What is Tazarotene
Tazarotene is a retinoid prodrug of tazarotenic acid for the treatment of psoriasis, acne vulgaris, and photoaging of the skin.
As vitamin A (retinol) derivatives, retinoids are important regulators of cell reproduction and cell proliferation and differentiation; however, unlike vitamin A, retinoids are not converted into rhodopsin, which is needed for night vision. In addition, it should be noted that tazarotene has not demonstrated a mitigating effect on significant signs of chronic sunlight exposure such as coarse or deep wrinkling, tactile roughness, telangiectasia, skin laxity, keratinocytic atypia, melanocytic atypia, or dermal elastosis.
According to the manufacturer of tazarotene cream, the drug does not eliminate or prevent wrinkles, repair sun-damaged skin, reverse photoaging, or restore more youthful or younger skin.
Tazarotene is contraindicated for use during pregnancy; females of childbearing potential should undergo pregnancy testing within 2 weeks of initiating treatment, and use adequate birth control during treatment.
Indications
- acne vulgaris
- facial wrinkles
- photoaging
- psoriasis
For the treatment of plaque psoriasis
Side Effects
- bleeding
- cheilitis
- contact dermatitis
- edema
- erythema
- hypertriglyceridemia
- peripheral edema
- photosensitivity
- pruritus
- rash
- skin discoloration
- skin hyperpigmentation
- skin hypopigmentation
- skin irritation
- urticaria
- xerosis
Monitoring Parameters
- pregnancy testing
- skin cancer screening exam
Contraindications
- accidental exposure
- benzyl alcohol hypersensitivity
- breast-feeding
- children
- contraception requirements
- eczema
- females
- infants
- neonates
- occlusive dressing
- ocular exposure
- pregnancy
- pregnancy testing
- retinoid hypersensitivity
- skin cancer
- skin photosensitivity disorder
- sunburn
- sunlight (UV) exposure
Interactions
- Acetohexamide
- Adapalene; Benzoyl Peroxide
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Atenolol; Chlorthalidone
- Azilsartan; Chlorthalidone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoyl Peroxide
- Benzoyl Peroxide; Clindamycin
- Benzoyl Peroxide; Erythromycin
- Benzoyl Peroxide; Sulfur
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Chlorothiazide
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Ciprofloxacin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dextromethorphan; Promethazine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Fluphenazine
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gemifloxacin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Griseofulvin
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Indapamide
- Levofloxacin
- Meperidine; Promethazine
- Mesoridazine
- Methyclothiazide
- Metolazone
- Moxifloxacin
- Norfloxacin
- Ofloxacin
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Prochlorperazine
- Promethazine
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Tetracyclines
- Thiazide diuretics
- Thiethylperazine
- Thioridazine
- Tolazamide
- Tolbutamide
- Trifluoperazine
