Silodosin

What is Silodosin

Silodosin is a highly selective, oral alpha-1 blocker effective for the treatment of benign prostatic hyperplasia (BPH).

Silodosin is similar to tamsulosin (Flomax®), an alpha-1a-receptor antagonist marketed in the US since 1997.

Silodosin is as effective as tamsulosin for improving lower urinary tract symptoms associated with BPH; however, abnormal ejaculation is reported significantly more often with silodosin than with tamsulosin.

Brand Name

Rapaflo

Indications & Dosage

• benign prostatic hyperplasia (BPH)

For the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)

NOTE: Silodosin is not indicated for the treatment of hypertension.

Side Effects

• abdominal pain
• angioedema
• asthenia
• diarrhea
• dizziness
• ejaculation dysfunction
• elevated hepatic enzymes
• floppy iris syndrome
• headache
• insomnia
• jaundice
• nasal congestion
• new primary malignancy
• orthostatic hypotension
• pharyngitis
• polydipsia
• priapism
• pruritus
• purpura
• rash
• rhinorrhea
• sinusitis
• syncope
• urinary incontinence
• urticaria

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• breast-feeding
• children
• driving or operating machinery
• females
• geriatric
• hepatic disease
• hypotension
• infants
• neonates
• ocular surgery
• orthostatic hypotension
• pregnancy
• priapism
• prostate cancer
• renal disease
• renal failure
• renal impairment
• syncope

Interactions

• Acebutolol
• Alfuzosin
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alpha-blockers
• Ambrisentan
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amprenavir
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Aprepitant, Fosaprepitant
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Avanafil
• Azilsartan
• Azilsartan; Chlorthalidone
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Beta-adrenergic blockers
• Betaxolol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bosentan
• Brigatinib
• Brimonidine; Timolol
• Bumetanide
• Cabozantinib
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Capmatinib
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carteolol
• Carvedilol
• Central-acting adrenergic agents
• Ceritinib
• Chloramphenicol
• Chlorothiazide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Clarithromycin
• Clonidine
• Cobicistat
• Colchicine; Probenecid
• Conivaptan
• Crizotinib
• Cyclosporine
• Daclatasvir
• Danazol
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Diazoxide
• Diltiazem
• Dorzolamide; Timolol
• Doxazosin
• Dronedarone
• Dutasteride; Tamsulosin
• Duvelisib
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Erythromycin
• Erythromycin; Sulfisoxazole
• Esmolol
• Ethacrynic Acid
• Ethanol
• Etravirine
• Fedratinib
• Felodipine
• Fenoldopam
• Fluconazole
• Fluvoxamine
• Fosamprenavir
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Furosemide
• Glecaprevir; Pibrentasvir
• grapefruit juice
• Guanabenz
• Guanfacine
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Idelalisib
• Iloprost
• Imatinib
• Indapamide
• Indinavir
• Irbesartan
• Isavuconazonium
• Isradipine
• Istradefylline
• Itraconazole
• Ketoconazole
• Labetalol
• Ledipasvir; Sofosbuvir
• Lefamulin
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Levobetaxolol
• Levobunolol
• Lisinopril
• Loop diuretics
• Lopinavir; Ritonavir
• Losartan
• Mecamylamine
• Methyclothiazide
• Methyldopa
• Metolazone
• Metoprolol
• Mifepristone
• Minoxidil
• Mitotane
• Moexipril
• Nadolol
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nelfinavir
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitroprusside
• Olmesartan
• Ombitasvir; Paritaprevir; Ritonavir
• Oritavancin
• Penbutolol
• Perindopril
• Perindopril; Amlodipine
• Phenoxybenzamine
• Phentolamine
• Pindolol
• Posaconazole
• Potassium-sparing diuretics
• Prazosin
• Probenecid
• Propranolol
• Quinapril
• Ramipril
• Reserpine
• Ribociclib
• Ribociclib; Letrozole
• Ritonavir
• Sacubitril; Valsartan
• Sapropterin
• Saquinavir
• Sildenafil
• Simeprevir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Spironolactone
• Tadalafil
• Tamsulosin
• Telaprevir
• Telithromycin
• Telmisartan
• Telotristat Ethyl
• Temsirolimus
• Terazosin
• Thiazide diuretics
• Timolol
• Tipranavir
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Treprostinil
• Triamterene
• Tucatinib
• Valproic Acid, Divalproex Sodium
• Valsartan
• Vardenafil
• Vemurafenib
• Verapamil
• Voriconazole
• Zafirlukast
• Zileuton