Teduglutide

What is Teduglutide

Teduglutide is a recombinant glucagon-like peptide-2 (GLP-2) analog.

The drug is used to treat pediatric and adult patients with intestinal failure secondary to short bowel syndrome (SBS) who are dependent on parenteral nutrition.

Brand Name

Gattex

Indications

  • short bowel syndrome

For the treatment of short bowel syndrome in patients who are dependent on parenteral support

Side Effects

  1. abdominal pain
  2. antibody formation
  3. blepharedema
  4. cholangitis
  5. cholecystitis
  6. cholelithiasis
  7. cholestasis
  8. cough
  9. dyspnea
  10. edema
  11. erythema
  12. flatulence
  13. fluid retention
  14. flushing
  15. GI obstruction
  16. heart failure
  17. infection
  18. influenza
  19. injection site reaction
  20. maculopapular rash
  21. nausea
  22. new primary malignancy
  23. pancreatitis
  24. peripheral edema
  25. pruritus
  26. rash
  27. urticaria
  28. vomiting

Monitoring Parameters

  • colonoscopy
  • serum alkaline phosphatase
  • serum amylase
  • serum bilirubin
  • serum creatinine/BUN
  • serum electrolytes
  • serum lipase
  • serum osmolality
  • weight

Contraindications

  • biliary tract disease
  • breast-feeding
  • cardiac disease
  • electrolyte imbalance
  • gallbladder disease
  • GI obstruction
  • heart failure
  • neoplastic disease
  • new primary malignancy
  • pancreatitis
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Alprazolam
  • Amitriptyline; Chlordiazepoxide
  • Benzodiazepines
  • Carbamazepine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Clonazepam
  • Clorazepate
  • Cyclosporine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Digoxin
  • Disopyramide
  • Estazolam
  • Ethosuximide
  • Flecainide
  • Flurazepam
  • Lithium
  • Lorazepam
  • Midazolam
  • Oxazepam
  • Phenytoin
  • Procainamide
  • Quazepam
  • Quinidine
  • Sirolimus
  • Tacrolimus
  • Temazepam
  • Theophylline, Aminophylline
  • Thyroid hormones
  • Triazolam
  • Valproic Acid, Divalproex Sodium
  • Warfarin
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