What is Selexipag
Selexipag is an oral, selective prostacyclin receptor (IP receptor) agonist for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH.
Current pharmacologic options for the treatment of PAH are targeted to specific pathways involved in the disease process; many patients require combination therapy with agents from different classes.
Brand Name
UPTRAVI
Indications
- pulmonary hypertension
For the treatment of pulmonary hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization
Side Effects
- anemia
- anorexia
- arthralgia
- diarrhea
- flushing
- headache
- hyperthyroidism
- hypotension
- myalgia
- nausea
- pulmonary edema
- rash
- veno-occlusive disease (VOD)
- vomiting
Monitoring Parameters
- blood pressure
Contraindications
- breast-feeding
- pregnancy
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Articaine; Epinephrine
- Benzphetamine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cannabidiol
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clopidogrel
- Codeine; Phenylephrine; Promethazine
- Deferasirox
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Duloxetine
- Elbasvir; Grazoprevir
- Ephedrine
- Epinephrine
- Fexofenadine; Pseudoephedrine
- Gemfibrozil
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Lapatinib
- Leflunomide
- Letermovir
- Lisdexamfetamine
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lurasidone
- Mepivacaine; Levonordefrin
- Methamphetamine
- Methylphenidate
- Midodrine
- Naproxen; Pseudoephedrine
- Nicardipine
- Norepinephrine
- Pemoline
- Phendimetrazine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Prilocaine; Epinephrine
- Pseudoephedrine
- Racepinephrine
- Rifampin
- Ritodrine
- Sapropterin
- Selpercatinib
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sympathomimetics
- Tedizolid
- Teriflunomide
- Trimethoprim
- Zonisamide
