Thiethylperazine

What is Thiethylperazine

NOTE: This drug is discontinued in the US.

Thiethylperazine is a piperazine phenothiazine.

It has antiemetic activity that is greater than its tranquilizing action compared with other phenothiazines, and the only approved use of thiethylperazine is as an antiemetic.

It is most closely related to the high-potency neuroleptics such as perphenazine.

Thiethylperazine was approved by the FDA in 1961.

Brand Name

Torecan

Indications

  • nausea/vomiting

Side Effects

  1. agranulocytosis
  2. akathisia
  3. blurred vision
  4. constipation
  5. contact dermatitis
  6. dizziness
  7. drowsiness
  8. dystonic reaction
  9. erythema
  10. galactorrhea
  11. gynecomastia
  12. hyperprolactinemia
  13. hyperthermia
  14. hypothermia
  15. jaundice
  16. keratopathy
  17. neuroleptic malignant syndrome
  18. neutropenia
  19. orthostatic hypotension
  20. photosensitivity
  21. priapism
  22. pseudoparkinsonism
  23. retinopathy
  24. seizures
  25. skin hyperpigmentation
  26. tardive dyskinesia
  27. thrombocytopenia
  28. urinary retention
  29. urticaria
  30. withdrawal
  31. xerostomia

Monitoring Parameters

  • CBC
  • LFTs

Contraindications

  • agranulocytosis
  • bone marrow suppression
  • breast-feeding
  • cardiac disease
  • children
  • CNS depression
  • coadministration with other CNS depressants
  • coma
  • driving or operating machinery
  • ethanol ingestion
  • geriatric
  • glaucoma
  • hepatic disease
  • hypotension
  • infants
  • intravenous administration
  • jaundice
  • neonates
  • neurological disease
  • orthostatic hypotension
  • Parkinson’s disease
  • phenothiazine hypersensitivity
  • pheochromocytoma
  • pregnancy
  • prostatic hypertrophy
  • radiographic contrast administration
  • seizures
  • sulfite hypersensitivity
  • tardive dyskinesia
  • tartrazine dye hypersensitivity
  • urinary retention

Interactions

  • Abarelix
  • Acarbose
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetohexamide
  • Alfentanil
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amantadine
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amobarbital
  • Amoxapine
  • Anxiolytics; Sedatives; and Hypnotics
  • Apraclonidine
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol; Chlorthalidone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzodiazepines
  • Bepridil
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cabergoline
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Cenobamate
  • Central-acting adrenergic agents
  • Cetrorelix
  • Charcoal
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Citalopram
  • Clindamycin; Tretinoin
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Codeine; Phenylephrine; Promethazine
  • COMT inhibitors
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desvenlafaxine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Diazepam
  • Diethylpropion
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dorzolamide; Timolol
  • Dronabinol
  • Droperidol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Epinephrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Ethotoin
  • Etomidate
  • Felbamate
  • Flibanserin
  • Flucytosine
  • Fluocinolone; Hydroquinone; Tretinoin
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurazepam
  • food
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Fospropofol
  • Ganirelix
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Goserelin
  • Guaifenesin; Phenylephrine
  • Guanidine
  • Halobetasol; Tazarotene
  • Halofantrine
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Incretin Mimetics
  • Indapamide
  • Insulins
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Ipecac
  • Isocarboxazid
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isosulfan Blue
  • Lamotrigine
  • Lemborexant
  • Levetiracetam
  • Levodopa
  • Levomethadyl
  • Linagliptin
  • Linagliptin; Metformin
  • Lomefloxacin
  • Lorazepam
  • Magnesium Salts
  • Maprotiline
  • Meglitinides
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mequinol; Tretinoin
  • Mestranol; Norethindrone
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methocarbamol
  • Methohexital
  • Methoxsalen
  • Methsuximide
  • Methyclothiazide
  • Methylphenidate
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Metyrapone
  • Metyrosine
  • Midazolam
  • Miglitol
  • Minocycline
  • Mitotane
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Naltrexone
  • Nitroglycerin
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Olanzapine
  • Omeprazole; Amoxicillin; Rifabutin
  • Oxazepam
  • Oxycodone
  • Pemoline
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Photosensitizing agents (topical)
  • Pilocarpine
  • Pindolol
  • Pioglitazone
  • Porfimer
  • Pramipexole
  • Pramlintide
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Propoxyphene
  • Propranolol
  • Quazepam
  • Quetiapine
  • Rasagiline
  • Remifentanil
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Safinamide
  • Saxagliptin
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • SGLT2 Inhibitors
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium Oxybate
  • Sparfloxacin
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfonylureas
  • Tazarotene
  • Temazepam
  • Teniposide
  • Thalidomide
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Tiagabine
  • Timolol
  • tobacco
  • Tolazamide
  • Tolbutamide
  • Topiramate
  • Tramadol
  • Tretinoin, ATRA
  • Triazolam
  • Tricyclic antidepressants
  • Trimethobenzamide
  • Trospium
  • Valproic Acid, Divalproex Sodium
  • Vardenafil
  • Venlafaxine
  • Verteporfin
  • Vigabatrin
  • Zaleplon
  • Ziconotide
  • Zolpidem
  • Zonisamide
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