Stavudine d4T

What is Stavudine d4T

Stavudine d4T is an oral antiretroviral nucleoside reverse transcriptase inhibitor (NRTI). It is a synthetic thymidine nucleoside analog used in combination with other agents to treat HIV-infected patients.

Stavudine is indicated as part of combination therapy for the treatment of HIV infection; it is not recommended to be given as monotherapy.

Concurrent administration of stavudine and didanosine is contraindicated due to the potential for toxicity; concurrent treatment with zidovudine should also be avoided because of the potential for virologic antagonism.

Brand Names

  • Zerit
  • Zerit XR

Indications

  • human immunodeficiency virus (HIV)
  • human immunodeficiency virus (HIV) infection

Side Effects

  1. abdominal pain
  2. anemia
  3. anorexia
  4. chills
  5. diabetes mellitus
  6. diarrhea
  7. dyspnea
  8. elevated hepatic enzymes
  9. fatigue
  10. fever
  11. Guillain-Barre syndrome
  12. headache
  13. hepatic failure
  14. hepatitis
  15. hepatomegaly
  16. hepatotoxicity
  17. hyperamylasemia
  18. hyperbilirubinemia
  19. hyperglycemia
  20. insomnia
  21. lactic acidosis
  22. leukopenia
  23. lipodystrophy
  24. macrocytosis
  25. myalgia
  26. nausea
  27. neutropenia
  28. pancreatitis
  29. peripheral neuropathy
  30. rash
  31. steatosis
  32. tachypnea
  33. thrombocytopenia
  34. vomiting
  35. weakness
  36. weight loss

Monitoring Parameters

  • blood glucose
  • CBC with differential
  • CD4+ T cell count
  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • platelet count
  • pregnancy testing
  • serum amylase
  • serum bilirubin (total and direct)
  • serum cholesterol
  • serum creatinine
  • serum lipase
  • serum lipid profile
  • urinalysis

Contraindications

  • alcoholism
  • autoimmune disease
  • breast-feeding
  • dialysis
  • females
  • geriatric
  • Graves’ disease
  • Guillain-Barre syndrome
  • hepatic disease
  • hepatitis B and HIV coinfection
  • hepatitis C and HIV coinfection
  • hepatotoxicity or lactic acidosis
  • human immunodeficiency virus (HIV) infection resistance
  • immune reconstitution syndrome
  • neuromuscular disease
  • obesity
  • pancreatitis
  • peripheral neuropathy
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Adefovir
  • Bortezomib
  • Colchicine; Probenecid
  • Didanosine, ddI
  • Doxorubicin
  • Echinacea
  • food
  • Hydroxyurea
  • Interferon Alfa-2b; Ribavirin
  • Interferons
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Methadone
  • Orlistat
  • Probenecid
  • Ribavirin
  • Zalcitabine, ddC
  • Zidovudine, ZDV
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