Telaprevir

What is Telaprevir

Telaprevir is an NS3/4A protease inhibitor, indicated for the treatment of genotype 1 chronic hepatitis C infection in adults with compensated liver disease who are treatment-naive or who have previously had an inadequate responded to interferon-based drug therapy.

Telaprevir must be used in combination with peginterferon alfa and ribavirin; therefore, precautions applying to peginterferon alfa and ribavirin also apply to telaprevir.

Approval of telaprevir was based on the results of two placebo-controlled trials, ADVANCE (treatment-naive patients) and REALIZE (patients with previous inadequate response to interferon-based treatment).

Brand Name

INCIVEK

Indications

  • hepatitis C infection
  • hepatitis C virus

Side Effects

  1. anemia
  2. azotemia
  3. bullous rash
  4. diarrhea
  5. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  6. dysgeusia
  7. eosinophilia
  8. erythema multiforme
  9. fatigue
  10. fever
  11. gout
  12. hemorrhoids
  13. hyperbilirubinemia
  14. hyperuricemia
  15. leukopenia
  16. lymphopenia
  17. nausea
  18. neutropenia
  19. pruritus
  20. pruritus ani
  21. rash
  22. rash
  23. renal failure (unspecified)
  24. skin erosion
  25. Stevens-Johnson syndrome
  26. thrombocytopenia
  27. toxic epidermal necrolysis
  28. vesicular rash
  29. vomiting

Monitoring Parameters

  • CBC with differential
  • hemoglobin/hematocrit
  • LFTs
  • plasma hepatitis C RNA
  • pregnancy testing
  • serum bilirubin
  • serum creatinine/BUN
  • serum electrolytes
  • serum uric acid
  • thyroid function tests (TFTs)

Contraindications

  • anemia
  • breast-feeding
  • children
  • hepatic disease
  • hepatitis C and HIV coinfection
  • infants
  • liver transplant
  • male-mediated teratogenicity
  • neonates
  • pregnancy
  • serious rash

Interactions

  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Ado-Trastuzumab emtansine
  • Afatinib
  • Aldesleukin, IL-2
  • Alfentanil
  • Alfuzosin
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alosetron
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Artemether; Lumefantrine
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Azelastine; Fluticasone
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Bepridil
  • Betrixaban
  • Bortezomib
  • Bosentan
  • Bosutinib
  • Brexpiprazole
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Caffeine; Ergotamine
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Carvedilol
  • Cevimeline
  • Chloramphenicol
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofarabine
  • Clomipramine
  • Clonazepam
  • Clozapine
  • Cobicistat
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Conjugated Estrogens; Medroxyprogesterone
  • Cyclosporine
  • Dabigatran
  • Danazol
  • Dapsone
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexamethasone
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dienogest; Estradiol valerate
  • Digoxin
  • Dihydroergotamine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Docetaxel
  • Dolasetron
  • Donepezil
  • Donepezil; Memantine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxorubicin
  • Dronedarone
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dutasteride; Tamsulosin
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Eletriptan
  • Eliglustat
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Escitalopram
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Norethindrone
  • Eszopiclone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Etravirine
  • Ezetimibe; Simvastatin
  • Felodipine
  • Fesoterodine
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Flutamide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvastatin
  • Fluvoxamine
  • Formoterol; Mometasone
  • Fosamprenavir
  • Galantamine
  • Glyburide
  • Glyburide; Metformin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanfacine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibrutinib
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ivermectin
  • Ixabepilone
  • Ketoconazole
  • Lacosamide
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Leuprolide; Norethindrone
  • Levomilnacipran
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin
  • Linagliptin; Metformin
  • Lomitapide
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lovastatin
  • Lovastatin; Niacin
  • Macitentan
  • Maraviroc
  • Medroxyprogesterone
  • Mefloquine
  • Mestranol; Norethindrone
  • Metformin; Repaglinide
  • Methadone
  • Methylergonovine
  • Methylprednisolone
  • Methysergide
  • Midazolam
  • Mifepristone
  • Mitomycin
  • Modafinil
  • Mometasone
  • Morphine
  • Morphine; Naltrexone
  • Nafcillin
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
  • Nintedanib
  • Nisoldipine
  • Norethindrone
  • Nortriptyline
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Ospemifene
  • Oxcarbazepine
  • Oxybutynin
  • Oxycodone
  • Paclitaxel
  • Panobinostat
  • Paricalcitol
  • Pazopanib
  • Perampanel
  • Pergolide
  • Perindopril; Amlodipine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pitavastatin
  • Ponatinib
  • Posaconazole
  • Prednisolone
  • Prednisone
  • Primidone
  • Propafenone
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ramelteon
  • Ranolazine
  • Repaglinide
  • Rifabutin
  • Rifampin
  • Rifaximin
  • Riociguat
  • Risperidone
  • Rivaroxaban
  • Romidepsin
  • Ropivacaine
  • Rosuvastatin
  • Ruxolitinib
  • Salmeterol
  • Saquinavir
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Sibutramine
  • Sildenafil
  • Silodosin
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • Solifenacin
  • Sonidegib
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Tamsulosin
  • Tasimelteon
  • Telithromycin
  • Teniposide
  • Tenofovir, PMPA
  • Terbinafine
  • Terfenadine
  • Testosterone
  • Theophylline, Aminophylline
  • Tiagabine
  • Ticagrelor
  • Tinidazole
  • Tipranavir
  • Tolterodine
  • Tolvaptan
  • Trabectedin
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triazolam
  • Valbenazine
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voriconazole
  • Warfarin
  • Yohimbine
  • Zafirlukast
  • Zileuton
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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