Reserpine

What is Reserpine

Reserpine, an antihypertensive, is a rauwolfia alkaloid derived from the root of Rauwolfia serpentina, a shrub native to India.

Rauwolfia alkaloids were first used for the treatment of hypertension and psychoses in India during the 1930s but were not used in Western medicine until the 1950s.

Reserpine was approved by the FDA in 1953. Reserpine was the first drug found to interfere with the human sympathetic nervous system, and it initiated the effective pharmacotherapeutic control of hypertension.

Recently, the use of reserpine as an antihypertensive agent has diminished due its adverse CNS effects and the advent of newer antihypertensive drugs that are equally effective and much better tolerated.

Use of rauwolfia alkaloids in patients with psychotic disorders has been replaced by treatment with other, more effective agents.

Indications

  • hypertension

Side Effects

  1. anorexia
  2. anxiety
  3. arrhythmia exacerbation
  4. bradycardia
  5. breast enlargement
  6. conjunctivitis
  7. depression
  8. diarrhea
  9. dizziness
  10. drowsiness
  11. dyspnea
  12. dysuria
  13. ejaculation dysfunction
  14. epistaxis
  15. gynecomastia
  16. headache
  17. hearing loss
  18. heart failure
  19. hyperprolactinemia
  20. hypotension
  21. impotence (erectile dysfunction)
  22. libido decrease
  23. miosis
  24. musculoskeletal pain
  25. nasal congestion
  26. nausea
  27. nightmares
  28. optic atrophy
  29. pruritus
  30. pseudoparkinsonism
  31. purpura
  32. rash
  33. syncope
  34. uveitis
  35. vomiting
  36. weight gain
  37. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate

Contraindications

  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • cholelithiasis
  • depression
  • diabetes mellitus
  • electroconvulsive therapy (ECT)
  • geriatric
  • hepatic disease
  • infants
  • MAOI therapy
  • Parkinson’s disease
  • peptic ulcer disease
  • pheochromocytoma
  • pregnancy
  • rauwolfia alkaloid hypersensitivity
  • renal disease
  • salicylate hypersensitivity
  • seizure disorder
  • suicidal ideation
  • tartrazine dye hypersensitivity
  • ulcerative colitis

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acetazolamide
  • Acetohexamide
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Alprostadil
  • Amifostine
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amobarbital
  • Amoxapine
  • Amphetamine; Dextroamphetamine Salts
  • Amyl Nitrite
  • Apomorphine
  • Apraclonidine
  • Aripiprazole
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendroflumethiazide; Nadolol
  • Benzphetamine
  • Beta-adrenergic blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bortezomib
  • Bosentan
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Butabarbital
  • Cabergoline
  • Canagliflozin
  • Canagliflozin; Metformin
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Carbonic anhydrase inhibitors
  • Cardiac glycosides
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Clomipramine
  • Clozapine
  • Co-Enzyme Q10, Ubiquinone
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desipramine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diethylpropion
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dobutamine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxepin
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dulaglutide
  • Duloxetine
  • Eletriptan
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Ephedrine
  • Epinephrine
  • Epoprostenol
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esmolol
  • Esomeprazole; Naproxen
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etodolac
  • Etomidate
  • Exenatide
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Fospropofol
  • General anesthetics
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Goserelin
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Imipramine
  • Incretin Mimetics
  • Indomethacin
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Intravenous Lipid Emulsions
  • Iobenguane I 131
  • Isocarboxazid
  • Isoflurane
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Ketamine
  • Ketoprofen
  • Ketorolac
  • Labetalol
  • Lansoprazole; Naproxen
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Linagliptin
  • Linagliptin; Metformin
  • Linezolid
  • Liraglutide
  • Lisdexamfetamine
  • Lixisenatide
  • Loratadine; Pseudoephedrine
  • Lovastatin; Niacin
  • Lurasidone
  • Maprotiline
  • Mecamylamine
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meglitinides
  • Meloxicam
  • Mephobarbital
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methamphetamine
  • Methazolamide
  • Methohexital
  • Methylphenidate
  • Metoprolol
  • Midodrine
  • Miglitol
  • Milrinone
  • Monoamine oxidase inhibitors
  • Nabumetone
  • Nadolol
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nateglinide
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nesiritide, BNP
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Nortriptyline
  • Olanzapine
  • Oxaprozin
  • Oxymetazoline
  • Paliperidone
  • Penbutolol
  • Pentobarbital
  • Pentoxifylline
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pindolol
  • Pioglitazone
  • Piroxicam
  • Pramlintide
  • Prazosin
  • Prilocaine; Epinephrine
  • Primidone
  • Procainamide
  • Procaine
  • Procarbazine
  • Propofol
  • Propranolol
  • Protriptyline
  • Pseudoephedrine
  • Quinidine
  • Rasagiline
  • Repaglinide
  • Risperidone
  • Ritodrine
  • Rofecoxib
  • Rosiglitazone
  • Saxagliptin
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Semaglutide
  • Sevoflurane
  • Silodosin
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sotalol
  • Sulfonylureas
  • Sulindac
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Timolol
  • Tizanidine
  • Tolazamide
  • Tolbutamide
  • Tolmetin
  • Tranylcypromine
  • Trazodone
  • Tricyclic antidepressants
  • Trimipramine
  • Triptorelin
  • Valdecoxib
  • Yohimbine
  • Ziprasidone