Sincalide

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What is Sincalide

Sincalide is a synthetically prepared cholecystopancreatic-gastrointestinal hormone peptide for parenteral administration. Structurally, it is an eight chain peptide of the C-terminal of cholecystokinin.

Activities include gallbladder contraction, sphincter of Oddi relaxation, hepatic bile secretion, pancreatic secretion stimulation, and intestinal smooth muscle stimulation.

Sincalide has been studied in the treatment and prevention of parenteral nutrition-associated cholestasis (PNAC), predominantly in children. 

Brand Name

Kinevac

Indications & Dosage

  • exocrine pancreatic dysfunction diagnosis
  • gallbladder contraction stimulation
  • hepatobiliary system dysfunction diagnosis
  • pancreatic secretion stimulation
  • radiation exposure

For pancreatic secretion stimulation to aid in exocrine pancreatic dysfunction diagnosis

NOTE: For use in conjunction with secretin, for the Secretin-Kinevac test of pancreatic function.

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. bradycardia
  4. diaphoresis
  5. diarrhea
  6. dizziness
  7. dyspnea
  8. fecal urgency
  9. flushing
  10. headache
  11. hypertension
  12. hypotension
  13. nausea
  14. pruritus
  15. rash
  16. seizures
  17. sneezing
  18. syncope
  19. throat irritation
  20. vomiting

Monitoring Parameters

  • gallbladder ultrasound
  • LFTs
  • serum bilirubin

Contraindications

  • biliary obstruction
  • breast-feeding
  • cholelithiasis
  • GI obstruction
  • hepatic disease
  • inflammatory bowel disease
  • infusion-related reactions
  • pancreatitis
  • pregnancy
  • surgery

Interactions

  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acrivastine; Pseudoephedrine
  • Anticholinergics
  • Benzodiazepines
  • Bethanechol
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Calcium-channel blockers
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorcyclizine
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Clemastine
  • Cyclizine
  • Cyproheptadine
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Estradiol; Progesterone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • food
  • Hydroxyzine
  • Indomethacin
  • Levocetirizine
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Meclizine
  • Mestranol; Norethindrone
  • Morphine
  • Morphine; Naltrexone
  • Nitrates
  • Octreotide
  • Phentolamine
  • Progesterone
  • Secretin
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Theophylline, Aminophylline
  • Triprolidine

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