Urofollitropin

What is Urofollitropin

Urofollitropin is a parenteral, human derived urinary gonadotropin formulation used in infertility treatments. The key differences in human-derived FSH (i.e., urofollitropin) and genetically engineered FSH (i.e., r-FSH) are product sources and cost.

Urofollitropin treatments are highly purified follitropins extracted from the urine of postmenopausal women. Urofollitropin contains primarily follicle stimulating hormone (FSH). 

Brand Name

Bravelle

Indications

  • hypogonadism
  • infertility
  • oligospermia

Side Effects

  • abdominal pain
  • acne vulgaris
  • acute respiratory distress syndrome (ARDS)
  • alopecia
  • anaphylactoid reactions
  • anasarca
  • angioedema
  • ascites
  • chills
  • constipation
  • dehydration
  • depression
  • diarrhea
  • dizziness
  • dyspepsia
  • dyspnea
  • ectopic pregnancy
  • emotional lability
  • exfoliative dermatitis
  • fever
  • flatulence
  • gynecomastia
  • headache
  • hot flashes
  • hypertension
  • hypoalbuminemia
  • hypotension
  • hypovolemia
  • injection site reaction
  • laryngeal edema
  • leukorrhea
  • malaise
  • mastalgia
  • menstrual irregularity
  • musculoskeletal pain
  • nausea
  • new primary malignancy
  • oliguria
  • ovarian enlargement
  • ovarian hyperstimulation syndrome (OHSS)
  • pelvic pain
  • pericardial effusion
  • phlebitis
  • pleural effusion
  • pruritus
  • pulmonary edema
  • pulmonary embolism
  • rash
  • sinusitis
  • stroke
  • thromboembolism
  • thrombosis
  • urticaria
  • uterine contractions
  • vaginal bleeding
  • vaginal discharge
  • vomiting
  • weight gain
  • xerosis

Monitoring Parameters

  • blood pressure
  • pelvic exam
  • pelvic ultrasound
  • pregnancy testing
  • serum estradiol concentrations
  • serum gonadotropin concentrations
  • weight

Contraindications

  • adrenal insufficiency
  • ascites
  • asthma
  • breast-feeding
  • children
  • driving or operating machinery
  • dysfunctional uterine bleeding
  • endometriosis
  • geriatric
  • infertility
  • obesity
  • ovarian cyst
  • ovarian failure
  • pituitary adenoma
  • polycystic ovary syndrome
  • pregnancy
  • testicular failure
  • thromboembolic disease
  • thrombophlebitis
  • thyroid disease
  • tobacco smoking
  • uterine leiomyomata
  • vaginal bleeding

Interactions

There are no drug interactions associated with Urofollitropin, FSH products.