What's on this Page
What is Roflumilast
Roflumilast is a phosphodiesterase-4 (PDE4) inhibitor. The PDE4 enzyme is preferentially expressed in pro-inflammatory cells; inhibition results in intracellular accumulation of cyclic-AMP, a process which appears to down-regulate inflammation.
The drug is used to reduce chronic obstructive pulmonary disease (COPD) exacerbations in adults with severe COPD associated with bronchitis and a history of exacerbations.
Brand Name
DALIRESP
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
For the prevention of COPD exacerbations in chronic bronchitis patients with severe chronic obstructive pulmonary disease (COPD) associated a history of COPD exacerbations
Side Effects
- abdominal pain
- angioedema
- anorexia
- anxiety
- back pain
- depression
- diarrhea
- dizziness
- dyspepsia
- gastritis
- gynecomastia
- headache
- infection
- influenza
- insomnia
- muscle cramps
- nausea
- rash
- rhinitis
- sinusitis
- suicidal ideation
- tremor
- urticaria
- vomiting
- weight loss
Monitoring Parameters
- pulmonary function tests (PFTs)
- weight
Contraindications
- acute bronchospasm
- anxiety
- breast-feeding
- children
- depression
- hepatic disease
- infants
- insomnia
- labor
- neonates
- obstetric delivery
- pregnancy
- suicidal ideation
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Amobarbital
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Butabarbital
- Carbamazepine
- Ceritinib
- Cimetidine
- Cobicistat
- Crizotinib
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etravirine
- Fedratinib
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lefamulin
- Letermovir
- Leuprolide; Norethindrone
- Levonorgestrel
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mephobarbital
- Mestranol; Norethindrone
- Methohexital
- Mitotane
- Modafinil
- Nevirapine
- Norethindrone
- Norgestrel
- Obeticholic Acid
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oral Contraceptives
- Pentobarbital
- Phenobarbital
- Phenytoin
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Riociguat
- Ritonavir
- Rucaparib
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- St. John’s Wort, Hypericum perforatum
- Telotristat Ethyl
- Theophylline, Aminophylline
- Thiopental
- Tipranavir
- Tucatinib
- Voriconazole