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What is Tazemetostat
Tazemetostat is an EZH2 histone methyltransferase inhibitor indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.
Tazemetostat therapy increases the risk of developing a new primary malignancy
Brand Name
TAZVERIK
Indications
- soft-tissue sarcoma
Side Effects
- abdominal pain
- anemia
- anorexia
- arthralgia
- asthenia
- back pain
- bleeding
- bone pain
- constipation
- cough
- diarrhea
- dyspnea
- elevated hepatic enzymes
- fatigue
- headache
- hemoptysis
- hyperglycemia
- hyperkalemia
- hypertriglyceridemia
- hypoalbuminemia
- hypocalcemia
- hypoglycemia
- hypokalemia
- hyponatremia
- hypophosphatemia
- infection
- intracranial bleeding
- lymphopenia
- musculoskeletal pain
- myalgia
- nausea
- nephrotoxicity
- neutropenia
- new primary malignancy
- pleural effusion
- prolonged bleeding time
- vomiting
- weight loss
Monitoring Parameters
- CBC with differential
- pregnancy testing
Contraindications
- anemia
- breast-feeding
- contraception requirements
- male-mediated teratogenicity
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- reproductive risk
- thrombocytopenia
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Tramadol
- Alfentanil
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Carisoprodol; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Butabarbital
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Etravirine
- Fedratinib
- Fentanyl
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ketoconazole
- Lefamulin
- Letermovir
- Leuprolide; Norethindrone
- Levonorgestrel
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Medroxyprogesterone
- Mefloquine
- Mestranol; Norethindrone
- Methadone
- Methohexital
- Midazolam
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nanoparticle Albumin-Bound Paclitaxel
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Nimodipine
- Nisoldipine
- Norethindrone
- Norgestrel
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Progesterone
- Progestins
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Saquinavir
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Sildenafil
- Sirolimus
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tacrolimus
- Telithromycin
- Tipranavir
- Tramadol
- Trandolapril; Verapamil
- Tucatinib
- Ubrogepant
- Verapamil
- Voriconazole
- Warfarin