What's on this Page
What is Temozolomide
Temozolomide is an alkylating agent that is indicated for the treatment of newly diagnosed glioblastoma multiforme in combination with radiotherapy followed by monotherapy maintenance therapy and for the treatment of refractory anaplastic astrocytoma in patients who have experienced disease progression after a nitrosourea and procarbazine-containing regimen.
Severe hematologic toxicity and hepatotoxicity have been reported with temozolomide therapy.
Brand Name
TEMODAR
Indications
- astrocytoma
- glioblastoma multiforme
- malignant glioma
- malignant melanoma
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- amnesia
- amnesia
- anaphylactoid reactions
- anemia
- anorexia
- anorexia
- anxiety
- anxiety
- aplastic anemia
- arthralgia
- arthralgia
- asthenia
- asthenia
- ataxia
- ataxia
- back pain
- back pain
- blurred vision
- blurred vision
- cholestasis
- confusion
- confusion
- constipation
- constipation
- cough
- cough
- Cushing’s syndrome
- depression
- diabetes insipidus
- diarrhea
- diarrhea
- diplopia
- dizziness
- dizziness
- drowsiness
- drowsiness
- dysgeusia
- dysphagia
- dysphagia
- dyspnea
- dyspnea
- edema
- elevated hepatic enzymes
- erythema
- erythema multiforme
- fatigue
- fatigue
- fever
- fever
- headache
- headache
- hematoma
- hepatitis
- hyperbilirubinemia
- increased urinary frequency
- infection
- injection site reaction
- insomnia
- leukopenia
- lymphopenia
- mastalgia
- memory impairment
- memory impairment
- myalgia
- nausea
- nausea
- neutropenia
- new primary malignancy
- pancytopenia
- paresis
- paresis
- paresthesias
- paresthesias
- peripheral edema
- peripheral edema
- petechiae
- pharyngitis
- pneumonitis
- pruritus
- pruritus
- pulmonary fibrosis
- rash
- rash
- seizures
- sinusitis
- skin irritation
- spontaneous fetal abortion
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- teratogenesis
- thrombocytopenia
- thrombocytopenia
- toxic epidermal necrolysis
- urinary incontinence
- urinary incontinence
- visual impairment
- vomiting
- vomiting
- weakness
- weakness
- weight gain
- xerosis
- xerosis
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
Contraindications
- aplastic anemia
- bone marrow suppression
- breast-feeding
- children
- contraception requirements
- dacarbazine (DTIC) hypersensitivity
- females
- gelatin hypersensitivity
- geriatric
- glioblastoma multiforme
- hepatic disease
- hepatotoxicity
- infants
- infection
- infertility
- male-mediated teratogenicity
- mannitol hypersensitivity
- neonates
- neutropenia
- pregnancy
- pregnancy testing
- renal disease
- renal impairment
- reproductive risk
- serious rash
- sperm donation
- thrombocytopenia
- urticaria
Interactions
- Aldesleukin, IL-2
- Amlodipine; Celecoxib
- Celecoxib
- Clozapine
- Cyclophosphamide
- Cyclosporine
- Daclizumab
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Echinacea
- Efalizumab
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Flucytosine
- Flurbiprofen
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Live Vaccines
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methotrexate
- Muromonab-CD3
- Mycophenolate
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Penicillamine
- Piroxicam
- Rofecoxib
- Sirolimus
- Sulindac
- Tacrolimus
- Tolmetin
- Tuberculin Purified Protein Derivative, PPD
- Valdecoxib
- Valproic Acid, Divalproex Sodium
