Sevelamer

What is Sevelamer

Sevelamer is an oral phosphate binder indicated for the control of serum phosphorus in patients with chronic kidney disease on dialysis. 

Brand Name

  • RenaGel
  • Renvela

Indications & Dosage

  • hyperphosphatemia

For the treatment of hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis

Side Effects

  • abdominal pain
  • bowel necrosis
  • colitis
  • constipation
  • diarrhea
  • dyspepsia
  • dysphagia
  • flatulence
  • folate deficiency
  • GI bleeding
  • GI obstruction
  • GI perforation
  • hyperkalemia
  • ileus
  • infection
  • metabolic acidosis
  • nausea
  • pruritus
  • rash
  • vitamin D deficiency
  • vitamin K deficiency
  • vomiting

Monitoring Parameters

  • serum 25(OH)hydroxyvitamin D concentrations
  • serum bicarbonate
  • serum chloride
  • serum folate concentration
  • serum phosphate

Contraindications

  • breast-feeding
  • constipation
  • dysphagia
  • GI obstruction
  • pregnancy
  • surgery

Interactions

  • Ciprofloxacin
  • Clonazepam
  • Cyclosporine
  • Delafloxacin
  • Dichlorphenamide
  • Erdafitinib
  • Ethosuximide
  • Gemifloxacin
  • Ibritumomab Tiuxetan
  • Levofloxacin
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Liothyronine
  • Lithium
  • Moxifloxacin
  • Mycophenolate
  • Norfloxacin
  • Ofloxacin
  • Phenytoin
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Procainamide
  • Tacrolimus
  • Theophylline, Aminophylline
  • Thyroid hormones
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