Sebelipase alfa

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What is Sebelipase alfa

Sebelipase alfa is an intravenous therapy that provides a recombinant form of human lysosomal acid lipase (rhLAL) protein in patients with lysosomal acid lipase (LAL) deficiency.

LAL deficiency, also known as Wolman disease and cholesteryl ester storage disease (CESD), is an autosomal recessive lysosomal storage disorder that results in a marked decrease or loss in activity of the lysosomal acid lipase (LAL) enzyme. 

Brand Name

Kanuma

Indications & Dosage

  • lysosomal acid lipase (LAL) deficiency

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactic shock
  4. anemia
  5. antibody formation
  6. anxiety
  7. asthenia
  8. chest pain (unspecified)
  9. chills
  10. constipation
  11. cough
  12. diarrhea
  13. dyspnea
  14. edema
  15. fever
  16. headache
  17. hyperemia
  18. hyperlipidemia
  19. hypertension
  20. hypotonia
  21. irritability
  22. nausea
  23. pallor
  24. pharyngitis
  25. pruritus
  26. rash
  27. rhinitis
  28. rhinorrhea
  29. sneezing
  30. tachypnea
  31. urticaria
  32. vomiting

Monitoring Parameters

  • growth rate
  • serum lipid profile

Contraindications

  • breast-feeding
  • egg hypersensitivity
  • pregnancy
  • requires a specialized care setting

Interactions

There are no drug interactions associated with Sebelipase alfa products.

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