Tranexamic Acid

What is Tranexamic Acid

Tranexamic acid is an oral and injectable antifibrinolytic agent indicated for short-term use to reduce or prevent hemorrhage and reduce the need for replacement therapy during and after tooth extraction in patients with hemophilia and for the treatment of cyclic heavy menstrual bleeding.

Tranexamic acid may increase the risk of thromboembolic events. Venous and arterial thrombosis or thromboembolism have been reported in patients treated with tranexamic acid.

Tranexamic acid is contraindicated in patients with active thromboembolic disease or a history or intrinsic risk of thrombosis or thromboembolism.

Tranexamic acid has actions similar to those of aminocaproic acid, but it is approximately 10 times more potent.

Brand Name

  • Cyklokapron
  • Lysteda

Indications

  • angioedema prophylaxis
  • bleeding prophylaxis
  • epistaxis
  • hemophilia A
  • hemophilia B
  • hyphema
  • intracranial rebleeding prophylaxis
  • menorrhagia
  • subarachnoid hemorrhage
  • surgical bleeding prophylaxis

For bleeding prophylaxis, including after ocular trauma (hyphema)†

for short-term use to reduce or prevent hemorrhage and reduce the need for replacement therapy during and after tooth extraction in hemophilia A and hemophilia B patients

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. anemia
  5. arthralgia
  6. back pain
  7. diarrhea
  8. dizziness
  9. dyschromatopsia
  10. dyspnea
  11. fatigue
  12. flushing
  13. headache
  14. hypotension
  15. migraine
  16. muscle cramps
  17. musculoskeletal pain
  18. myalgia
  19. nasal congestion
  20. nausea
  21. pulmonary embolism
  22. rash
  23. retinal thrombosis
  24. seizures
  25. sinusitis
  26. thromboembolism
  27. thrombosis
  28. visual impairment
  29. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • driving or operating machinery
  • geriatric
  • intracranial bleeding
  • pregnancy
  • renal impairment
  • seizure disorder
  • surgery
  • thromboembolic disease
  • thrombosis
  • visual disturbance

Interactions

  • Alteplase
  • Anti-inhibitor Coagulant Complex
  • Azelastine; Fluticasone
  • Beclomethasone
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Chlorpromazine
  • Ciclesonide
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Deflazacort
  • Dexamethasone
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Factor IX
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Hydrocortisone
  • Lithium
  • Mestranol; Norethindrone
  • Methylprednisolone
  • Mometasone
  • Prednisolone
  • Prednisone
  • Prothrombin Complex Concentrate, Human
  • Reteplase, r-PA
  • Segesterone Acetate; Ethinyl Estradiol
  • Streptokinase
  • Tenecteplase
  • Thrombolytic Agents
  • Tolvaptan
  • Tretinoin, ATRA
  • Triamcinolone
  • Urokinase
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top