Tbo Filgrastim

What is Tbo Filgrastim

Tbo- filgrastim is a leukocyte growth factor that binds to cell surface receptors on hematopoietic cells stimulating proliferation, differentiation, commitment, and end cell functional activation.

It is indicated to decrease the duration of neutropenia in patients aged 1 month and older with non-myeloid malignancies receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia.

Acute respiratory distress syndrome, fatal splenic rupture, and glomerulonephritis have occurred with filgrastim products, including tbo-filgrastim.

Brand Name

Granix

Indications

  • chemotherapy-induced neutropenia

For chemotherapy-induced neutropenia prophylaxis to reduce the duration of severe neutropenia in patients with nonmyeloid malignancies receiving myelosuppressive chemotherapy associated with a clinically significant incidence of febrile neutropenia

Side Effects

  1. abdominal pain
  2. acute respiratory distress syndrome (ARDS)
  3. anaphylactoid reactions
  4. angioedema
  5. antibody formation
  6. aortitis
  7. asthenia
  8. azotemia
  9. back pain
  10. bleeding
  11. bone pain
  12. capillary leak syndrome
  13. contact dermatitis
  14. diarrhea
  15. dyspnea
  16. edema
  17. fatigue
  18. fever
  19. glomerulonephritis
  20. headache
  21. hematuria
  22. hemoptysis
  23. hypoalbuminemia
  24. hypotension
  25. leukocytosis
  26. malaise
  27. myalgia
  28. proteinuria
  29. pruritus
  30. rash
  31. sickle-cell crisis
  32. splenic rupture
  33. splenomegaly
  34. thrombocytopenia
  35. urticaria
  36. vasculitis
  37. vomiting

Monitoring Parameters

  • CBC with differential

Contraindications

  • breast-feeding
  • E. coli protein hypersensitivity
  • leukemia
  • leukocytosis
  • myelodysplastic syndrome (MDS)
  • pregnancy
  • radiation therapy
  • sickle cell disease

Interactions

  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alpha interferons
  • Altretamine
  • Antimetabolites
  • Bevacizumab
  • Bexarotene
  • Chlorambucil
  • Cladribine
  • Clofarabine
  • Cyclophosphamide
  • Denileukin Diftitox
  • Docetaxel
  • Estramustine
  • Fludarabine
  • Ibritumomab Tiuxetan
  • Lithium
  • Lomustine, CCNU
  • Mercaptopurine, 6-MP
  • Methotrexate
  • Natural Antineoplastics
  • Nelarabine
  • Paclitaxel
  • Pentostatin
  • Tositumomab
  • Tretinoin, ATRA
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