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What is Tbo Filgrastim
Tbo- filgrastim is a leukocyte growth factor that binds to cell surface receptors on hematopoietic cells stimulating proliferation, differentiation, commitment, and end cell functional activation.
It is indicated to decrease the duration of neutropenia in patients aged 1 month and older with non-myeloid malignancies receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia.
Acute respiratory distress syndrome, fatal splenic rupture, and glomerulonephritis have occurred with filgrastim products, including tbo-filgrastim.
Brand Name
Granix
Indications
- chemotherapy-induced neutropenia
For chemotherapy-induced neutropenia prophylaxis to reduce the duration of severe neutropenia in patients with nonmyeloid malignancies receiving myelosuppressive chemotherapy associated with a clinically significant incidence of febrile neutropenia
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anaphylactoid reactions
- angioedema
- antibody formation
- aortitis
- asthenia
- azotemia
- back pain
- bleeding
- bone pain
- capillary leak syndrome
- contact dermatitis
- diarrhea
- dyspnea
- edema
- fatigue
- fever
- glomerulonephritis
- headache
- hematuria
- hemoptysis
- hypoalbuminemia
- hypotension
- leukocytosis
- malaise
- myalgia
- proteinuria
- pruritus
- rash
- sickle-cell crisis
- splenic rupture
- splenomegaly
- thrombocytopenia
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- CBC with differential
Contraindications
- breast-feeding
- E. coli protein hypersensitivity
- leukemia
- leukocytosis
- myelodysplastic syndrome (MDS)
- pregnancy
- radiation therapy
- sickle cell disease
Interactions
- Aldesleukin, IL-2
- Alemtuzumab
- Alpha interferons
- Altretamine
- Antimetabolites
- Bevacizumab
- Bexarotene
- Chlorambucil
- Cladribine
- Clofarabine
- Cyclophosphamide
- Denileukin Diftitox
- Docetaxel
- Estramustine
- Fludarabine
- Ibritumomab Tiuxetan
- Lithium
- Lomustine, CCNU
- Mercaptopurine, 6-MP
- Methotrexate
- Natural Antineoplastics
- Nelarabine
- Paclitaxel
- Pentostatin
- Tositumomab
- Tretinoin, ATRA
