bleeding
- pregnancy
- renal impairment
- seizure disorder
- surgery
- thromboembolic disease
- thrombosis
- visual disturbance
Interactions
- Alteplase
- Anti-inhibitor Coagulant Complex
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Chlorpromazine
- Ciclesonide
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Deflazacort
- Dexamethasone
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Factor IX
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Hydrocortisone
- Lithium
- Mestranol; Norethindrone
- Methylprednisolone
- Mometasone
- Prednisolone
- Prednisone
- Prothrombin Complex Concentrate, Human
- Reteplase, r-PA
- Segesterone Acetate; Ethinyl Estradiol
- Streptokinase
- Tenecteplase
- Thrombolytic Agents
- Tolvaptan
- Tretinoin, ATRA
- Triamcinolone
- Urokinase
