Segesterone Acetate and Ethinyl Estradiol

What is Segesterone Acetate and Ethinyl Estradiol

Segesterone acetate and ethinyl estradiol and used together in a combination hormonal contraceptive vaginal system (ring). Ethinyl estradiol is a potent, synthetic estrogen.

Segesterone, also known as 17alpha-hydroxy-16-methylene-19-norprogesterone or as 17alpha-deacetylnestorone, is a synthetic progestin. Segesterone has high progestational activity with negligible androgenic, glucocorticoid, or estrogenic activity in vivo.

The segesterone acetate; ethinyl estradiol vaginal ring is inserted for 3 weeks and then removed for a 1-week dose-free interval.

Brand Name

Annovera

Indications

  • contraception

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. alopecia
  4. amenorrhea
  5. anaphylactoid reactions
  6. angioedema
  7. appetite stimulation
  8. bowel ischemia
  9. breakthrough bleeding
  10. candidiasis
  11. cataracts
  12. cervical dysplasia
  13. chills
  14. cholecystitis
  15. cholelithiasis
  16. cholestasis
  17. colitis
  18. cystitis
  19. depression
  20. diarrhea
  21. diplopia
  22. dysmenorrhea
  23. dyspepsia
  24. elevated hepatic enzymes
  25. emotional lability
  26. erythema multiforme
  27. erythema nodosum
  28. fever
  29. fluid retention
  30. galactorrhea
  31. headache
  32. hepatitis
  33. hepatoma
  34. hirsutism
  35. hyperglycemia
  36. hyperlipidemia
  37. hypertension
  38. infection
  39. infertility
  40. jaundice
  41. lactation suppression
  42. leukorrhea
  43. maculopapular rash
  44. mastalgia
  45. melasma
  46. menorrhagia
  47. menstrual irregularity
  48. migraine
  49. myocardial infarction
  50. nausea
  51. new primary malignancy
  52. oligomenorrhea
  53. optic neuritis
  54. pancreatitis
  55. papilledema
  56. peliosis hepatis
  57. photosensitivity
  58. pruritus
  59. pulmonary embolism
  60. rash
  61. retinal thrombosis
  62. spontaneous fetal abortion
  63. stroke
  64. thromboembolism
  65. thrombosis
  66. toxic-shock syndrome
  67. urticaria
  68. vaginal bleeding
  69. vaginal discharge
  70. vaginal irritation
  71. vaginal pain
  72. vaginitis
  73. visual impairment
  74. vomiting
  75. weight gain

Monitoring Parameters

  • pap smear
  • pelvic exam

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • atrial fibrillation
  • breast cancer
  • breast-feeding
  • cerebrovascular disease
  • cervical cancer
  • children
  • chloasma
  • cholestasis
  • contact lenses
  • contraceptive devices
  • coronary artery disease
  • coronary thrombosis
  • depression
  • diabetes mellitus
  • endocarditis
  • endometrial cancer
  • gallbladder disease
  • geriatric
  • headache
  • hepatic disease
  • hepatitis
  • hepatitis C infection
  • hepatocellular cancer
  • hereditary angioedema
  • history of angioedema
  • human immunodeficiency virus (HIV) infection
  • hypercholesterolemia
  • hyperlipidemia
  • hypertriglyceridemia
  • hypothyroidism
  • infection
  • jaundice
  • laboratory test interference
  • menstrual irregularity
  • migraine
  • myocardial infarction
  • obesity
  • obstetric delivery
  • ovarian cancer
  • porphyria
  • pregnancy
  • protein C deficiency
  • protein S deficiency
  • renal disease
  • sexually transmitted disease
  • stroke
  • surgery
  • systemic lupus erythematosus (SLE)
  • thromboembolic disease
  • thromboembolism
  • thrombophlebitis
  • tobacco smoking
  • uterine cancer
  • vaginal bleeding
  • vaginal cancer
  • valvular heart disease
  • visual disturbance

Interactions

  • Acarbose
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetohexamide
  • Acitretin
  • Albiglutide
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amikacin
  • Aminoglycosides
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxicillin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amoxicillin; Clavulanic Acid
  • Ampicillin
  • Ampicillin; Sulbactam
  • Amprenavir
  • Anastrozole
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Artemether; Lumefantrine
  • Ascorbic Acid, Vitamin C
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atazanavir
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  • food
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  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycylcyclines
  • grapefruit juice
  • Green Tea
  • Griseofulvin
  • Hemin
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
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  • Linagliptin
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  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
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  • Prazosin
  • Prednisolone
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  • Primidone
  • Propafenone
  • Propoxyphene
  • Pyrimethamine; Sulfadoxine
  • Quazepam
  • Quinine
  • Raloxifene
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