What is Segesterone Acetate and Ethinyl Estradiol
Segesterone acetate and ethinyl estradiol and used together in a combination hormonal contraceptive vaginal system (ring). Ethinyl estradiol is a potent, synthetic estrogen.
Segesterone, also known as 17alpha-hydroxy-16-methylene-19-norprogesterone or as 17alpha-deacetylnestorone, is a synthetic progestin. Segesterone has high progestational activity with negligible androgenic, glucocorticoid, or estrogenic activity in vivo.
The segesterone acetate; ethinyl estradiol vaginal ring is inserted for 3 weeks and then removed for a 1-week dose-free interval.
Brand Name
Annovera
Indications
- contraception
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- amenorrhea
- anaphylactoid reactions
- angioedema
- appetite stimulation
- bowel ischemia
- breakthrough bleeding
- candidiasis
- cataracts
- cervical dysplasia
- chills
- cholecystitis
- cholelithiasis
- cholestasis
- colitis
- cystitis
- depression
- diarrhea
- diplopia
- dysmenorrhea
- dyspepsia
- elevated hepatic enzymes
- emotional lability
- erythema multiforme
- erythema nodosum
- fever
- fluid retention
- galactorrhea
- headache
- hepatitis
- hepatoma
- hirsutism
- hyperglycemia
- hyperlipidemia
- hypertension
- infection
- infertility
- jaundice
- lactation suppression
- leukorrhea
- maculopapular rash
- mastalgia
- melasma
- menorrhagia
- menstrual irregularity
- migraine
- myocardial infarction
- nausea
- new primary malignancy
- oligomenorrhea
- optic neuritis
- pancreatitis
- papilledema
- peliosis hepatis
- photosensitivity
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- spontaneous fetal abortion
- stroke
- thromboembolism
- thrombosis
- toxic-shock syndrome
- urticaria
- vaginal bleeding
- vaginal discharge
- vaginal irritation
- vaginal pain
- vaginitis
- visual impairment
- vomiting
- weight gain
Monitoring Parameters
- pap smear
- pelvic exam
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- atrial fibrillation
- breast cancer
- breast-feeding
- cerebrovascular disease
- cervical cancer
- children
- chloasma
- cholestasis
- contact lenses
- contraceptive devices
- coronary artery disease
- coronary thrombosis
- depression
- diabetes mellitus
- endocarditis
- endometrial cancer
- gallbladder disease
- geriatric
- headache
- hepatic disease
- hepatitis
- hepatitis C infection
- hepatocellular cancer
- hereditary angioedema
- history of angioedema
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperlipidemia
- hypertriglyceridemia
- hypothyroidism
- infection
- jaundice
- laboratory test interference
- menstrual irregularity
- migraine
- myocardial infarction
- obesity
- obstetric delivery
- ovarian cancer
- porphyria
- pregnancy
- protein C deficiency
- protein S deficiency
- renal disease
- sexually transmitted disease
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thromboembolism
- thrombophlebitis
- tobacco smoking
- uterine cancer
- vaginal bleeding
- vaginal cancer
- valvular heart disease
- visual disturbance
Interactions
- Acarbose
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Acitretin
- Albiglutide
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amikacin
- Aminoglycosides
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Amprenavir
- Anastrozole
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Artemether; Lumefantrine
- Ascorbic Acid, Vitamin C
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Azithromycin
- Aztreonam
- Bacitracin
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendamustine
- Benzhydrocodone; Acetaminophen
- Betamethasone
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
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- Calcium
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- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
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- Colesevelam
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- Deflazacort
- Delafloxacin
- Delavirdine
- Demeclocycline
- Dexamethasone
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- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
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- Doripenem
- Doxazosin
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- Doxorubicin
- Doxycycline
- Dronabinol
- Dronedarone
- Dulaglutide
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
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- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Enasidenib
- Encorafenib
- Enzalutamide
- Eravacycline
- Ertapenem
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Estazolam
- Exemestane
- Exenatide
- Felbamate
- Felodipine
- Fidaxomicin
- Flibanserin
- Fluconazole
- Fludrocortisone
- Flunisolide
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosamprenavir
- Frovatriptan
- Gemifloxacin
- Gentamicin
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycylcyclines
- grapefruit juice
- Green Tea
- Griseofulvin
- Hemin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocortisone
- Icosapent ethyl
- Idelalisib
- Imatinib
- Imipenem; Cilastatin
- Imipenem; Cilastatin; Relebactam
- Incretin Mimetics
- Indinavir
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- Insulin Glargine; Lixisenatide
- Insulins
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isotretinoin
- Isradipine
- Itraconazole
- Ivosidenib
- Ixabepilone
- Kanamycin
- Ketoconazole
- Lamotrigine
- Lefamulin
- Leflunomide
- Lenalidomide
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Letrozole
- Levofloxacin
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin
- Linagliptin; Metformin
- Lincomycin
- Lincosamides
- Linezolid
- Liothyronine
- Liraglutide
- Lixisenatide
- Lomitapide
- Loperamide
- Loperamide; Simethicone
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- Lorazepam
- Lorlatinib
- Lumacaftor; Ivacaftor
- Mecamylamine
- Meglitinides
- Melatonin
- Mephobarbital
- Meropenem
- Meropenem; Vaborbactam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methohexital
- Methylprednisolone
- Metreleptin
- Metronidazole
- Metyrapone
- Miconazole
- Miconazole; Petrolatum; Zinc Oxide
- Midazolam
- Mifepristone
- Miglitol
- Miltefosine
- Mineral Oil
- Minocycline
- Minoxidil
- Mitotane
- Mivacurium
- Modafinil
- Mometasone
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Mycophenolate
- Nafcillin
- Naratriptan
- Nefazodone
- Nelfinavir
- Neomycin
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Nitrofurantoin
- Nitroprusside
- Norfloxacin
- Octreotide
- Ofloxacin
- Omadacycline
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Ospemifene
- Oxacillin
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- Paromomycin
- Pazopanib
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- St. John’s Wort, Hypericum perforatum
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- Sulfasalazine
- Sulfisoxazole
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- Tacrine
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- Tedizolid
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- Temazepam
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- Tetracycline
- Thalidomide
- Theophylline, Aminophylline
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- Thiopental
- Thyroid hormones
- Ticarcillin
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- Tigecycline
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- tobacco
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- Triazolam
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- Vancomycin
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