Silodosin

What is Silodosin

Silodosin is a highly selective, oral alpha-1 blocker effective for the treatment of benign prostatic hyperplasia (BPH).

Silodosin is similar to tamsulosin (Flomax®), an alpha-1a-receptor antagonist marketed in the US since 1997.

Silodosin is as effective as tamsulosin for improving lower urinary tract symptoms associated with BPH; however, abnormal ejaculation is reported significantly more often with silodosin than with tamsulosin.

Brand Name

Rapaflo

Indications & Dosage

  • benign prostatic hyperplasia (BPH)

For the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)

NOTE: Silodosin is not indicated for the treatment of hypertension.

Side Effects

  • abdominal pain
  • angioedema
  • asthenia
  • diarrhea
  • dizziness
  • ejaculation dysfunction
  • elevated hepatic enzymes
  • floppy iris syndrome
  • headache
  • insomnia
  • jaundice
  • nasal congestion
  • new primary malignancy
  • orthostatic hypotension
  • pharyngitis
  • polydipsia
  • priapism
  • pruritus
  • purpura
  • rash
  • rhinorrhea
  • sinusitis
  • syncope
  • urinary incontinence
  • urticaria

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • driving or operating machinery
  • females
  • geriatric
  • hepatic disease
  • hypotension
  • infants
  • neonates
  • ocular surgery
  • orthostatic hypotension
  • pregnancy
  • priapism
  • prostate cancer
  • renal disease
  • renal failure
  • renal impairment
  • syncope

Interactions

  • Acebutolol
  • Alfuzosin
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alpha-blockers
  • Ambrisentan
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Aprepitant, Fosaprepitant
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Avanafil
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Beta-adrenergic blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Bosentan
  • Brigatinib
  • Brimonidine; Timolol
  • Bumetanide
  • Cabozantinib
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Capmatinib
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carteolol
  • Carvedilol
  • Central-acting adrenergic agents
  • Ceritinib
  • Chloramphenicol
  • Chlorothiazide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Clarithromycin
  • Clonidine
  • Cobicistat
  • Colchicine; Probenecid
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Daclatasvir
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Diazoxide
  • Diltiazem
  • Dorzolamide; Timolol
  • Doxazosin
  • Dronedarone
  • Dutasteride; Tamsulosin
  • Duvelisib
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esmolol
  • Ethacrynic Acid
  • Ethanol
  • Etravirine
  • Fedratinib
  • Felodipine
  • Fenoldopam
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Glecaprevir; Pibrentasvir
  • grapefruit juice
  • Guanabenz
  • Guanfacine
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Idelalisib
  • Iloprost
  • Imatinib
  • Indapamide
  • Indinavir
  • Irbesartan
  • Isavuconazonium
  • Isradipine
  • Istradefylline
  • Itraconazole
  • Ketoconazole
  • Labetalol
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Levobetaxolol
  • Levobunolol
  • Lisinopril
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Losartan
  • Mecamylamine
  • Methyclothiazide
  • Methyldopa
  • Metolazone
  • Metoprolol
  • Mifepristone
  • Minoxidil
  • Mitotane
  • Moexipril
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitroprusside
  • Olmesartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Penbutolol
  • Perindopril
  • Perindopril; Amlodipine
  • Phenoxybenzamine
  • Phentolamine
  • Pindolol
  • Posaconazole
  • Potassium-sparing diuretics
  • Prazosin
  • Probenecid
  • Propranolol
  • Quinapril
  • Ramipril
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Ritonavir
  • Sacubitril; Valsartan
  • Sapropterin
  • Saquinavir
  • Sildenafil
  • Simeprevir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Spironolactone
  • Tadalafil
  • Tamsulosin
  • Telaprevir
  • Telithromycin
  • Telmisartan
  • Telotristat Ethyl
  • Temsirolimus
  • Terazosin
  • Thiazide diuretics
  • Timolol
  • Tipranavir
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Treprostinil
  • Triamterene
  • Tucatinib
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vardenafil
  • Vemurafenib
  • Verapamil
  • Voriconazole
  • Zafirlukast
  • Zileuton
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