Siponimod

What is Siponimod

Siponimod is an oral sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Brand Name

MAYZENT

Indications & Dosage

• multiple sclerosis

Side Effects

• asthenia
• AV block
• bradycardia
• diarrhea
• dizziness
• dyspnea
• elevated hepatic enzymes
• encephalopathy
• fluid retention
• headache
• hypertension
• infection
• lymphopenia
• macular edema
• multiple sclerosis exacerbation
• myocardial infarction
• nausea
• new primary malignancy
• peripheral edema
• progressive multifocal leukoencephalopathy
• pulmonary embolism
• seizures
• sinusitis
• stroke
• tremor

Monitoring Parameters

• blood pressure
• CBC
• ECG
• LFTs
• ophthalmologic exam
• serum bilirubin
• skin cancer screening exam

Contraindications

• acquired immunodeficiency syndrome (AIDS)
• alcoholism
• angina
• asthma
• AV block
• bradycardia
• breast-feeding
• cardiac arrest
• cardiac arrhythmias
• cardiac disease
• cerebrovascular disease
• chemotherapy
• chronic obstructive pulmonary disease (COPD)
• contraception requirements
• coronary artery disease
• corticosteroid therapy
• diabetes mellitus
• encephalopathy
• females
• fungal infection
• geriatric
• heart failure
• hepatic disease
• herpes infection
• human immunodeficiency virus (HIV) infection
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• immunosuppression
• infection
• leukemia
• long QT syndrome
• lymphoma
• malnutrition
• multiple sclerosis exacerbation
• myocardial infarction
• pregnancy
• progressive multifocal leukoencephalopathy
• pulmonary disease
• QT prolongation
• reproductive risk
• respiratory insufficiency
• sick sinus syndrome
• sleep apnea
• stroke
• syncope
• thyroid disease
• uveitis
• vaccination
• viral infection
• visual disturbance

