Saxagliptin

What is Saxagliptin

Saxagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor and is used in the treatment of type 2 diabetes mellitus (DM) in adults. DPP-4 inhibitors potentiate the effects of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), by inhibiting their breakdown by DPP-4.

Among treatment-naive adults receiving saxagliptin with a baseline mean hemoglobin A1C of 7.7% to 8%, the mean reduction in A1C was 0.7% to 0.9%; clinical trials pre-market reported mean A1C reductions of 0.4 to 0.5%.

Brand Name

Onglyza

Indications

  • type 2 diabetes mellitus

Side Effects

  • abdominal pain
  • anaphylactoid reactions
  • angioedema
  • arthralgia
  • bone fractures
  • bullous rash
  • exfoliative dermatitis
  • headache
  • heart failure
  • hypoglycemia
  • infection
  • lymphopenia
  • pancreatitis
  • pemphigus
  • peripheral edema
  • pharyngitis
  • rash
  • renal failure (unspecified)
  • rhabdomyolysis
  • sinusitis
  • thrombocytopenia
  • urticaria
  • vomiting

Monitoring Parameters

  • blood glucose
  • glycosylated hemoglobin A1c (HbA1c)
  • serum creatinine/BUN

Contraindications

  • adrenal insufficiency
  • arthralgia
  • breast-feeding
  • burns
  • cardiac disease
  • children
  • diabetic ketoacidosis
  • diarrhea
  • exfoliative dermatitis
  • fever
  • gastroparesis
  • geriatric
  • GI obstruction
  • heart failure
  • history of angioedema
  • hypercortisolism
  • hyperglycemia
  • hyperthyroidism
  • hypoglycemia
  • hypothyroidism
  • ileus
  • infection
  • malnutrition
  • pancreatitis
  • pituitary insufficiency
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • serious rash
  • surgery
  • trauma
  • type 1 diabetes mellitus
  • vomiting

Interactions

  • Acebutolol
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  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
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