What is Thiothixene
Thiothixene is an antipsychotic drug that is structurally similar to trifluoperazine and shares some of the pharmacological properties of the high-potency antipsychotics.
It is used in the treatment of psychotic disorders and schizophrenia.
Five milligrams of thiothixene is equivalent to 100 mg of chlorpromazine, the prototype antipsychotic. Thiothixene was approved by the FDA in 1967.
Brand Name
Navane
Indications
- behavioral or psychological symptoms of dementia
- schizophrenia
Side Effects
- agitation
- agranulocytosis
- akathisia
- amenorrhea
- anorexia
- aplastic anemia
- appetite stimulation
- asphyxia
- blurred vision
- breast enlargement
- cardiac arrest
- cholestasis
- constipation
- contact dermatitis
- corneal opacification
- diarrhea
- dizziness
- drowsiness
- dysphagia
- dystonic reaction
- ejaculation dysfunction
- elevated hepatic enzymes
- eosinophilia
- fatigue
- fever
- galactorrhea
- glycosuria
- gynecomastia
- hallucinations
- hemolytic anemia
- hyperglycemia
- hyperhidrosis
- hyperprolactinemia
- hypersalivation
- hyperthermia
- hypoglycemia
- hyponatremia
- hypotension
- hypothermia
- impotence (erectile dysfunction)
- infertility
- insomnia
- jaundice
- leukocytosis
- leukopenia
- libido decrease
- lupus-like symptoms
- mastalgia
- menstrual irregularity
- nasal congestion
- nausea
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- pancytopenia
- peripheral edema
- photosensitivity
- pruritus
- pseudoparkinsonism
- purpura
- QT prolongation
- rash
- restlessness
- retinopathy
- seizures
- SIADH
- sinus tachycardia
- skin hyperpigmentation
- stroke
- syncope
- tardive dyskinesia
- thrombocytopenia
- torsade de pointes
- urticaria
- visual impairment
- vomiting
- water intoxication
- weakness
- weight gain
- xerostomia
Monitoring Parameters
- CBC
- ophthalmologic exam
- serum prolactin
- thyroid function tests (TFTs)
- urinalysis
Contraindications
- agranulocytosis
- ambient temperature increase
- brain tumor
- breast cancer
- breast-feeding
- cardiac disease
- children
- CNS depression
- coadministration with other CNS depressants
- coma
- dehydration
- dementia
- driving or operating machinery
- dysphagia
- ethanol ingestion
- geriatric
- glaucoma
- hematological disease
- hepatic disease
- hyperthermia
- hypocalcemia
- hypotension
- hypothermia
- infants
- leukopenia
- neonates
- neurological disease
- neutropenia
- orthostatic hypotension
- Parkinson’s disease
- pregnancy
- pregnancy testing
- prostatic hypertrophy
- Reye’s syndrome
- seizure disorder
- strenuous exercise
- stroke
- syncope
- tardive dyskinesia
- thyroid disease
- tobacco smoking
- urinary retention
Interactions
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alpha-blockers
- Amantadine
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine; Dextroamphetamine Salts
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzphetamine
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium-channel blockers
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capsaicin; Metaxalone
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Carteolol
- Carvedilol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Charcoal
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorcyclizine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Clemastine
- Clevidipine
- Clobazam
- Clomipramine
- Clonidine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Degarelix
- Desipramine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Promethazine
- Diazoxide
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dopamine
- dopamine agonists
- Doxepin
- Doxorubicin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Eliglustat
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Ephedrine
- Epinephrine
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esketamine
- Esmolol
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethosuximide
- Etomidate
- Felodipine
- Fenoldopam
- Fentanyl
- Fluoxetine; Olanzapine
- Fluphenazine
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Furosemide
- Gabapentin
- Ganirelix
- General anesthetics
- Goserelin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Iloperidone
- Iloprost
- Imipramine
- Indapamide
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Isradipine
- Ketamine
- Labetalol
- Lasmiditan
- Leuprolide
- Leuprolide; Norethindrone
- Levocetirizine
- Levodopa
- Levorphanol
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lofexidine
- Loop diuretics
- Losartan
- Loxapine
- Lumateperone
- Lurasidone
- Mecamylamine
- Meclizine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metaxalone
- Methadone
- Methamphetamine
- Methohexital
- Methyclothiazide
- Methyldopa
- Methylphenidate
- Metoclopramide
- Metolazone
- Metoprolol
- Metyrosine
- Minoxidil
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nalbuphine
- Nebivolol
- Nebivolol; Valsartan
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitroprusside
- Non-Ionic Contrast Media
- Norepinephrine
- Nortriptyline
- Obeticholic Acid
- Olanzapine
- Olmesartan
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Opiate Agonists
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paliperidone
- Pemoline
- Penbutolol
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Pergolide
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Pimozide
- Pindolol
- Potassium-sparing diuretics
- Pramipexole
- Pregabalin
- Prilocaine; Epinephrine
- Primidone
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Quetiapine
- Quinapril
- Ramipril
- Rasagiline
- Remifentanil
- Reserpine
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Risperidone
- Ropinirole
- Rotigotine
- Sacubitril; Valsartan
- Secobarbital
- Sedating H1-blockers
- Selegiline
- Sevoflurane
- Skeletal Muscle Relaxants
- Sodium Bicarbonate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Spironolactone
- Sufentanil
- Telmisartan
- Tetrabenazine
- Thalidomide
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Tizanidine
- Tolcapone
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Triamterene
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triprolidine
- Triptorelin
- Trospium
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vasodilators
- Verapamil
- Vigabatrin
- Zaleplon
- Ziprasidone
- Zolpidem
- Zonisamide
