Tecovirimat

What is Tecovirimat

Tecovirimat is an antiviral drug, and the first medication approved for treatment of human smallpox disease caused by the variola virus.

Tecovirimat targets a virus specific protein (i.e., p37 envelope wrapping protein), and thus, possesses selective antiviral activity against orthopoxviruses, including variola virus.

By blocking the actions of viral p37 protein, tecovirimat inhibits production of extracellular virions; thereby preventing the spread of infection until the body’s immune system can clear the virus.

Efficacy data has been extrapolated from animal studies, as adequate and well-controlled studies in humans was not feasible. The drug is indicated for use in adults and pediatric patients weighing at least 13 kg

Brand Name

TPOXX

Indications

  • variola virus (smallpox)
  • variola virus (smallpox) infection

Side Effects

  1. abdominal pain
  2. arthralgia
  3. chills
  4. depression
  5. diarrhea
  6. dysgeusia
  7. dyspepsia
  8. dysphoria
  9. edema
  10. EEG changes
  11. eructation
  12. erythema
  13. fever
  14. headache
  15. irritability
  16. malaise
  17. migraine
  18. nausea
  19. paresthesias
  20. pruritus
  21. purpura
  22. rash
  23. sinus tachycardia
  24. vomiting
  25. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • chemotherapy
  • corticosteroid therapy
  • immunosuppression
  • pregnancy
  • radiation therapy

Interactions

No information is available regarding drug interactions associated with Tecovirimat 

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