What is Thiethylperazine
NOTE: This drug is discontinued in the US.
Thiethylperazine is a piperazine phenothiazine.
It has antiemetic activity that is greater than its tranquilizing action compared with other phenothiazines, and the only approved use of thiethylperazine is as an antiemetic.
It is most closely related to the high-potency neuroleptics such as perphenazine.
Thiethylperazine was approved by the FDA in 1961.
Brand Name
Torecan
Indications
- nausea/vomiting
Side Effects
- agranulocytosis
- akathisia
- blurred vision
- constipation
- contact dermatitis
- dizziness
- drowsiness
- dystonic reaction
- erythema
- galactorrhea
- gynecomastia
- hyperprolactinemia
- hyperthermia
- hypothermia
- jaundice
- keratopathy
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- photosensitivity
- priapism
- pseudoparkinsonism
- retinopathy
- seizures
- skin hyperpigmentation
- tardive dyskinesia
- thrombocytopenia
- urinary retention
- urticaria
- withdrawal
- xerostomia
Monitoring Parameters
- CBC
- LFTs
Contraindications
- agranulocytosis
- bone marrow suppression
- breast-feeding
- cardiac disease
- children
- CNS depression
- coadministration with other CNS depressants
- coma
- driving or operating machinery
- ethanol ingestion
- geriatric
- glaucoma
- hepatic disease
- hypotension
- infants
- intravenous administration
- jaundice
- neonates
- neurological disease
- orthostatic hypotension
- Parkinson’s disease
- phenothiazine hypersensitivity
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- radiographic contrast administration
- seizures
- sulfite hypersensitivity
- tardive dyskinesia
- tartrazine dye hypersensitivity
- urinary retention
Interactions
- Abarelix
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetohexamide
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amantadine
- Amifampridine
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxapine
- Anxiolytics; Sedatives; and Hypnotics
- Apraclonidine
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol; Chlorthalidone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Bepridil
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capsaicin; Metaxalone
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Phenylephrine
- Cariprazine
- Carisoprodol
- Carteolol
- Cenobamate
- Central-acting adrenergic agents
- Cetrorelix
- Charcoal
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Phenylephrine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Citalopram
- Clindamycin; Tretinoin
- Clobazam
- Clonazepam
- Clorazepate
- Codeine; Phenylephrine; Promethazine
- COMT inhibitors
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desvenlafaxine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Diazepam
- Diethylpropion
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dorzolamide; Timolol
- Dronabinol
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Epinephrine
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Estazolam
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etomidate
- Felbamate
- Flibanserin
- Flucytosine
- Fluocinolone; Hydroquinone; Tretinoin
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- food
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Ganirelix
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Goserelin
- Guaifenesin; Phenylephrine
- Guanidine
- Halobetasol; Tazarotene
- Halofantrine
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydroxyzine
- Ibuprofen; Oxycodone
- Incretin Mimetics
- Indapamide
- Insulins
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Ipecac
- Isocarboxazid
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Lamotrigine
- Lemborexant
- Levetiracetam
- Levodopa
- Levomethadyl
- Linagliptin
- Linagliptin; Metformin
- Lomefloxacin
- Lorazepam
- Magnesium Salts
- Maprotiline
- Meglitinides
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mequinol; Tretinoin
- Mestranol; Norethindrone
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methocarbamol
- Methohexital
- Methoxsalen
- Methsuximide
- Methyclothiazide
- Methylphenidate
- Metoclopramide
- Metolazone
- Metoprolol
- Metyrapone
- Metyrosine
- Midazolam
- Miglitol
- Minocycline
- Mitotane
- Nabilone
- Nadolol
- Nafarelin
- Nalbuphine
- Naltrexone
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Olanzapine
- Omeprazole; Amoxicillin; Rifabutin
- Oxazepam
- Oxycodone
- Pemoline
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pilocarpine
- Pindolol
- Pioglitazone
- Porfimer
- Pramipexole
- Pramlintide
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Propoxyphene
- Propranolol
- Quazepam
- Quetiapine
- Rasagiline
- Remifentanil
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Ropinirole
- Rosiglitazone
- Rotigotine
- Safinamide
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Oxybate
- Sparfloxacin
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfonylureas
- Tazarotene
- Temazepam
- Teniposide
- Thalidomide
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tiagabine
- Timolol
- tobacco
- Tolazamide
- Tolbutamide
- Topiramate
- Tramadol
- Tretinoin, ATRA
- Triazolam
- Tricyclic antidepressants
- Trimethobenzamide
- Trospium
- Valproic Acid, Divalproex Sodium
- Vardenafil
- Venlafaxine
- Verteporfin
- Vigabatrin
- Zaleplon
- Ziconotide
- Zolpidem
- Zonisamide
