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What is Silodosin
Silodosin is a highly selective, oral alpha-1 blocker effective for the treatment of benign prostatic hyperplasia (BPH).
Silodosin is similar to tamsulosin (Flomax®), an alpha-1a-receptor antagonist marketed in the US since 1997.
Silodosin is as effective as tamsulosin for improving lower urinary tract symptoms associated with BPH; however, abnormal ejaculation is reported significantly more often with silodosin than with tamsulosin.
Brand Name
Rapaflo
Indications & Dosage
- benign prostatic hyperplasia (BPH)
For the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)
NOTE: Silodosin is not indicated for the treatment of hypertension.
Side Effects
- abdominal pain
- angioedema
- asthenia
- diarrhea
- dizziness
- ejaculation dysfunction
- elevated hepatic enzymes
- floppy iris syndrome
- headache
- insomnia
- jaundice
- nasal congestion
- new primary malignancy
- orthostatic hypotension
- pharyngitis
- polydipsia
- priapism
- pruritus
- purpura
- rash
- rhinorrhea
- sinusitis
- syncope
- urinary incontinence
- urticaria
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- driving or operating machinery
- females
- geriatric
- hepatic disease
- hypotension
- infants
- neonates
- ocular surgery
- orthostatic hypotension
- pregnancy
- priapism
- prostate cancer
- renal disease
- renal failure
- renal impairment
- syncope
Interactions
- Acebutolol
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alpha-blockers
- Ambrisentan
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Avanafil
- Azilsartan
- Azilsartan; Chlorthalidone
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Beta-adrenergic blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Brigatinib
- Brimonidine; Timolol
- Bumetanide
- Cabozantinib
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Capmatinib
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carteolol
- Carvedilol
- Central-acting adrenergic agents
- Ceritinib
- Chloramphenicol
- Chlorothiazide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Clarithromycin
- Clonidine
- Cobicistat
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Cyclosporine
- Daclatasvir
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Diazoxide
- Diltiazem
- Dorzolamide; Timolol
- Doxazosin
- Dronedarone
- Dutasteride; Tamsulosin
- Duvelisib
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esmolol
- Ethacrynic Acid
- Ethanol
- Etravirine
- Fedratinib
- Felodipine
- Fenoldopam
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Glecaprevir; Pibrentasvir
- grapefruit juice
- Guanabenz
- Guanfacine
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Idelalisib
- Iloprost
- Imatinib
- Indapamide
- Indinavir
- Irbesartan
- Isavuconazonium
- Isradipine
- Istradefylline
- Itraconazole
- Ketoconazole
- Labetalol
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Lisinopril
- Loop diuretics
- Lopinavir; Ritonavir
- Losartan
- Mecamylamine
- Methyclothiazide
- Methyldopa
- Metolazone
- Metoprolol
- Mifepristone
- Minoxidil
- Mitotane
- Moexipril
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitroprusside
- Olmesartan
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Penbutolol
- Perindopril
- Perindopril; Amlodipine
- Phenoxybenzamine
- Phentolamine
- Pindolol
- Posaconazole
- Potassium-sparing diuretics
- Prazosin
- Probenecid
- Propranolol
- Quinapril
- Ramipril
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Ritonavir
- Sacubitril; Valsartan
- Sapropterin
- Saquinavir
- Sildenafil
- Simeprevir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Spironolactone
- Tadalafil
- Tamsulosin
- Telaprevir
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Temsirolimus
- Terazosin
- Thiazide diuretics
- Timolol
- Tipranavir
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Treprostinil
- Triamterene
- Tucatinib
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vardenafil
- Vemurafenib
- Verapamil
- Voriconazole
- Zafirlukast
- Zileuton