Tazarotene

What is Tazarotene

Tazarotene is a retinoid prodrug of tazarotenic acid for the treatment of psoriasis, acne vulgaris, and photoaging of the skin.

As vitamin A (retinol) derivatives, retinoids are important regulators of cell reproduction and cell proliferation and differentiation; however, unlike vitamin A, retinoids are not converted into rhodopsin, which is needed for night vision. In addition, it should be noted that tazarotene has not demonstrated a mitigating effect on significant signs of chronic sunlight exposure such as coarse or deep wrinkling, tactile roughness, telangiectasia, skin laxity, keratinocytic atypia, melanocytic atypia, or dermal elastosis.

According to the manufacturer of tazarotene cream, the drug does not eliminate or prevent wrinkles, repair sun-damaged skin, reverse photoaging, or restore more youthful or younger skin.

Tazarotene is contraindicated for use during pregnancy; females of childbearing potential should undergo pregnancy testing within 2 weeks of initiating treatment, and use adequate birth control during treatment.

Indications

  • acne vulgaris
  • facial wrinkles
  • photoaging
  • psoriasis

For the treatment of plaque psoriasis

Side Effects

  1. bleeding
  2. cheilitis
  3. contact dermatitis
  4. edema
  5. erythema
  6. hypertriglyceridemia
  7. peripheral edema
  8. photosensitivity
  9. pruritus
  10. rash
  11. skin discoloration
  12. skin hyperpigmentation
  13. skin hypopigmentation
  14. skin irritation
  15. urticaria
  16. xerosis

Monitoring Parameters

  • pregnancy testing
  • skin cancer screening exam

Contraindications

  • accidental exposure
  • benzyl alcohol hypersensitivity
  • breast-feeding
  • children
  • contraception requirements
  • eczema
  • females
  • infants
  • neonates
  • occlusive dressing
  • ocular exposure
  • pregnancy
  • pregnancy testing
  • retinoid hypersensitivity
  • skin cancer
  • skin photosensitivity disorder
  • sunburn
  • sunlight (UV) exposure

Interactions

  • Acetohexamide
  • Adapalene; Benzoyl Peroxide
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Atenolol; Chlorthalidone
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoyl Peroxide
  • Benzoyl Peroxide; Clindamycin
  • Benzoyl Peroxide; Erythromycin
  • Benzoyl Peroxide; Sulfur
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Chlorothiazide
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Ciprofloxacin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dextromethorphan; Promethazine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Fluphenazine
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gemifloxacin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Griseofulvin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Indapamide
  • Levofloxacin
  • Meperidine; Promethazine
  • Mesoridazine
  • Methyclothiazide
  • Metolazone
  • Moxifloxacin
  • Norfloxacin
  • Ofloxacin
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Prochlorperazine
  • Promethazine
  • St. John’s Wort, Hypericum perforatum
  • Sulfonylureas
  • Tetracyclines
  • Thiazide diuretics
  • Thiethylperazine
  • Thioridazine
  • Tolazamide
  • Tolbutamide
  • Trifluoperazine
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top