Vitamin B1 (Thiamine)

What is Vitamin B1 (Thiamine)

Thiamine, or vitamin B1, is a water-soluble vitamin found in such foods as yeast, cereal grains, legumes, peas, nuts, pork, and beef.

Thiamine deficiency causes beriberi.

Thiamine is also used to prevent peripheral neuritis associated with pellagra and pregnancy.

This vitamin is also beneficial in treating metabolic disorders associated with subacute necrotizing encephalomyelopathy, branched-chain aminoacidopathy, and lactic acidosis associated with pyruvate carboxylase deficiency.

Thiamine is considered a standard agent in the treatment of a patient with undiagnosed coma. Thiamine was approved by the FDA at its inception in 1938.

Indications

  • beriberi
  • maple syrup urine disease (MSUD)
  • nutritional supplementation
  • Wernicke/Korsakoff syndrome

For nutritional supplementation

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. cyanosis
  4. diaphoresis
  5. GI bleeding
  6. injection site reaction
  7. nausea
  8. pruritus
  9. pulmonary edema
  10. restlessness
  11. sneezing
  12. urticaria
  13. weakness

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • encephalopathy
  • pregnancy

Interactions

There are no drug interactions associated with Thiamine, Vitamin B1 products.

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