Temazepam

What is Temazepam

Temazepam is an oral benzodiazepine used as a hypnotic agent in the short-term management of insomnia.

It is often preferable to flurazepam for insomnia, particularly in the elderly or patients with liver disease, because temazepam has a shorter half-life and does not have active metabolites.

Temazepam was approved by the FDA in 1981.

Brand Name

Restoril

Indications

  • insomnia

For the short-term treatment of insomnia

Side Effects

  1. agitation
  2. amnesia
  3. anaphylactoid reactions
  4. angioedema
  5. anxiety
  6. ataxia
  7. back pain
  8. blurred vision
  9. complex sleep-related behaviors
  10. confusion
  11. diarrhea
  12. dizziness
  13. drowsiness
  14. dyspnea
  15. euphoria
  16. fatigue
  17. hallucinations
  18. hyperhidrosis
  19. hypotension
  20. insomnia
  21. lethargy
  22. memory impairment
  23. nausea
  24. neonatal abstinence syndrome
  25. neonatal respiratory depression
  26. nightmares
  27. nystagmus
  28. ocular irritation
  29. palpitations
  30. physiological dependence
  31. psychological dependence
  32. respiratory depression
  33. restlessness
  34. somnambulism
  35. teratogenesis
  36. tolerance
  37. tremor
  38. vertigo
  39. vomiting
  40. weakness
  41. withdrawal

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • alcoholism
  • benzodiazepine dependence
  • benzodiazepine hypersensitivity
  • bipolar disorder
  • breast-feeding
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • CNS depression
  • coadministration with other CNS depressants
  • complex sleep-related behaviors
  • dementia
  • depression
  • driving or operating machinery
  • ethanol ingestion
  • ethanol intoxication
  • geriatric
  • hepatic disease
  • infants
  • labor
  • mania
  • myasthenia gravis
  • neonates
  • obstetric delivery
  • pain
  • Parkinson’s disease
  • porphyria
  • pregnancy
  • psychosis
  • pulmonary disease
  • renal failure
  • renal impairment
  • respiratory depression
  • respiratory insufficiency
  • seizure disorder
  • seizures
  • sleep apnea
  • status epilepticus
  • substance abuse
  • suicidal ideation

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alfentanil
  • Alprazolam
  • Amobarbital
  • Amoxapine
  • Apomorphine
  • Apraclonidine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atracurium
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benztropine
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone; Clonidine
  • Cisapride
  • Cisatracurium
  • Clemastine
  • Clobazam
  • Clonidine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Cyclizine
  • Cyproheptadine
  • Desflurane
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dicyclomine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxacurium
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Enflurane
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Etomidate
  • Fentanyl
  • Flumazenil
  • Fluoxetine; Olanzapine
  • food
  • Fosphenytoin
  • Fospropofol
  • Gabapentin
  • General anesthetics
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Guanfacine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Isoflurane
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Lithium
  • Lofexidine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Methadone
  • Methocarbamol
  • Methohexital
  • Methscopolamine
  • Methyldopa
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Milnacipran
  • Minocycline
  • Mirtazapine
  • Mivacurium
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Neuromuscular blockers
  • Nitroglycerin
  • Olanzapine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pancuronium
  • Papaverine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Phenobarbital
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimozide
  • Pramipexole
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Pregabalin
  • Primidone
  • Probenecid
  • Procarbazine
  • Propofol
  • Propoxyphene
  • Quetiapine
  • Ramelteon
  • Rapacuronium
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rocuronium
  • Rotigotine
  • Safinamide
  • Scopolamine
  • Secobarbital
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Sevoflurane
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Oxybate
  • Succinylcholine
  • Sufentanil
  • Suvorexant
  • Tapentadol
  • Teduglutide
  • Tetrabenazine
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiopental
  • Thiothixene
  • Tiagabine
  • Tizanidine
  • Topiramate
  • Tramadol
  • Trazodone
  • Tricyclic antidepressants
  • Trihexyphenidyl
  • Trimethobenzamide
  • Triprolidine
  • Tubocurarine
  • Valerian, Valeriana officinalis
  • Vecuronium
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziprasidone
  • Zolpidem
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