Tazemetostat

What is Tazemetostat

Tazemetostat is an EZH2 histone methyltransferase inhibitor indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.

Tazemetostat therapy increases the risk of developing a new primary malignancy

Brand Name

TAZVERIK

Indications

  • soft-tissue sarcoma

Side Effects

  1. abdominal pain
  2. anemia
  3. anorexia
  4. arthralgia
  5. asthenia
  6. back pain
  7. bleeding
  8. bone pain
  9. constipation
  10. cough
  11. diarrhea
  12. dyspnea
  13. elevated hepatic enzymes
  14. fatigue
  15. headache
  16. hemoptysis
  17. hyperglycemia
  18. hyperkalemia
  19. hypertriglyceridemia
  20. hypoalbuminemia
  21. hypocalcemia
  22. hypoglycemia
  23. hypokalemia
  24. hyponatremia
  25. hypophosphatemia
  26. infection
  27. intracranial bleeding
  28. lymphopenia
  29. musculoskeletal pain
  30. myalgia
  31. nausea
  32. nephrotoxicity
  33. neutropenia
  34. new primary malignancy
  35. pleural effusion
  36. prolonged bleeding time
  37. vomiting
  38. weight loss

Monitoring Parameters

  • CBC with differential
  • pregnancy testing

Contraindications

  • anemia
  • breast-feeding
  • contraception requirements
  • male-mediated teratogenicity
  • neutropenia
  • new primary malignancy
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • thrombocytopenia

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Tramadol
  • Alfentanil
  • Amiodarone
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Bosentan
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Butabarbital
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Cenobamate
  • Ceritinib
  • Chloramphenicol
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Ciprofloxacin
  • Clarithromycin
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexamethasone
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dronedarone
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etonogestrel
  • Etravirine
  • Fedratinib
  • Fentanyl
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxyprogesterone
  • Idelalisib
  • Imatinib
  • Indinavir
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ketoconazole
  • Lefamulin
  • Letermovir
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Medroxyprogesterone
  • Mefloquine
  • Mestranol; Norethindrone
  • Methadone
  • Methohexital
  • Midazolam
  • Mifepristone
  • Mitotane
  • Modafinil
  • Nafcillin
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nilotinib
  • Nimodipine
  • Nisoldipine
  • Norethindrone
  • Norgestrel
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Progesterone
  • Progestins
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Ritonavir
  • Saquinavir
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Sildenafil
  • Sirolimus
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Tacrolimus
  • Telithromycin
  • Tipranavir
  • Tramadol
  • Trandolapril; Verapamil
  • Tucatinib
  • Ubrogepant
  • Verapamil
  • Voriconazole
  • Warfarin
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