Stiripentol

What is Stiripentol

Stiripentol is a structurally unique oral antiepileptic indicated for the treatment of seizures associated with Dravet syndrome in patients 2 years and older who are also taking clobazam.

There are no clinical data to support stiripentol monotherapy in Dravet syndrome; trials have only documented efficacy when it is combined with clobazam and/or valproate

Brand Name

DIACOMIT

Indications

  • Dravet syndrome

Side Effects

  1. agitation
  2. anorexia
  3. ataxia
  4. depression
  5. drowsiness
  6. dysarthria
  7. fatigue
  8. fever
  9. hypersalivation
  10. hypotonia
  11. infection
  12. insomnia
  13. nausea
  14. neutropenia
  15. pharyngitis
  16. suicidal ideation
  17. thrombocytopenia
  18. tremor
  19. vomiting
  20. weight gain
  21. weight loss

Monitoring Parameters

  • CBC
  • weight

Contraindications

  • abrupt discontinuation
  • breast-feeding
  • children
  • depression
  • driving or operating machinery
  • growth inhibition
  • hepatic disease
  • neutropenia
  • phenylketonuria
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • suicidal ideation
  • thrombocytopenia

Interactions

No information is available regarding drug interactions associated with Stiripentol