What is Siponimod
Siponimod is an oral sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
Brand Name
MAYZENT
Indications & Dosage
- multiple sclerosis
Side Effects
- asthenia
- AV block
- bradycardia
- diarrhea
- dizziness
- dyspnea
- elevated hepatic enzymes
- encephalopathy
- fluid retention
- headache
- hypertension
- infection
- lymphopenia
- macular edema
- multiple sclerosis exacerbation
- myocardial infarction
- nausea
- new primary malignancy
- peripheral edema
- progressive multifocal leukoencephalopathy
- pulmonary embolism
- seizures
- sinusitis
- stroke
- tremor
Monitoring Parameters
- blood pressure
- CBC
- ECG
- LFTs
- ophthalmologic exam
- serum bilirubin
- skin cancer screening exam
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- alcoholism
- angina
- asthma
- AV block
- bradycardia
- breast-feeding
- cardiac arrest
- cardiac arrhythmias
- cardiac disease
- cerebrovascular disease
- chemotherapy
- chronic obstructive pulmonary disease (COPD)
- contraception requirements
- coronary artery disease
- corticosteroid therapy
- diabetes mellitus
- encephalopathy
- females
- fungal infection
- geriatric
- heart failure
- hepatic disease
- herpes infection
- human immunodeficiency virus (HIV) infection
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- immunosuppression
- infection
- leukemia
- long QT syndrome
- lymphoma
- malnutrition
- multiple sclerosis exacerbation
- myocardial infarction
- pregnancy
- progressive multifocal leukoencephalopathy
- pulmonary disease
- QT prolongation
- reproductive risk
- respiratory insufficiency
- sick sinus syndrome
- sleep apnea
- stroke
- syncope
- thyroid disease
- uveitis
- vaccination
- viral infection
- visual disturbance
Interactions
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alemtuzumab
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Anthrax Vaccine
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bacillus Calmette-Guerin Vaccine, BCG
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Beta-adrenergic blockers
- Betamethasone
- Betaxolol
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Brimonidine; Timolol
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Carbamazepine
- Carteolol
- Carvedilol
- Cenobamate
- Ceritinib
- Chloramphenicol
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Cortisone
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Deutetrabenazine
- Dexamethasone
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Diltiazem
- Diphtheria Toxoid, Tetanus Toxoid, Acellular Pertussis Vaccine, DTaP; Haemophilus influenzae type b Conjugate Vaccine; Inactivated Poliovirus Vaccine, IPV
- Diphtheria Toxoid, Tetanus Toxoid, Acellular Pertussis Vaccine, DTaP; Hepatitis B Vaccine, Recombinant; Inactivated Poliovirus Vaccine, IPV
- Diphtheria Toxoid, Tetanus Toxoid, Acellular Pertussis Vaccine, DTaP; Inactivated Poliovirus Vaccine, IPV
- Diphtheria Toxoid; Tetanus Toxoid Adsorbed, DT, Td
- Diphtheria/Tetanus Toxoids; Pertussis Vaccine
- Diphtheria/Tetanus Toxoids; Pertussis Vaccine; Haemophilus influenzae type b Conjugate Vaccine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxepin
- Dronedarone
- Droperidol
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Enzalutamide
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Eslicarbazepine
- Esmolol
- Etravirine
- Ezogabine
- Fedratinib
- Fingolimod
- Flecainide
- Fluconazole
- Fluorouracil, 5-FU
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Haemophilus influenzae type b Conjugate Vaccine
- Haemophilus influenzae type b Conjugate Vaccine; Hepatitis B Vaccine, Recombinant
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Hepatitis A Vaccine, Inactivated
- Hepatitis A Vaccine, Inactivated; Hepatitis B Vaccine, Recombinant
- Hepatitis B Vaccine, Recombinant
- Histrelin
- Human Papillomavirus 9-Valent Vaccine
- Human Papillomavirus Bivalent Vaccine
- Human Papillomavirus Quadrivalent Vaccine
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocortisone
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Influenza Virus Vaccine
- Inotuzumab Ozogamicin
- Intranasal Influenza Vaccine
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivabradine
- Ivosidenib
- Japanese Encephalitis Virus Vaccine
- Ketoconazole
- Labetalol
- Lapatinib
- Lefamulin
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levofloxacin
- Lithium
- Live Vaccines
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lyme Disease Vaccine
- Macimorelin
- Maprotiline
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Mefloquine
- Meningococcal Conjugate Vaccine (MCV4)
- Meningococcal Group B Vaccine (3 strain)
- Meningococcal Group B Vaccine (4 strain)
- Meningococcal Haemophilus influenzae type b Conjugate Vaccine
- Meningococcal Polysaccharide Vaccine (MPSV4)
- Meperidine; Promethazine
- Metaproterenol
- Methadone
- Methylprednisolone
- Metoprolol
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitotane
- Modafinil
- Moxifloxacin
- Nadolol
- Nafcillin
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Non-Live Vaccines
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penbutolol
- Pentamidine
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pindolol
- Pirbuterol
- Pitolisant
- Pneumococcal Vaccine, Polyvalent
- Poliovirus Vaccine, Inactivated, IPV
- Posaconazole
- Prednisolone
- Prednisone
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propranolol
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Rabies Vaccine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Risperidone
- Ritonavir
- Romidepsin
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Salmeterol
- Saquinavir
- Secobarbital
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Solifenacin
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Tetanus Toxoid
- Tetrabenazine
- Thioridazine
- Timolol
- Tiotropium; Olodaterol
- Tipranavir
- Tolterodine
- Toremifene
- Trandolapril; Verapamil
- Trazodone
- Triamcinolone
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Tucatinib
- Typhoid Vaccine
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Varicella-Zoster Virus Vaccine, Live
- Vemurafenib
- Venlafaxine
- Verapamil
- Voriconazole
- Vorinostat
- Yellow Fever Vaccine, Live
- Ziprasidone