Selinexor

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What is Selinexor

Selinexor is a nuclear export inhibitor.

It is indicated in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least 4 prior therapies and have refractory disease to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody.

The FDA has granted selinexor accelerated approval and fast track status for this indication; further study is required to verify clinical benefit.

Brand Name

XPOVIO

Indications & Dosage

  • multiple myeloma

For the treatment of multiple myeloma

NOTE: The FDA has designated selinexor as an orphan drug for the treatment of multiple myeloma.

for the treatment of multiple myeloma in patients who have received at least 4 prior therapies and who are refractory to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody, in combination with dexamethasone

Side Effects

  1. anemia
  2. anemia
  3. anorexia
  4. anorexia
  5. asthenia
  6. asthenia
  7. bleeding
  8. blurred vision
  9. blurred vision
  10. confusion
  11. constipation
  12. constipation
  13. cough
  14. dehydration
  15. dehydration
  16. delirium
  17. diarrhea
  18. diarrhea
  19. dizziness
  20. dysgeusia
  21. dyspnea
  22. dyspnea
  23. epistaxis
  24. epistaxis
  25. fatigue
  26. fatigue
  27. fever
  28. fever
  29. headache
  30. hyperglycemia
  31. hyperglycemia
  32. hypokalemia
  33. hypokalemia
  34. hyponatremia
  35. hyponatremia
  36. infection
  37. infection
  38. influenza
  39. insomnia
  40. insomnia
  41. leukopenia
  42. leukopenia
  43. lymphopenia
  44. lymphopenia
  45. nausea
  46. nausea
  47. nephrotoxicity
  48. neurotoxicity
  49. neurotoxicity
  50. neutropenia
  51. neutropenia
  52. pharyngitis
  53. rhinitis
  54. syncope
  55. thrombocytopenia
  56. thrombocytopenia
  57. vomiting
  58. vomiting
  59. weight loss
  60. weight loss

Monitoring Parameters

  • CBC with differential
  • pregnancy testing
  • serum electrolytes
  • weight

Contraindications

  • anemia
  • bleeding
  • breast-feeding
  • contraception requirements
  • dehydration
  • diarrhea
  • driving or operating machinery
  • electrolyte imbalance
  • geriatric
  • hyponatremia
  • infection
  • infertility
  • male-mediated teratogenicity
  • nausea/vomiting
  • neurotoxicity
  • neutropenia
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • thrombocytopenia

Interactions

There are no drug interactions associated with Selinexor products.

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