Selexipag

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What is Selexipag

Selexipag is an oral, selective prostacyclin receptor (IP receptor) agonist for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH.

Current pharmacologic options for the treatment of PAH are targeted to specific pathways involved in the disease process; many patients require combination therapy with agents from different classes.

Brand Name

UPTRAVI

Indications

  • pulmonary hypertension

For the treatment of pulmonary hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization

Side Effects

  • anemia
  • anorexia
  • arthralgia
  • diarrhea
  • flushing
  • headache
  • hyperthyroidism
  • hypotension
  • myalgia
  • nausea
  • pulmonary edema
  • rash
  • veno-occlusive disease (VOD)
  • vomiting

Monitoring Parameters

  • blood pressure

Contraindications

  • breast-feeding
  • pregnancy

Interactions

  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Articaine; Epinephrine
  • Benzphetamine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Cannabidiol
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Clopidogrel
  • Codeine; Phenylephrine; Promethazine
  • Deferasirox
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dobutamine
  • Dopamine
  • Duloxetine
  • Elbasvir; Grazoprevir
  • Ephedrine
  • Epinephrine
  • Fexofenadine; Pseudoephedrine
  • Gemfibrozil
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen; Pseudoephedrine
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Lapatinib
  • Leflunomide
  • Letermovir
  • Lisdexamfetamine
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Lurasidone
  • Mepivacaine; Levonordefrin
  • Methamphetamine
  • Methylphenidate
  • Midodrine
  • Naproxen; Pseudoephedrine
  • Nicardipine
  • Norepinephrine
  • Pemoline
  • Phendimetrazine
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Prilocaine; Epinephrine
  • Pseudoephedrine
  • Racepinephrine
  • Rifampin
  • Ritodrine
  • Sapropterin
  • Selpercatinib
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sympathomimetics
  • Tedizolid
  • Teriflunomide
  • Trimethoprim
  • Zonisamide

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