Siltuximab

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What is Siltuximab

Siltuximab is an interleukin-6 antagonist indicated for the treatment of adult patients with multicentric Castleman disease who are human immunodeficiency virus-negative and human herpesvirus-8-negative.

Monitor patients for signs and symptoms of infection; do not start siltuximab in patients with a severe active infection.

Severe infusion-related reactions may occur; therefore, administer siltuximab in a setting that provides resuscitation equipment, medication, and personnel trained to provide resuscitation.

Brand Name

Sylvant

Indications & Dosage

  • coronavirus disease 2019 (COVID-19)
  • multicentric Castleman disease
  • severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection

INVESTIGATIONAL USE: For adjunctive use in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection†, the virus that causes coronavirus disease 2019 (COVID-19)

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. antibody formation
  4. back pain
  5. chest pain (unspecified)
  6. constipation
  7. cytokine release syndrome
  8. diarrhea
  9. dizziness
  10. edema
  11. edema
  12. erythema
  13. flushing
  14. gastroesophageal reflux
  15. GI perforation
  16. headache
  17. hypercholesterolemia
  18. hypertension
  19. hypertriglyceridemia
  20. hyperuricemia
  21. hyperuricemia
  22. hypotension
  23. hypotension
  24. infection
  25. infection
  26. infusion-related reactions
  27. infusion-related reactions
  28. maculopapular rash
  29. maculopapular rash
  30. nausea
  31. nephrotoxicity
  32. neutropenia
  33. oral ulceration
  34. palpitations
  35. pharyngitis
  36. pruritus
  37. psoriasis
  38. rash
  39. rash
  40. skin hyperpigmentation
  41. thrombocytopenia
  42. thrombocytopenia
  43. vomiting
  44. weight gain
  45. weight gain
  46. xerosis

Monitoring Parameters

  • CBC with differential

Contraindications

  • breast-feeding
  • contraception requirements
  • diverticulitis
  • GI perforation
  • infants
  • infection
  • infusion-related reactions
  • neonates
  • neutropenia
  • peptic ulcer disease
  • pregnancy
  • reproductive risk
  • thrombocytopenia
  • vaccination

Interactions

  • Alfentanil
  • Amlodipine; Atorvastatin
  • Apixaban
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Caffeine; Ergotamine
  • Canakinumab
  • Carbamazepine
  • Cisapride
  • Clozapine
  • Cyclosporine
  • Dextromethorphan; Quinidine
  • Dienogest; Estradiol valerate
  • Dihydroergotamine
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Ergotamine
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Everolimus
  • Ezetimibe; Simvastatin
  • Fentanyl
  • Fosphenytoin
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Live Vaccines
  • Lovastatin
  • Lovastatin; Niacin
  • Mestranol; Norethindrone
  • Niacin; Simvastatin
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Phenytoin
  • Pimozide
  • Quinidine
  • Rivaroxaban
  • Segesterone Acetate; Ethinyl Estradiol
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • Tacrolimus
  • Theophylline, Aminophylline
  • Thioridazine
  • Tizanidine
  • Warfarin

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