Telotristat Ethyl

What is Telotristat Ethyl

Telotristat ethyl is an orally available tryptophan hydroxylase inhibitor. Tryptophan hydroxylase mediates the rate-limiting step in the formation of serotonin, which is overproduced in patients with carcinoid syndrome and contributes to altered gastrointestinal secretion, motility, inflammation, and sensation.

In a multicenter, randomized, double-blind clinical trial, telotristat ethyl significantly decreased the number of daily bowel movements compared with placebo in patients with well-differentiated metastatic neuroendocrine tumor and carcinoid syndrome diarrhea concurrently treated with a somatostatin analog. 

Brand Name

Xermelo

Indications

  • carcinoid

For the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients inadequately controlled by SSA therapy

Side Effects

  1. abdominal pain
  2. anorexia
  3. constipation
  4. depression
  5. elevated hepatic enzymes
  6. fever
  7. flatulence
  8. GI obstruction
  9. GI perforation
  10. headache
  11. nausea
  12. peripheral edema

Contraindications

  • abdominal pain
  • breast-feeding
  • constipation
  • GI obstruction
  • GI perforation
  • pregnancy

Interactions

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