Interactions

• Acebutolol
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Aclidinium; Formoterol
• Albuterol
• Albuterol; Ipratropium
• Alemtuzumab
• Alfuzosin
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Anthrax Vaccine
• Apalutamide
• Apomorphine
• Aprepitant, Fosaprepitant
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azithromycin
• Bacillus Calmette-Guerin Vaccine, BCG
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Bendroflumethiazide; Nadolol
• Beta-adrenergic blockers
• Betamethasone
• Betaxolol
• Bexarotene
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Brimonidine; Timolol
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Carbamazepine
• Carteolol
• Carvedilol
• Cenobamate
• Ceritinib
• Chloramphenicol
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clozapine
• Cobicistat
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Conivaptan
• Cortisone
• Crizotinib
• Cyclosporine
• Dabrafenib
• Danazol
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dasatinib
• Deflazacort
• Degarelix
• Delavirdine
• Desflurane
• Desipramine
• Deutetrabenazine
• Dexamethasone
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Digoxin
• Diltiazem
• Diphtheria Toxoid, Tetanus Toxoid, Acellular Pertussis Vaccine, DTaP; Haemophilus influenzae type b Conjugate Vaccine; Inactivated Poliovirus Vaccine, IPV
• Diphtheria Toxoid, Tetanus Toxoid, Acellular Pertussis Vaccine, DTaP; Hepatitis B Vaccine, Recombinant; Inactivated Poliovirus Vaccine, IPV
• Diphtheria Toxoid, Tetanus Toxoid, Acellular Pertussis Vaccine, DTaP; Inactivated Poliovirus Vaccine, IPV
• Diphtheria Toxoid; Tetanus Toxoid Adsorbed, DT, Td
• Diphtheria/Tetanus Toxoids; Pertussis Vaccine
• Diphtheria/Tetanus Toxoids; Pertussis Vaccine; Haemophilus influenzae type b Conjugate Vaccine
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Dorzolamide; Timolol
• Doxepin
• Dronedarone
• Droperidol
• Duvelisib
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Encorafenib
• Enflurane
• Entrectinib
• Enzalutamide
• Eribulin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Eslicarbazepine
• Esmolol
• Etravirine
• Ezogabine
• Fedratinib
• Fingolimod
• Flecainide
• Fluconazole
• Fluorouracil, 5-FU
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosamprenavir
• Foscarnet
• Fosphenytoin
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gilteritinib
• Glasdegib
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• grapefruit juice
• Haemophilus influenzae type b Conjugate Vaccine
• Haemophilus influenzae type b Conjugate Vaccine; Hepatitis B Vaccine, Recombinant
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Hepatitis A Vaccine, Inactivated
• Hepatitis A Vaccine, Inactivated; Hepatitis B Vaccine, Recombinant
• Hepatitis B Vaccine, Recombinant
• Histrelin
• Human Papillomavirus 9-Valent Vaccine
• Human Papillomavirus Bivalent Vaccine
• Human Papillomavirus Quadrivalent Vaccine
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrocortisone
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Idelalisib
• Iloperidone
• Imatinib
• Imipramine
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indinavir
• Influenza Virus Vaccine
• Inotuzumab Ozogamicin
• Intranasal Influenza Vaccine
• Isavuconazonium
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Itraconazole
• Ivabradine
• Ivosidenib
• Japanese Encephalitis Virus Vaccine
• Ketoconazole
• Labetalol
• Lapatinib
• Lefamulin
• Lenvatinib
• Letermovir
• Leuprolide
• Leuprolide; Norethindrone
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levofloxacin
• Lithium
• Live Vaccines
• Lofexidine
• Long-acting beta-agonists
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorlatinib
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Lyme Disease Vaccine
• Macimorelin
• Maprotiline
• Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
• Measles/Mumps/Rubella Vaccines, MMR
• Mefloquine
• Meningococcal Conjugate Vaccine (MCV4)
• Meningococcal Group B Vaccine (3 strain)
• Meningococcal Group B Vaccine (4 strain)
• Meningococcal Haemophilus influenzae type b Conjugate Vaccine
• Meningococcal Polysaccharide Vaccine (MPSV4)
• Meperidine; Promethazine
• Metaproterenol
• Methadone
• Methylprednisolone
• Metoprolol
• Metronidazole
• Midostaurin
• Mifepristone
• Mirtazapine
• Mitotane
• Modafinil
• Moxifloxacin
• Nadolol
• Nafcillin
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nelfinavir
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nilotinib
• Non-Live Vaccines
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Olodaterol
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Paliperidone
• Panobinostat
• Pasireotide
• Pazopanib
• Penbutolol
• Pentamidine
• Pentobarbital
• Perphenazine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phenylephrine; Promethazine
• Phenytoin
• Pimavanserin
• Pimozide
• Pindolol
• Pirbuterol
• Pitolisant
• Pneumococcal Vaccine, Polyvalent
• Poliovirus Vaccine, Inactivated, IPV
• Posaconazole
• Prednisolone
• Prednisone
• Primaquine
• Primidone
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Propranolol
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Rabies Vaccine
• Ranolazine
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifapentine
• Rifaximin
• Rilpivirine
• Risperidone
• Ritonavir
• Romidepsin
• Rotavirus Vaccine
• Rubella Virus Vaccine Live
• Salmeterol
• Saquinavir
• Secobarbital
• Selpercatinib
• Sertraline
• Sevoflurane
• Short-acting beta-agonists
• Smallpox and Monkeypox Vaccine, Live, Nonreplicating
• Smallpox Vaccine, Vaccinia Vaccine
• Solifenacin
• Sorafenib
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
• Sunitinib
• Tacrolimus
• Tamoxifen
• Telavancin
• Telithromycin
• Terbutaline
• Tetanus Toxoid
• Tetrabenazine
• Thioridazine
• Timolol
• Tiotropium; Olodaterol
• Tipranavir
• Tolterodine
• Toremifene
• Trandolapril; Verapamil
• Trazodone
• Triamcinolone
• Tricyclic antidepressants
• Trifluoperazine
• Trimipramine
• Triptorelin
• Tucatinib
• Typhoid Vaccine
• Umeclidinium; Vilanterol
• Vandetanib
• Vardenafil
• Varicella-Zoster Virus Vaccine, Live
• Vemurafenib
• Venlafaxine
• Verapamil
• Voriconazole
• Vorinostat
• Yellow Fever Vaccine, Live
• Ziprasidone