Repaglinide

What is Repaglinide

Repaglinide is a meglitinide oral hypoglycemic agent given before meals and is used as an adjunct to diet and exercise in the treatment of type 2 diabetes mellitus (DM) in adults.

Brand Name

Prandin

Indications

  • type 2 diabetes mellitus

For the treatment of type 2 diabetes mellitus uncontrolled by diet and exercise alone

Side Effects

  1. alopecia
  2. anaphylactoid reactions
  3. angina
  4. arrhythmia exacerbation
  5. arthralgia
  6. back pain
  7. chest pain (unspecified)
  8. confusion
  9. constipation
  10. diarrhea
  11. dyspepsia
  12. elevated hepatic enzymes
  13. headache
  14. heart failure
  15. hemolytic anemia
  16. hepatitis
  17. hypertension
  18. hypoglycemia
  19. infection
  20. jaundice
  21. leukopenia
  22. myocardial infarction
  23. nausea
  24. pallor
  25. palpitations
  26. pancreatitis
  27. paresthesias
  28. peripheral edema
  29. rhinitis
  30. secondary failure
  31. sinus tachycardia
  32. sinusitis
  33. Stevens-Johnson syndrome
  34. thrombocytopenia
  35. tremor
  36. vomiting
  37. weight gain

Monitoring Parameters

  • blood glucose
  • glycosylated hemoglobin A1c (HbA1c)

Contraindications

  • breast-feeding
  • children
  • diabetic ketoacidosis
  • fever
  • geriatric
  • hepatic disease
  • hypoglycemia
  • infants
  • infection
  • pregnancy
  • surgery
  • trauma
  • type 1 diabetes mellitus

Interactions

  • Abiraterone
  • Acebutolol
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alogliptin; Metformin
  • Amiodarone
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Androgens
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendroflumethiazide; Nadolol
  • Benzphetamine
  • Beta-blockers
  • Betaxolol
  • Bexarotene
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Bortezomib
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Butabarbital
  • Canagliflozin; Metformin
  • Cannabidiol
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Ceritinib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloramphenicol
  • Chloroquine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Chromium
  • Cimetidine
  • Cisapride
  • Clarithromycin
  • Clofarabine
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  • Clopidogrel
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  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
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  • Darunavir; Cobicistat
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  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Delavirdine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Diazoxide
  • Dienogest; Estradiol valerate
  • Diethylpropion
  • Diethylstilbestrol, DES
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Disopyramide
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  • Dronedarone
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  • Efavirenz
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  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Elexacaftor; tezacaftor; ivacaftor
  • Eltrombopag
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enzalutamide
  • Ephedrine
  • Epinephrine
  • Ertugliflozin; Metformin
  • Erythromycin
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  • Esmolol
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  • Estradiol; Norgestimate
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  • Estramustine
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  • Ethanol
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  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Etonogestrel
  • Exenatide
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  • Garlic, Allium sativum
  • Gemfibrozil
  • Glecaprevir; Pibrentasvir
  • Glipizide; Metformin
  • Glyburide; Metformin
  • grapefruit juice
  • Green Tea
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxychloroquine
  • Hydroxyprogesterone
  • Ibuprofen; Pseudoephedrine
  • Idelalisib
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  • Indapamide
  • Insulin Glargine; Lixisenatide
  • Isavuconazonium
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  • Isoniazid, INH; Rifampin
  • Isoproterenol
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  • Ketoconazole
  • Labetalol
  • Lanreotide
  • Ledipasvir; Sofosbuvir
  • Leflunomide
  • Letermovir
  • Leuprolide; Norethindrone
  • Levobetaxolol
  • Levobunolol
  • Levonorgestrel
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Lisdexamfetamine
  • Lithium
  • Lixisenatide
  • Lomefloxacin
  • Loop diuretics
  • Loratadine; Pseudoephedrine
  • Lorcaserin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Medroxyprogesterone
  • Meperidine; Promethazine
  • Mephobarbital
  • Mepivacaine; Levonordefrin
  • Mesoridazine
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methamphetamine
  • Methazolamide
  • Methohexital
  • Methylphenidate
  • Methyltestosterone
  • Metoprolol
  • Metreleptin
  • Metyrapone
  • Midodrine
  • Mifepristone
  • Mitotane
  • Monoamine oxidase inhibitors
  • Nadolol
  • Nandrolone Decanoate
  • Naproxen; Pseudoephedrine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nicardipine
  • Nicotine
  • Norepinephrine
  • Norethindrone
  • Norgestrel
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oritavancin
  • Orlistat
  • Oxandrolone
  • Oxymetholone
  • Pasireotide
  • Pazopanib
  • Pegvisomant
  • Pemoline
  • Penbutolol
  • Pentamidine
  • Pentobarbital
  • Pentoxifylline
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenobarbital
  • Phenothiazines
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pindolol
  • Posaconazole
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prilocaine; Epinephrine
  • Primidone
  • Prochlorperazine
  • Progesterone
  • Progestins
  • Promethazine
  • Propoxyphene
  • Propranolol
  • Protease inhibitors
  • Pseudoephedrine
  • Pyrimethamine; Sulfadoxine
  • Quinine
  • Quinolones
  • Racepinephrine
  • Ranolazine
  • Regular Insulin; Isophane Insulin (NPH)
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritodrine
  • Salicylates
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Somatropin, rh-GH
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Sympathomimetics
  • Tacrolimus
  • Tegaserod
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Teriflunomide
  • Testolactone
  • Testosterone
  • Thiazide diuretics
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thyroid hormones
  • Timolol
  • tobacco
  • Tolvaptan
  • Trandolapril; Verapamil
  • Trifluoperazine
  • Trimethoprim
  • Tucatinib
  • Vemurafenib
  • Verapamil
  • Voriconazole
  • Zafirlukast
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