Reboxetine

What is Reboxetine

Reboxetine is an antidepressant with a unique mechanism of action; the drug is the first in a new class of medications known as selective norepinephrine reuptake inhibitors (SNRIs).

Reboxetine has been studied for 20 years and is used in 18 countries outside the US. Reboxetine is effective for moderate to severe depression and dysthymia.

Indications

  • depression

Side Effects

  • anxiety
  • constipation
  • diaphoresis
  • headache
  • hypertension
  • impotence (erectile dysfunction)
  • insomnia
  • libido decrease
  • nausea
  • orthostatic hypotension
  • SIADH
  • sinus tachycardia
  • tremor
  • urinary retention
  • vertigo
  • vomiting
  • xerostomia

Monitoring Parameters

  • LFTs

Contraindications

  • abrupt discontinuation
  • bipolar disorder
  • bladder obstruction
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • children
  • dehydration
  • geriatric
  • GI obstruction
  • glaucoma
  • hepatic disease
  • hypertension
  • hyponatremia
  • hypotension
  • hypovolemia
  • ileus
  • mania
  • MAOI therapy
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • seizure disorder
  • suicidal ideation
  • urinary retention

Interactions

No information is available regarding drug interactions associated with Reboxetine

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