Sinecatechins

What is Sinecatechins

Sinecatechins 15% ointment is a topical agent for the treatment of external genital and perianal warts (i.e. condylomata acuminata).

Sinecatechins ointment is a botanical drug product made from green tea leaves (Camellia sinensis (L.) O Kuntze) extract. Green tea catechins constitute 85—95% of the drug substance, with more than 55% being epigallocatechin gallate (EGCG). Like podofilox and imiquimod, sinecatechins ointment can be self-administered by the patient, whereas other treatments for condyloma acuminata (e.g., intralesional interferon alfa, podophyllum resin, trichloroacetic acid) must be administered by a health care provider.

Sinecatechins ointment, like other currently available therapies for genital and perianal warts, does not eradicate human papilloma virus (HPV) infection, the virus typically responsible for causing condylomata acuminata. 

Brand Name

Veregen

Indications & Dosage

  • condylomata acuminata

For the treatment of external genital and perianal warts (Condylomata acuminata)

NOTE: Sinecatechins ointment has not been evaluated for the treatment of urethral, intra-vaginal, cervical, rectal, or intra-anal human papilloma viral disease and is not recommended for these conditions.42880

NOTE: Sinecatechins ointment has not been evaluated for treatment beyond 16 weeks, for multiple treatment courses, or for use in immunocompromised patients.

Side Effects

  1. bleeding
  2. cervical dysplasia
  3. contact dermatitis
  4. dysuria
  5. edema
  6. erythema
  7. hyperesthesia
  8. infection
  9. lymphadenopathy
  10. pelvic pain
  11. phimosis
  12. pruritus
  13. rash
  14. skin discoloration
  15. skin erosion
  16. skin irritation
  17. skin necrosis
  18. skin ulcer
  19. superinfection
  20. vesicular rash

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • breast-feeding
  • children
  • contraceptive devices
  • geriatric
  • immunosuppression
  • infants
  • neonates
  • occlusive dressing
  • ocular exposure
  • pregnancy
  • sunlight (UV) exposure
  • vaginal administration
  • viral infection

Interactions

There are no drug interactions associated with Sinecatechins products.

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