Roflumilast

What is Roflumilast

Roflumilast is a phosphodiesterase-4 (PDE4) inhibitor. The PDE4 enzyme is preferentially expressed in pro-inflammatory cells; inhibition results in intracellular accumulation of cyclic-AMP, a process which appears to down-regulate inflammation.

The drug is used to reduce chronic obstructive pulmonary disease (COPD) exacerbations in adults with severe COPD associated with bronchitis and a history of exacerbations. 

Brand Name

DALIRESP

Indications

  • chronic bronchitis
  • chronic obstructive pulmonary disease (COPD)

For the prevention of COPD exacerbations in chronic bronchitis patients with severe chronic obstructive pulmonary disease (COPD) associated a history of COPD exacerbations

Side Effects

  1. abdominal pain
  2. angioedema
  3. anorexia
  4. anxiety
  5. back pain
  6. depression
  7. diarrhea
  8. dizziness
  9. dyspepsia
  10. gastritis
  11. gynecomastia
  12. headache
  13. infection
  14. influenza
  15. insomnia
  16. muscle cramps
  17. nausea
  18. rash
  19. rhinitis
  20. sinusitis
  21. suicidal ideation
  22. tremor
  23. urticaria
  24. vomiting
  25. weight loss

Monitoring Parameters

  • pulmonary function tests (PFTs)
  • weight

Contraindications

  • acute bronchospasm
  • anxiety
  • breast-feeding
  • children
  • depression
  • hepatic disease
  • infants
  • insomnia
  • labor
  • neonates
  • obstetric delivery
  • pregnancy
  • suicidal ideation

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Amobarbital
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Bosentan
  • Butabarbital
  • Carbamazepine
  • Ceritinib
  • Cimetidine
  • Cobicistat
  • Crizotinib
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexamethasone
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etravirine
  • Fedratinib
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Indinavir
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Lefamulin
  • Letermovir
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Mephobarbital
  • Mestranol; Norethindrone
  • Methohexital
  • Mitotane
  • Modafinil
  • Nevirapine
  • Norethindrone
  • Norgestrel
  • Obeticholic Acid
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oral Contraceptives
  • Pentobarbital
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Riociguat
  • Ritonavir
  • Rucaparib
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • St. John’s Wort, Hypericum perforatum
  • Telotristat Ethyl
  • Theophylline, Aminophylline
  • Thiopental
  • Tipranavir
  • Tucatinib
  • Voriconazole
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